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CCR5

CCR5(趨化因子受體5)是一種G蛋白偶聯(lián)受體,由352個(gè)氨基酸殘基組成,分子量約為40.6kDa。其結(jié)構(gòu)包括胞外N末端、三個(gè)胞外環(huán)(EL1、EL2、EL3)、三個(gè)胞內(nèi)環(huán)(IL1、IL2、IL3)、7個(gè)跨膜α螺旋和胞內(nèi)C末端。CCR5主要在免疫細(xì)胞上表達(dá),如記憶性的靜止期T淋巴細(xì)胞、單核細(xì)胞、未成熟的樹(shù)突狀細(xì)胞等,調(diào)控這些細(xì)胞的遷移、增殖與免疫反應(yīng)。CCR5的功能涉及免疫細(xì)胞遷移調(diào)控、免疫應(yīng)答以及作為HIV-1早期侵染的輔助受體,參與病毒與宿主細(xì)胞的結(jié)合和膜融合過(guò)程。 CCR5參與的信號(hào)通路主要包括趨化因子信號(hào)通路,與趨化因子結(jié)合后激活G蛋白信號(hào)轉(zhuǎn)導(dǎo),進(jìn)而激活下游的細(xì)胞內(nèi)信號(hào)級(jí)聯(lián),促進(jìn)免疫細(xì)胞的活化和增殖。此外,CCR5的N末端和第二胞外區(qū)與HIV-1的gp120糖蛋白相互作用,協(xié)助病毒進(jìn)入宿主細(xì)胞。某些CCR5的突變體,例如CCR5Δ32,能夠抵抗HIV的感染并延緩病情惡化。這些發(fā)現(xiàn)表明CCR5在免疫應(yīng)答和HIV-1感染中發(fā)揮著重要作用,是研究和治療相關(guān)疾病的潛在靶點(diǎn)。

熱銷(xiāo)產(chǎn)品

Recombinant Human C-C chemokine receptor type 5 (CCR5)-VLPs (Active) (CSB-MP004844HU)

驗(yàn)證數(shù)據(jù)

CSB-MP004844HU

CSB-MP004844HU is detected by Mouse anti-6*His monoclonal antibody.(This tag can be tested only under denaturing conditions.)

CSB-MP004844HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CCR5 at 10 μg/ml can bind Anti-CCR5 recombinant antibody (CSB-RA004844MA1HU). The EC50 is 1.099-1.287 ng/mL.The VLPs (CSB-MP3838) is negative control.

CCR5 Antibodies

CCR5 for Homo sapiens (Human)

CCR5 for Mus musculus (Mouse)

CCR5 Proteins

CCR5 Proteins for Mus musculus (Mouse)

CCR5 Proteins for Macaca mulatta (Rhesus macaque)

CCR5 Proteins for Papio anubis (Olive baboon)

CCR5 Proteins for Papio hamadryas (Hamadryas baboon)

CCR5 Proteins for Homo sapiens (Human)

CCR5 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

CCR5 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

CCR5 Proteins for Pan troglodytes (Chimpanzee)

CCR5 Proteins for Semnopithecus entellus (Hanuman langur) (Presbytis entellus)

CCR5 Proteins for Macaca nemestrina (Pig-tailed macaque)

CCR5 Proteins for Pongo abelii (Sumatran orangutan)

CCR5 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

CCR5 Proteins for Lophocebus aterrimus (Black crested mangabey) (Cercocebus aterrimus)

CCR5 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

CCR5 Proteins for Rattus norvegicus (Rat)

CCR5 Proteins for Trachypithecus francoisi (Francois's leaf monkey) (Presbytis francoisi)

CCR5 Proteins for Pygathrix nemaeus (Dove langur) (Douc langur)

CCR5 Proteins for Trachypithecus phayrei (Phayre's leaf monkey)

CCR5 Proteins for Pongo pygmaeus (Bornean orangutan)

CCR5 Proteins for Macaca arctoides (Stump-tailed macaque)

CCR5 Proteins for Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)

CCR5 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

CCR5 Proteins for Pygathrix bieti (Black snub-nosed monkey) (Rhinopithecus bieti)

CCR5 Proteins for Rhinopithecus avunculus (Tonkin snub-nosed monkey) (Pygathrix avunculus)

CCR5 Proteins for Oryctolagus cuniculus (Rabbit)

CCR5 Proteins for Bos taurus (Bovine)

CCR5 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CCR5 Proteins for Callithrix humeralifera (Tassel-eared marmoset)

CCR5 Proteins for Saimiri sciureus (Common squirrel monkey)

CCR5 Proteins for Hylobates syndactylus (Siamang) (Symphalangus syndactylus)

CCR5 Proteins for Theropithecus gelada (Gelada baboon)

CCR5 Proteins for Alouatta seniculus (Red howler monkey)

CCR5 Proteins for Ateles geoffroyi (Black-handed spider monkey)

CCR5 Proteins for Mandrillus sphinx (Mandrill) (Papio sphinx)

CCR5 Proteins for Hylobates moloch (Silvery gibbon)

CCR5 Proteins for Colobus polykomos (Western black-and-white colobus monkey)

CCR5 Proteins for Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin)

CCR5 Proteins for Mandrillus leucophaeus (Drill) (Papio leucophaeus)

CCR5 Proteins for Trachypithecus johnii (Nilgiri langur) (Semnopithecus johnii)

CCR5 Proteins for Nasalis larvatus (Proboscis monkey)

CCR5 Proteins for Callicebus moloch (Dusky titi monkey)

CCR5 Proteins for Erythrocebus patas (Red guenon) (Cercopithecus patas)

CCR5 Proteins for Cercopithecus tantalus (Tantalus monkey) (Chlorocebus tantalus)

CCR5 Proteins for Cercopithecus solatus (Sun-tailed monkey)

CCR5 Proteins for Cercopithecus ascanius (Black-cheeked white-nosed monkey) (Redtail monkey)

CCR5 Proteins for Cercocebus galeritus (Tana river mangabey)

CCR5 Proteins for Cercopithecus cephus (Moustached monkey)

CCR5 Proteins for Cercopithecus nictitans (Greater white-nosed monkey) (White-nosed guenon)

CCR5 Proteins for Cercopithecus pygerythrus (Vervet monkey)

CCR5 Proteins for Cercopithecus sabaeus (Green monkey) (Chlorocebus sabaeus)

CCR5 Proteins for Cercopithecus lhoesti (L'Hoest's monkey)