Your Good Partner in Biology Research

結直腸癌

結直腸癌是一種起源于結腸或直腸粘膜上皮細胞的惡性腫瘤,其發(fā)病率在全球范圍內居高不下,是導致癌癥相關死亡的主要原因之一。根據(jù)腫瘤的位置,結直腸癌可以分為結腸癌和直腸癌。結腸癌通常起源于結腸的息肉,而直腸癌則多發(fā)生在直腸的下段。結直腸癌的癥狀包括便血、排便習慣改變、腹痛、體重下降等。

結直腸癌的治療已經(jīng)從傳統(tǒng)的化療藥物發(fā)展到針對特定分子靶點的靶向治療和免疫治療。以下是一些重要的藥物靶點及其相關藥物的研發(fā)進展:

  • EGFR (表皮生長因子受體):在約10%的結直腸癌中過度表達,針對EGFR的單克隆抗體如西妥昔單抗已被用于治療某些類型的結直腸癌。
  • RAS (KRAS和NRAS):RAS基因突變在結直腸癌中較為常見,尤其是KRAS突變。近年來,針對KRAS G12C突變的抑制劑如索托拉西布(Sotorasib, AMG510)取得了突破性進展,為攜帶此突變的患者提供了新的治療選擇。
  • BRAF:BRAF V600E突變是結直腸癌中另一個重要的治療靶點。BRAF抑制劑如維莫非尼(Vemurafenib)和MEK抑制劑如考比替尼(Cobimetinib)的聯(lián)合使用,已經(jīng)在治療BRAF突變的晚期結直腸癌中顯示出較好的療效2。
  • HER2 (人表皮生長因子受體2):HER2過表達在一部分結直腸癌患者中出現(xiàn),針對HER2的靶向治療如圖卡替尼(Tucatinib)聯(lián)合曲妥珠單抗(Trastuzumab)已經(jīng)獲得FDA批準,用于治療HER2陽性的晚期結直腸癌患者。
  • MSI (微衛(wèi)星不穩(wěn)定性):MSI-H或dMMR (錯配修復缺陷)的結直腸癌對免疫治療有較好的反應。免疫檢查點抑制劑如帕博利珠單抗(Pembrolizumab)在這類患者中已經(jīng)顯示出顯著的療效。
  • VEGF (血管內皮生長因子):抗VEGF單抗如貝伐珠單抗(Bevacizumab)通過抑制腫瘤血管生成,已經(jīng)被廣泛應用于晚期結直腸癌的治療。

結直腸癌藥物靶點相關產(chǎn)品推薦

● 靶點蛋白

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP009705HU(M) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP005165HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM5 at 2μg/mL can bind Anti-CEACAM5 recombinant antibody (CSB-RA005165MA1HU), the EC50 is 0.8955-1.719 ng/mL.

CSB-MP011649HU3 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.

CSB-MP023997HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9(CSB-MP023984HU1), the EC50 is 2.671-3.702 ng/mL

產(chǎn)品名稱 貨號 靶點 來源 蛋白標簽
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active) CSB-MP733578HU CD276 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human CD44 antigen (CD44), partial (Active) CSB-MP004938HU(F1) CD44 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD44 antigen (CD44), partial, Biotinylated (Active) CSB-MP004938HU(F1)j1-B CD44 Mammalian cell C-terminal mFc-Avi-tagged
Recombinant Macaca fascicularis CD44 antigen (CD44), partial (Active) CSB-MP4290MOV CD44 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) CSB-MP005165HU CEACAM5 Mammalian cell C-terminal?10xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) CSB-MP007765HU ERBB3 Mammalian cell C-terminal hFc-tagged
Recombinant Human Hepatocyte growth factor (HGF) (Active) CSB-AP003681HU HGF Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Interleukin-15 receptor subunit alpha (IL15RA), partial (Active) CSB-AP004551HU IL15RA Mammalian cell C-terminal Fc-tagged
Recombinant Mouse Interleukin-15 receptor subunit alpha (Il15ra), partial (Active) CSB-AP004801MO Il15ra Mammalian cell C-terminal Fc-tagged
Recombinant Human Interleukin-2 protein (IL2) (Active) CSB-AP001691HU IL2 E.Coli Tag-Free

● 重組抗體

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CEACAM5 Recombinant Monoclonal Antibody
CSB-RA005165MA3HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA005165MA3HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

IGF1R Recombinant Monoclonal Antibody
CSB-RA011087MA1HU
CSB-RA011087MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.

產(chǎn)品名稱 貨號 靶點 反應種屬 應用范圍
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA3HU CEACAM5 Human ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA1HU CEACAM5 Human ELISA
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
EPCAM Recombinant Monoclonal Antibody CSB-RA932207A0HU EPCAM Human ELISA, WB
EPCAM Recombinant Monoclonal Antibody CSB-RA439934A0HU EPCAM Human ELISA, WB, IHC
EPCAM Recombinant Monoclonal Antibody CSB-RA007717MA1HU EPCAM Human ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody CSB-RA260392A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU ERBB2 Human ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody CSB-RA588766A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA2HU ERBB2 Human ELISA, IHC
ERBB3 Recombinant Monoclonal Antibody CSB-RA937008A0HU ERBB3 Human ELISA, IF
IGF1R Recombinant Monoclonal Antibody CSB-RA011087MA1HU IGF1R Human ELISA, FC
IL2RA Recombinant Monoclonal Antibody CSB-RA011649MA1HU IL2RA Human ELISA, IF
MET Recombinant Monoclonal Antibody CSB-RA983271A0HU MET Human ELISA, WB, IHC, IF, FC
MET Recombinant Monoclonal Antibody CSB-RA634199A0HU MET Human ELISA, IHC
MET Recombinant Monoclonal Antibody CSB-RA013714MA1HU MET Human ELISA, IF, FC
NT5E Recombinant Monoclonal Antibody CSB-RA978310A0HU NT5E Human ELISA, IHC
PDCD1 Recombinant Monoclonal Antibody CSB-RA240597A0HU PDCD1 Human ELISA, WB, IHC
TOP1 Recombinant Monoclonal Antibody CSB-RA792129A0HU TOP1 Human ELISA, WB, IHC, FC, IP

● ELISA試劑盒

產(chǎn)品名稱 貨號 靶點 檢測范圍 靈敏度
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit CSB-E14285h CD276 3.12 ng/mL-200 ng/mL 0.78 ng/mL
Human cluster Of differentiation,CD44 ELISA Kit CSB-E11846h CD44 78 pg/mL-5000 pg/mL 19.5 pg/mL
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human carcinoembryonic antigen,CEA ELISA Kit CSB-E04767h CEACAM5 5 ng/mL-120 ng/mL 2 ng/mL
Mouse carcinoembryonic antign,CEA ELISA Kit CSB-E13925m CEACAM5 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Human Delta-like protein 4(DLL4) ELISA kit CSB-EL006949HU DLL4 23.5 pg/mL-1500 pg/mL 5.8 pg/mL
Mouse Delta-like protein 4(DLL4) ELISA kit CSB-EL006949MO DLL4 10 ng/mL-0.16 ng/mL 0.04 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL
Human Epithelial cell adhesion molecule(EPCAM) ELISA kit CSB-EL007717HU EPCAM 0.625 ng/ml-40 ng/ml 0.156 ng/ml
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit CSB-E11161h ERBB2 0.156 ng/mL-10 ng/mL 0.04 ng/mL
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit CSB-EL007765HU ERBB3 125 pg/mL-8000 pg/mL 31.25 pg/mL
Human growth differentiation factor 15(GDF15)ELISA Kit CSB-E12009h GDF15 7.8 pg/mL-500 pg/mL 1.95 pg/mL
Rat growth differentiation factor 15(GDF15)ELISA Kit CSB-E16317r GDF15 1.56 pg/mL-100 pg/mL 0.39 pg/mL
Mouse Growth/differentiation factor 15(GDF15) ELISA kit CSB-EL009345MO GDF15 7.8 pg/ml -500 pg/ml 1.95 pg/ml