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CD70

CD70是CD27配體。它在免疫系統(tǒng)中發(fā)揮重要作用,特別是在T細(xì)胞的活化和增殖過(guò)程中。他的結(jié)構(gòu)包括一個(gè)胞外區(qū)域、可以與CD27受體結(jié)合,一個(gè)跨膜區(qū)域和一個(gè)胞漿區(qū)域。CD70的主要功能之一是通過(guò)與CD27受體相互作用來(lái)調(diào)節(jié)T細(xì)胞的活化和增殖。CD27是T細(xì)胞表面的一種分子,當(dāng)CD70與其結(jié)合時(shí),會(huì)激活多條信號(hào)通路,包括NF-κB、MAPK和PI3K-Akt等信號(hào)通路。這些信號(hào)通路的激活可以促進(jìn)細(xì)胞增殖、分化和功能發(fā)揮,從而加強(qiáng)免疫應(yīng)答。此外,CD70還可以影響其他免疫細(xì)胞,如B細(xì)胞和自然殺傷細(xì)胞的功能。因此,對(duì)其結(jié)構(gòu)、功能和信號(hào)通路的深入理解對(duì)于免疫調(diào)節(jié)和相關(guān)疾病的治療具有重要意義。

熱銷(xiāo)產(chǎn)品

Recombinant Human CD70 antigen (CD70), partial (Active)

驗(yàn)證數(shù)據(jù)

SDS
CSB-MP004954HU1 SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced/non-reduced) with 5% enrichment gel and 15% separation gel.

ELISA
CSB-MP004954HU1 ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD70 at 2 μg/ml can bind Anti-CD70 antibody, the EC50 is 2.414-3.196 ng/mL


CD70 Antibodies

CD70 for Homo sapiens (Human)

CD70 Proteins

CD70 Proteins for Homo sapiens (Human)

CD70 Proteins for Mus musculus (Mouse)

CD70 Proteins for Sus scrofa (Pig)

CD70 ELISA Kit

CD70 ELISA Kit for Homo sapiens (Human)

CD70 ELISA Kit for Mus musculus (Mouse)