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腎癌

腎癌,也稱為腎細(xì)胞癌,是一種起源于腎小管上皮細(xì)胞的惡性腫瘤,可發(fā)生在腎臟的任何部位。腎癌的臨床表現(xiàn)多變,容易誤診為其他疾病。常見的癥狀包括血尿、腰痛、腫塊以及全身表現(xiàn)如發(fā)熱、高血壓等。

腎癌傳統(tǒng)的治療方式包括手術(shù)切除、放射療法和免疫療法。近年來,靶向治療和免疫療法的發(fā)展為腎癌患者提供了新的治療選擇。靶向治療藥物專門針對癌細(xì)胞中的特定異常,通過阻斷這些異常來殺死癌細(xì)胞。例如,VEGFR酪氨酸激酶抑制劑類藥物是治療腎癌的常見靶向藥物。免疫療法則利用患者自身的免疫系統(tǒng)來對抗癌癥,通過干預(yù)癌細(xì)胞躲避免疫系統(tǒng)的機(jī)制來發(fā)揮作用。PD-1抑制劑和CTLA-4抑制劑是兩種常用的免疫檢查點抑制劑,它們通過激活T細(xì)胞來攻擊癌細(xì)胞。

腎癌藥物靶點相關(guān)產(chǎn)品推薦

● 靶點蛋白

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP006163HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP011649HU3 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP004954HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human CD70 at 2 μg/ml can bind Anti-CD70 antibody, the EC50 is 2.414-3.196 ng/mL.

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP733578HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC50 of human CD276 protein is 1.961-2.243 ng/ml.

產(chǎn)品名稱 貨號 靶點 來源 蛋白標(biāo)簽
Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial (Active) CSB-MP011649HU3 IL2RA Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Interleukin-2 (IL2) (Active) CSB-MP011629HU IL2 Mammalian cell N-terminal hFc-tagged
Recombinant Mouse Interleukin-2 (Il2) (Active) CSB-AP004821MO Il2 E.coli Tag-Free
Recombinant Human Interleukin-2 (IL2), partial (Active) CSB-AP004711HU IL2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Interleukin-2 (IL2) (Active) CSB-AP004501HU IL2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Interleukin-2 (IL2) (Active) CSB-AP004381HU IL2 E.coli Tag-Free
Recombinant Human Interleukin-2 protein (IL2) (Active) CSB-AP001691HU IL2 E.Coli Tag-Free
Recombinant Mouse Interleukin-15 receptor subunit alpha (Il15ra), partial (Active) CSB-AP004801MO Il15ra Mammalian cell C-terminal Fc-tagged
Recombinant Human Interleukin-15 receptor subunit alpha (IL15RA), partial (Active) CSB-AP004551HU IL15RA Mammalian cell C-terminal Fc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Macaca fascicularis Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3), partial (Active) CSB-MP4278MOV ENPP3 Mammalian cell N-terminal 10xHis-tagged
Recombinant Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3), partial (Active) CSB-MP007681HU ENPP3 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human CD70 antigen (CD70), partial (Active) CSB-MP004954HU1 CD70 Mammalian cell N-terminal 10xHis-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged

● 穩(wěn)定細(xì)胞株

CSB-SC007681HU FACS

HEK293T/Human ENPP3 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human ENPP3 HEK293T Stable cells (red line) were stained with anti-ENPP3 antibody (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

BTLA Recombinant Monoclonal Antibody
CSB-RA773799MA1HU
CSB-RA773799MA1HU FC

Untransfected HEK293T cells (green line) and transfected Human ENPP3 HEK293T Stable cells (red line) were stained with anti-ENPP3 antibody (2μg/1*106 cells).

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU
CSB-RA244537A0HU FC

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU
CSB-RA004936MA1HU FC

Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.

產(chǎn)品名稱 貨號 靶點 反應(yīng)種屬 應(yīng)用范圍
ANGPT2 Recombinant Monoclonal Antibody CSB-RA191985A0HU ANGPT2 Human ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody CSB-RA001707MA01HU ANGPT2 Human ELISA
BTLA Recombinant Monoclonal Antibody CSB-RA773799MA1HU BTLA Human ELISA, FC
CA9 Recombinant Monoclonal Antibody CSB-RA614990A0HU CA9 Human ELISA, IHC
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD27 Recombinant Monoclonal Antibody CSB-RA953976A0HU CD27 Human ELISA, WB
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD70 Recombinant Monoclonal Antibody CSB-RA004954MA1HU CD70 Human ELISA
CDH6 Recombinant Monoclonal Antibody CSB-RA005055MA1HU CDH6 Human ELISA
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
ENPP3 Recombinant Monoclonal Antibody CSB-RA007681MA1HU ENPP3 Human, Macaca fascicularis ELISA,FC
ERBB2 Recombinant Monoclonal Antibody CSB-RA260392A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU ERBB2 Human ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody CSB-RA588766A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA2HU ERBB2 Human ELISA, IHC
IFNAR1 Recombinant Monoclonal Antibody CSB-RA011046A0HU IFNAR1 Human ELISA
IL2RA Recombinant Monoclonal Antibody CSB-RA011649MA1HU IL2RA Human ELISA, IF
NT5E Recombinant Monoclonal Antibody CSB-RA978310A0HU NT5E Human ELISA, IHC
PDCD1 Recombinant Monoclonal Antibody CSB-RA240597A0HU PDCD1 Human ELISA, WB, IHC
TOP1 Recombinant Monoclonal Antibody CSB-RA792129A0HU TOP1 Human ELISA, WB, IHC, FC, IP
TPBG Recombinant Monoclonal Antibody CSB-RA669019A0HU TPBG Human ELISA, IHC
TPBG Recombinant Monoclonal Antibody CSB-RA902876A0HU TPBG Human, Mouse ELISA, WB, IHC
TPBG Recombinant Monoclonal Antibody CSB-RA024093MA1HU TPBG Human, Macaca mulatta ELISA

● ELISA試劑盒

產(chǎn)品名稱 貨號 靶點 檢測范圍 靈敏度
Human Angiopoietin 2,ANG-2 ELISA Kit CSB-E04500h ANGPT2 39 pg/mL-2500 pg/mL 9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit CSB-E07304r ANGPT2 Request Information Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit CSB-E07305m ANGPT2 0.156 pg/mL-10 pg/mL 0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit CSB-E08460p ANGPT2 0.94 ng/mL-60 ng/mL 0.235 ng/mL
Human B- and T-lymphocyte attenuator(BTLA) ELISA kit CSB-EL002868HU BTLA 0.45 ng/mL-30 ng/mL 0.11 ng/mL
Mouse B- and T-lymphocyte attenuator(BTLA) ELISA kit CSB-EL002868MO BTLA 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human Carbonic Anhydrase 9(CA9) ELISA Kit CSB-E13266h CA9 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit CSB-E14285h CD276 3.12 ng/mL-200 ng/mL 0.78 ng/mL
Human soluble cluster of differentiation 28,sCD28 ELISA Kit CSB-E09296h CD28 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human CD70 antigen(CD70) ELISA kit CSB-EL004954HU CD70 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Mouse CD70 antigen(CD70) ELISA kit CSB-EL004954MO CD70 Request Information Request Information
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL
Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 3(ENPP3) ELISA kit CSB-EL007681HU ENPP3 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit CSB-E11161h ERBB2 0.156 ng/mL-10 ng/mL 0.04 ng/mL