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免疫類疾?。庖呶蓙y)

免疫系統(tǒng)是人體抵御外來病原體、維持內(nèi)部穩(wěn)定的重要系統(tǒng)。免疫紊亂是指人體免疫系統(tǒng)功能失調(diào)的狀態(tài),這種失調(diào)可能是由于遺傳、環(huán)境、生活方式等多種因素引起的,可能會(huì)導(dǎo)致多種疾病。免疫紊亂可以分為兩大類:免疫缺陷和自身免疫疾病。

  • 免疫缺陷:是指免疫系統(tǒng)功能低下,無法有效抵御外來病原體的侵害。免疫缺陷可能是先天性的,如先天性免疫缺陷?。灰部赡苁呛筇煨缘?,如艾滋病、長(zhǎng)期使用免疫抑制劑等。免疫缺陷會(huì)導(dǎo)致患者容易感染、疾病恢復(fù)緩慢等問題。
  • 自身免疫疾?。?/b>是指免疫系統(tǒng)錯(cuò)誤地攻擊自身組織,導(dǎo)致組織損傷和功能障礙。常見的自身免疫疾病包括類風(fēng)濕關(guān)節(jié)炎、系統(tǒng)性紅斑狼瘡、甲狀腺疾病等。

免疫缺陷和自身免疫疾病是兩類重要的免疫相關(guān)疾病,近年來在藥物研發(fā)方面取得了顯著進(jìn)展:

  • 針對(duì)免疫缺陷的藥物研發(fā):leniolisib是一種口服選擇性磷脂酰肌醇3-激酶δ(PI3Kδ)抑制劑,已被美國(guó)食品和藥物管理局(FDA)受理進(jìn)行優(yōu)先審查,用于治療活化的肌醇磷脂3-激酶δ綜合征(APDS),這是一種罕見的原發(fā)性免疫缺陷病。這表明針對(duì)特定免疫缺陷病的精準(zhǔn)治療策略正在逐步實(shí)現(xiàn)。
  • 針對(duì)自身免疫疾病的藥物研發(fā):自身免疫性疾病的治療藥物包括傳統(tǒng)的合成抗風(fēng)濕藥(DMARDs),如激素、免疫抑制劑、免疫調(diào)節(jié)劑和抗炎藥物。近年來,生物制劑和靶向DMARDs的研發(fā)取得了顯著進(jìn)展,例如大分子單克隆抗體(如英夫利昔單抗、托珠單抗)和JAK抑制劑(如托法替尼、巴瑞特尼)。

此外,細(xì)胞因子類藥物通過調(diào)節(jié)免疫反應(yīng)在治療免疫缺陷和自身免疫疾病中具有重要作用。例如,通過PEG化增加IL-2半衰期的藥物NKTR-214,以及通過融合技術(shù)增加細(xì)胞因子靶向特異性的藥物,如ALT-803(IL-15“超級(jí)激動(dòng)劑”復(fù)合物)??贵w融合細(xì)胞因子,如IL-2、TNF、IL-15等,通過特定的抗體導(dǎo)向技術(shù),將細(xì)胞因子定向輸送到疾病部位,以提高治療效果和減少副作用。

免疫類疾病藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

MS4A1 (CD20)
CSB-MP015007HU
CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL

TNFRSF17 (BCMA)
CSB-MP023974HU1
CSB-MP023974HU1 Activity Verified

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP004900HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP004940HU Activity Verified

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CSB-MP011661HU2-B Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL4 (CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R,the EC50 is 12.68-14.23 ng/mL.

CSB-MP023983HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L (CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 來源 蛋白標(biāo)簽
Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active) CSB-MP773799HU BTLA Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active) CSB-MP773799HU1 BTLA Mammalian cell C-terminal 10xHis-tagged
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active) CSB-AP005061HU CD19 Mammalian cell C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active) CSB-MP004900HU CD22 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active) CSB-MP004925HU CD33 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-AP005191HU CD40LG E.coli Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-MP004937HU3 CD40LG Mammalian cell N-terminal hFc-Flag-tagged
Recombinant Human CD44 antigen (CD44), partial (Active) CSB-MP004938HU(F1) CD44 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD44 antigen (CD44), partial, Biotinylated (Active) CSB-MP004938HU(F1)j1-B CD44 Mammalian cell C-terminal mFc-Avi-tagged
Recombinant Macaca fascicularis CD44 antigen (CD44), partial (Active) CSB-MP4290MOV CD44 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human T-cell antigen CD7 (CD7), partial (Active) CSB-MP004953HU CD7 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active) CSB-MP004954HU1 CD70 Mammalian cell N-terminal 10xHis-tagged
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active) CSB-AP005161HU CD86 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active) CSB-AP003581HU CSF2 E.coli Tag-Free

● 穩(wěn)定細(xì)胞株

CSB-SC020067HU FACS

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

C3 Recombinant Monoclonal Antibody
CSB-RA303909A0HU
CSB-RA303909A0HU FC

Overlay histogram showing HepG2 cells stained with CSB-RA303909A0HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

FN1 Recombinant Monoclonal Antibody
CSB-RA919940A0HU
CSB-RA919940A0HU FC

Overlay Peak curve showing 3T3 cells stained with CSB-RA919940A0HU (red line) at 1:50.

MET Recombinant Monoclonal Antibody
CSB-RA983271A0HU
CSB-RA983271A0HU FC

Overlay histogram showing Hela cells stained with CSB-RA983271A0HU (red line) at 1:50.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
ALB Recombinant Monoclonal Antibody CSB-RA264109A0HU ALB Human ELISA, FC
APP Recombinant Monoclonal Antibody CSB-RA994273A0HU APP Human, Mouse, Rat ELISA, WB, IF
BTLA Recombinant Monoclonal Antibody CSB-RA773799MA1HU BTLA Human ELISA, FC
C3 Recombinant Monoclonal Antibody CSB-RA303909A0HU C3 Human ELISA, WB, IHC, FC
C3 Recombinant Monoclonal Antibody CSB-RA699863A0HU C3 Human ELISA, IHC
C5 Recombinant Monoclonal Antibody CSB-RA003995MA1HU C5 Human ELISA, FC
CD19 Recombinant Monoclonal Antibody CSB-RA004888A0HU CD19 Human ELISA
CD19 Recombinant Monoclonal Antibody CSB-RA780821A0HU CD19 Human ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody CSB-RA004888MA1HU CD19 Human, Mouse ELISA, WB
CD22 Recombinant Monoclonal Antibody CSB-RA962691A0HU CD22 Human ELISA, IHC
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD34 Recombinant Monoclonal Antibody CSB-RA004926A0HU CD34 Human ELISA, IHC
CD38 Recombinant Monoclonal Antibody CSB-RA796695A0HU CD38 Human ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody CSB-RA004931MA1HU CD3E Human ELISA, FC
CD4 Recombinant Monoclonal Antibody CSB-RA004935A0HU CD4 Human ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD44 Recombinant Monoclonal Antibody CSB-RA004938A0HU CD44 Human ELISA, WB, IHC
CD44 Recombinant Monoclonal Antibody CSB-RA292372A0HU CD44 Human ELISA, WB, IHC, IF, FC

● ELISA試劑盒

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 檢測(cè)范圍 靈敏度
Bovine Albumin(Alb) ELISA kit CSB-E08664b ALB 0.313 μg/mL-80 μg/mL 0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit CSB-E13878m ALB 0.781 μg/mL-200 μg/mL 0.110 μg/mL
Dog Albumin(Alb) ELISA Kit CSB-E15757c ALB 0.273 μg/mL-35 μg/mL 0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit CSB-E15839Sh ALB 350 μg/mL-21.88 μg/mL 5.5 μg/mL
Horse Albumin(Alb) ELISA Kit CSB-E16205Hs ALB 1.25 μg/mL-80 μg/mL 1.247 μg/mL
Pig Albumin (Alb) ELISA Kit CSB-E16207p ALB 0.03 μg/mL-7000 μg/mL 0.03 μg/mL
Goat Albumin (Alb)ELISA Kit CSB-E15758G ALB 0.17 μg/mL-350 μg/mL 0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit CSB-E15765Gp ALB 0.156 μg/mL-10 μg/mL 0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit CSB-E16204Rb ALB 0.273 μg/mL-70 μg/mL 0.117 μg/mL
Rat Amyloid beta A4 protein(APP) ELISA kit CSB-EL001950RA APP 15.6 ng/mL-1000 ng/mL 3.9 ng/mL
Human B- and T-lymphocyte attenuator(BTLA) ELISA kit CSB-EL002868HU BTLA 0.45 ng/mL-30 ng/mL 0.11 ng/mL
Mouse B- and T-lymphocyte attenuator(BTLA) ELISA kit CSB-EL002868MO BTLA 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human Complement C1s subcomponent(C1S) ELISA kit CSB-EL003657HU C1S 25 ng/mL-1600 ng/mL 6.25 ng/mL
Human Complement 3,C3 ELISA Kit CSB-E08665h C3 4.7 ng/mL-300 ng/mL 4.031 ng/mL
Pig Complement 3,C3 ELISA Kit CSB-E06920p C3 0.625 μg/mL-10 μg/mL 0.625 μg/mL
Rat Complement 3,C3 ELISA Kit CSB-E08666r C3 0.625 μg/mL-40 μg/mL 0.156 μg/mL
Mouse Complement 3,C3 ELISA Kit CSB-E08667m C3 93.75 ng/mL-6000 ng/mL 23.44 ng/mL
Rabbit Complement 3,C3 ELISA Kit CSB-E08668Rb C3 27.3 ng/mL-7000 ng/mL 27.3 ng/mL
Fish Complement 3,C3 ELISA Kit CSB-E09727s C3 12.5 μg/mL-500 μg/mL 12.5 μg/mL
Monkey Complement 3(C3)ELISA Kit CSB-E16528Mk C3 4.68 ng/mL-300 ng/mL 1.17 ng/mL