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宮頸癌

宮頸癌是一種發(fā)生在女性生殖系統(tǒng)中宮頸部位的惡性腫瘤。宮頸癌的主要病因是人乳頭狀瘤病毒(HPV)感染,尤其是HPV的高危型別,如HPV 16和18型。其他相關(guān)的危險(xiǎn)因素包括抽煙、多個(gè)性伴侶、性生活開始過(guò)早、多孕多產(chǎn)以及免疫功能缺陷等。宮頸癌的臨床表現(xiàn)隨著疾病的進(jìn)展而變化,早期可能沒有癥狀,但隨著病情發(fā)展,可能出現(xiàn)接觸性出血、異常陰道流血等癥狀。

在宮頸癌的治療方面,根據(jù)癌癥的分期和患者的具體情況,常用的治療手段包括手術(shù)、放療、化療、靶向治療和免疫治療。手術(shù)通常適用于早期宮頸癌,而放療和化療則常用于中晚期宮頸癌的治療。靶向治療和免疫治療是近年來(lái)新興的治療方法,主要用于復(fù)發(fā)或晚期宮頸癌的治療。

宮頸癌藥物研發(fā)的目前多集中在以下幾個(gè)方向:

  • 免疫檢查點(diǎn)抑制劑:PD1/L1抑制劑如帕博利珠單抗(PD-1抑制劑)已被美國(guó)FDA批準(zhǔn)用于化療期間或后疾病進(jìn)展的復(fù)發(fā)性或轉(zhuǎn)移性宮頸癌的治療。此外,帕博利珠單抗聯(lián)合化療也被批準(zhǔn)用于腫瘤表達(dá)PD-L1的持續(xù)性、復(fù)發(fā)性或轉(zhuǎn)移性宮頸癌患者的一線治療。
  • 抗體藥物偶聯(lián)物(ADCs):Tisotumab Vedotin(TV)是首個(gè)獲批治療宮頸癌的ADC藥物,用于在化療期間或化療后病情進(jìn)展的復(fù)發(fā)性或轉(zhuǎn)移性宮頸癌患者。TV的宮頸癌二線治療的Ⅲ期innovaTV301試驗(yàn)顯示,相比傳統(tǒng)化療,TV能顯著降低死亡風(fēng)險(xiǎn)并改善患者的總生存期(OS)。
  • 雙特異性抗體:國(guó)內(nèi)企業(yè)自主研發(fā)的靶向PD-1和CTLA-4的雙特異性抗體凱得寧單抗(Cadonilimab,AK104)已申請(qǐng)上市,用于復(fù)發(fā)或轉(zhuǎn)移性宮頸癌的治療,并獲得了優(yōu)先審評(píng)。

宮頸癌藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP006163HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

ERBB2 (HER2)
CSB-MP007763HU
CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP675446HU Activity Verified

HFACS assay shows that Human TIGIT can bind to 293F cell overexpressing human CD155.

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP007765HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized NRG1 (CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC50 is 12.32-15.74 ng/ml.

CSB-MP023412HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized TFRC (CSB-MP3648HU)at 2μg/mL can bind Human TF,the EC50 is 58.72-77.84 ng/mL.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 來(lái)源 蛋白標(biāo)簽
Recombinant Human C-C chemokine receptor type 8 (CCR8)-VLPs (Active) CSB-MP004847HU CCR8 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human B-cell receptor CD22 (CD22), partial (Active) CSB-MP004900HU CD22 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human CD226 antigen (CD226), partial (Active) CSB-MP618996HU CD226 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) CSB-MP005165HU CEACAM5 Mammalian cell C-terminal?10xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) (Active) CSB-MP005166HU CEACAM6 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active) CSB-AP003591HU CSF2RA Mammalian cell C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human papillomavirus type 16 Protein E7 (E7) (Active) CSB-EP365855HMLg5 E7 E.coli N-terminal 6xHis-tagged and C-terminal 6xHis-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) CSB-MP007765HU ERBB3 Mammalian cell C-terminal hFc-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active) CSB-AP005281HU HAVCR2 Mammalian cell C-terminal FC-Avi-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active) CSB-AP005291HU HAVCR2 Mammalian cell C-terminal 6xHis-Fc-tagged
Recombinant Mouse Hepatitis A virus cellular receptor 2 homolog (Havcr2), partial (Active) CSB-AP005341MO Havcr2 Mammalian cell C-terminal Fc-tagged
Recombinant Human Interleukin-15 receptor subunit alpha (IL15RA), partial (Active) CSB-AP004551HU IL15RA Mammalian cell C-terminal Fc-tagged
Recombinant Mouse Interleukin-15 receptor subunit alpha (Il15ra), partial (Active) CSB-AP004801MO Il15ra Mammalian cell C-terminal Fc-tagged

● 穩(wěn)定細(xì)胞株

CSB-SC004847HU2 FACS

CHOK1/Human CCR8 Stable Cell Line

CSB-SC004847HU2

Untransfected CHO-K1 cells (green line) and transfected Human CCR8 CHO-K1 stable cells (red line) were stained with anti-CCR8 antibody (CSB-RA004847A1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-SC004847HU3 FACS

CT26/Human CCR8 Stable Cell Line

CSB-SC004847HU3

Untransfected CT26 cells (green line) and transfected Human CCR8 CT26 Stable cells (red line) were stained with anti-CCR8 antibody (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-SC004847MO FACS

CHOK1/Mouse CCR8 Stable Cell Line

CSB-SC004847MO

Untransfected CHO-K1 cells (green line) and transfected Mouse CCR8 CHO-K1 Stable cells (red line) were stained with anti-Mouse CD198-PE antibody (2μg/1*106 cells) and analyzed with flow cytometry.

● 重組抗體

ALPP Recombinant Monoclonal Antibody
CSB-RA183247A0HU
CSB-RA183247A0HU FC

Overlay Peak curve showing HepG2 cells surface stained with CSB-RA183247A0HU (red line) at 1:50.

CCR8 Recombinant Monoclonal Antibody
CSB-RA004847A1HU
CSB-RA004847A1HU FC

Untransfected HEK293T cells surface (green line) and transfected Human CCR8 HEK293T stable cells surface (red line) were stained with anti-CCR8 antibody (2μg/1*106 cells)。

CEACAM5 Recombinant Monoclonal Antibody
CSB-RA005165MA3HU
CSB-RA005165MA3HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA005165MA3HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
ALPP Recombinant Monoclonal Antibody CSB-RA183247A0HU ALPP Human ELISA, WB, IHC, FC
CA9 Recombinant Monoclonal Antibody CSB-RA614990A0HU CA9 Human ELISA, IHC
CCR8 Recombinant Monoclonal Antibody CSB-RA004847A1HU CCR8 Human FC
CCR8 Recombinant Monoclonal Antibody CSB-RA004847MA3HU CCR8 Human FC
CCR8 Recombinant Monoclonal Antibody CSB-RA004847MA2HU CCR8 Human FC
CCR8 Recombinant Monoclonal Antibody CSB-RA004847MA4HU CCR8 Human FC
CD22 Recombinant Monoclonal Antibody CSB-RA962691A0HU CD22 Human ELISA, IHC
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA3HU CEACAM5 Human ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA1HU CEACAM5 Human ELISA
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
ENTPD1 Recombinant Monoclonal Antibody CSB-RA568544A0HU ENTPD1 Human ELISA, FC
ERBB2 Recombinant Monoclonal Antibody CSB-RA260392A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU ERBB2 Human ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody CSB-RA588766A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA2HU ERBB2 Human ELISA, IHC
ERBB3 Recombinant Monoclonal Antibody CSB-RA937008A0HU ERBB3 Human ELISA, IF
FLT1 Recombinant Monoclonal Antibody CSB-RA940669A0HU FLT1 Human, Mouse ELISA, WB, IHC, FC
IGF1R Recombinant Monoclonal Antibody CSB-RA011087MA1HU IGF1R Human ELISA, FC
IL17A Recombinant Monoclonal Antibody CSB-RA624104MA1HU IL17A Human ELISA
IL2RA Recombinant Monoclonal Antibody CSB-RA011649MA1HU IL2RA Human ELISA, IF
MUC16 Recombinant Monoclonal Antibody CSB-RA941216A0HU MUC16 Human ELISA, IHC
MUC16 Recombinant Monoclonal Antibody CSB-RA973154A0HU MUC16 Human ELISA, IHC
NECTIN4 Recombinant Monoclonal Antibody CSB-RA822274A0HU NECTIN4 Human ELISA
NT5E Recombinant Monoclonal Antibody CSB-RA978310A0HU NT5E Human ELISA, IHC
PDCD1 Recombinant Monoclonal Antibody CSB-RA240597A0HU PDCD1 Human ELISA, WB, IHC
TOP1 Recombinant Monoclonal Antibody CSB-RA792129A0HU TOP1 Human ELISA, WB, IHC, FC, IP

● ELISA試劑盒

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 檢測(cè)范圍 靈敏度
Human Placental alkaline phosphatase,PLAP ELISA Kit CSB-E09160h ALPP 84 pg/mL-2000 pg/mL 34 pg/mL
Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit CSB-EL002476HU AXL 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit CSB-EL002476MO AXL 31.25 pg/ml-2000 pg/ml 7.81 pg/ml
Human Carbonic Anhydrase 9(CA9) ELISA Kit CSB-E13266h CA9 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human CD226 antigen(CD226) ELISA kit CSB-EL004901HU CD226 0.9 ng/mL-60 ng/mL 0.22 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human carcinoembryonic antigen,CEA ELISA Kit CSB-E04767h CEACAM5 5 ng/mL-120 ng/mL 2 ng/mL
Mouse carcinoembryonic antign,CEA ELISA Kit CSB-E13925m CEACAM5 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Human Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6) ELISA kit CSB-EL005166HU CEACAM6 0.83 ng/mL-20 ng/mL 0.33 ng/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL
Human Ectonucleoside triphosphate diphosphohydrolase 1(ENTPD1) ELISA kit CSB-EL007690HU ENTPD1 23.44 pg/mL-1500 pg/mL 5.86 pg/mL
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit CSB-E11161h ERBB2 0.156 ng/mL-10 ng/mL 0.04 ng/mL
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit CSB-EL007765HU ERBB3 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse Vascular endothelial cell growth factor receptor 1,VEGFR-1/Flt1 ELISA kit CSB-E04762m FLT1 1.56 ng/mL-100 ng/mL 0.39 ng/mL
Rat Vascular endothelial cell growth factor receptor 1,VEGFR-1/Flt1 ELISA Kit CSB-E07350r FLT1 1.56 pg/mL-100 pg/mL 0.39 pg/mL
Human FMS-like tyrosine kinase 3,Flt3 ELISA Kit CSB-E04556h FLT3 62.5 pg/mL-4000 pg/mL 15.6 pg/mL