MASP2

MASP2，即甘露聚糖結(jié)合凝集素相關(guān)絲氨酸蛋白酶2，它是由人體編碼的蛋白質(zhì)，屬于補體系統(tǒng)的一部分。MASP2主要來源于肝臟，是凝集素途徑中的關(guān)鍵效應(yīng)酶。其作用機制是在凝集素途徑激活后，MASP2被甘露糖結(jié)合凝集素（MBL）或其他模式識別分子激活，進而裂解C4和C2，形成C3轉(zhuǎn)化酶，激活C3和C5，最終導(dǎo)致形成膜攻擊復(fù)合物（MAC），發(fā)揮溶細胞效應(yīng)。在信號通路方面，MASP2的激活是補體系統(tǒng)凝集素途徑的中心環(huán)節(jié)，通過其絲氨酸蛋白酶活性，MASP2參與調(diào)控免疫反應(yīng)和炎癥過程。在生物學(xué)意義上，MASP2對宿主的免疫防御至關(guān)重要，其功能異常與多種炎癥性疾病和自身免疫性疾病的發(fā)生發(fā)展相關(guān)。MASP2的活性調(diào)節(jié)為治療相關(guān)疾病提供了新的策略。

熱銷產(chǎn)品

Recombinant Human Mannan-binding lectin serine protease 2 (MASP2) (CSB-EP013510HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

MASP2 Antibody (CSB-PA013510LA01HU)

驗證數(shù)據(jù)

IHC image of CSB-PA013510LA01HU diluted at 1:100 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human mannan-binding lectin serine peptidase 2 (MASP2)ELISA kit (CSB-E17966h)

驗證數(shù)據(jù)

貨號：CSB-E17966h

規(guī)格：96T/48T

靈敏度：5.86 pg/mL

檢測范圍：23.44 pg/mL-1500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

MASP2 Antibody

MASP2 Protein

MASP2 ELISA Kit

MASP2 Antibodies

MASP2 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA943074	MASP2 Antibody	Human	ELISA,WB
CSB-PA006707	MASP2 Antibody	Human	WB, ELISA
CSB-PA178736	MASP2 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA159806	MASP2 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA013510LA01HU	MASP2 Antibody	Human	ELISA, IHC
CSB-PA013510LB01HU	MASP2 Antibody, HRP conjugated	Human	ELISA
CSB-PA013510LC01HU	MASP2 Antibody, FITC conjugated	Human
CSB-PA013510LD01HU	MASP2 Antibody, Biotin conjugated	Human	ELISA

MASP2 Proteins

MASP2 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP013510HU CSB-MP013510HU CSB-EP013510HU-B	Recombinant Human Mannan-binding lectin serine protease 2 (MASP2)	Yeast Mammalian cell In Vivo Biotinylation in E.coli
CSB-BP013510HU	Recombinant Human Mannan-binding lectin serine protease 2 (MASP2)	Baculovirus
CSB-EP013510HU	Recombinant Human Mannan-binding lectin serine protease 2 (MASP2)	E.coli

MASP2 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP856307MO CSB-EP856307MO-B	Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2)	Yeast In Vivo Biotinylation in E.coli
CSB-EP856307MO	Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2)	E.coli
CSB-BP856307MO	Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2)	Baculovirus
CSB-BP856307MOc7	Recombinant Mouse Mannan-binding lectin serine protease 2 (Masp2)	Baculovirus

MASP2 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP867502RA CSB-EP867502RA CSB-EP867502RA-B	Recombinant Rat Mannan-binding lectin serine protease 2 (Masp2)	Yeast E.coli In Vivo Biotinylation in E.coli
CSB-BP867502RA	Recombinant Rat Mannan-binding lectin serine protease 2 (Masp2)	Baculovirus