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男性泌尿生殖器疾病

男性泌尿生殖器疾病包括多種影響男性生殖系統(tǒng)和泌尿系統(tǒng)的健康問題。這些疾病可能包括但不限于前列腺炎、前列腺增生、勃起功能障礙、睪丸炎、附睪炎、陰莖炎、尿路感染以及男性不育等。針對這些疾病,藥物研發(fā)涉及多個方面,包括病因治療、癥狀緩解和預(yù)防并發(fā)癥等。

目前男性泌尿生殖器疾病藥物研發(fā)主要集中在以下靶點:

  • EZH2:是一種組蛋白甲基轉(zhuǎn)移酶,在多種癌癥中高表達,促進癌癥發(fā)生和惡變。他澤司他(Tazemetostat)是一種EZH2抑制劑,能夠通過激活免疫系統(tǒng)來抑制膀胱癌,這為表觀遺傳藥物在膀胱癌治療中的應(yīng)用提供了新的方向。
  • KLK2:KLK2在前列腺癌中高度富集,JNJ-78278343是一種針對KLK2的候選藥物,正在開發(fā)用于治療轉(zhuǎn)移性去勢抵抗性前列腺癌(mCRPC)。
  • PSMA(前列腺特異性膜抗原):PSMA在前列腺癌細胞中高度表達,是前列腺癌治療和成像的潛在靶點。針對PSMA的藥物,包括一些新型的放射性配體療法,正在開發(fā)中。
  • AR(雄激素受體):雄激素受體在前列腺癌的發(fā)展中起關(guān)鍵作用,因此是內(nèi)分泌治療的重要靶點。新型的AR拮抗劑和降解劑正在研發(fā)中,以提高治療效果。
  • PARP(多聚ADP-核糖聚合酶):PARP抑制劑在治療轉(zhuǎn)移性去勢抵抗性前列腺癌(mCRPC)中顯示出潛力,它們通過抑制DNA修復(fù)機制來增強癌細胞對放療和某些化療藥物的敏感性。
  • VEGF(血管內(nèi)皮生長因子):VEGF在多種腫瘤的血管生成中起關(guān)鍵作用,靶向VEGF的藥物如貝伐珠單抗(Bevacizumab)已用于多種癌癥的治療,包括某些泌尿生殖系統(tǒng)腫瘤。
  • HER2:HER2在某些前列腺癌患者中過表達,針對HER2的抗體藥物偶聯(lián)物(ADCs)正在開發(fā)中。
  • c-MET:c-MET是一個酪氨酸激酶受體,在某些泌尿生殖系統(tǒng)腫瘤中過表達,可能成為治療的靶點。

男性泌尿生殖器疾病靶點相關(guān)產(chǎn)品推薦

● 靶點蛋白

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP006163HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP011649HU3 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP009411HU Activity Verified

Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP004954HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human CD70 at 2 μg/ml can bind Anti-CD70 antibody, the EC50 is 2.414-3.196 ng/mL.

產(chǎn)品名稱 貨號 靶點 來源 蛋白標簽
Recombinant Human Angiopoietin-2 (ANGPT2) (Active) CSB-MP001707HU(A4) ANGPT2 Mammalian cell C-terminal 10xHis-tagged
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active) CSB-MP001707DO ANGPT2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active) CSB-MP773799HU BTLA Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active) CSB-MP773799HU1 BTLA Mammalian cell C-terminal 10xHis-tagged
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active) CSB-AP005061HU CD19 Mammalian cell C-terminal Fc-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active) CSB-MP733578HU CD276 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-AP005191HU CD40LG E.coli Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-MP004937HU3 CD40LG Mammalian cell N-terminal hFc-Flag-tagged
Recombinant Human Membrane cofactor protein (CD46), partial (Active) CSB-MP004939HU CD46 Mammalian cell C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active) CSB-MP004954HU1 CD70 Mammalian cell N-terminal 10xHis-tagged
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active) CSB-AP005161HU CD86 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Claudin-6 (CLDN6)-VLPs (Active) CSB-MP005508HU(A4) CLDN6 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Claudin-6 (CLDN6)-VLPs, Fluorescent (Active) CSB-MP005508HU(A4)f4 CLDN6 Mammalian cell C-terminal GFP-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active) CSB-AP003591HU CSF2RA Mammalian cell C-terminal 6xHis-tagged

● 穩(wěn)定細胞株

CSB-SC005508HU FACS

HEK293T/Human CLDN6 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 antibody (CSB-RA005508MA1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-SC020067HU FACS

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-SC007681HU FACS

HEK293T/Human ENPP3 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human ENPP3 HEK293T Stable cells (red line) were stained with anti-ENPP3 antibody (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-SC882142HU FACS

HEK293F/Human DLL3 Stable Cell Line

CSB-SC882142HU

Untransfected HEK293 cells (green line) and transfected Human DLL3 HEK293 stable cells (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.

● 重組抗體

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU
CSB-RA244537A0HU FC

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

產(chǎn)品名稱 貨號 靶點 反應(yīng)種屬 應(yīng)用范圍
ALB Recombinant Monoclonal Antibody CSB-RA264109A0HU ALB Human ELISA, FC
ANGPT2 Recombinant Monoclonal Antibody CSB-RA191985A0HU ANGPT2 Human ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody CSB-RA001707MA01HU ANGPT2 Human ELISA
BTLA Recombinant Monoclonal Antibody CSB-RA773799MA1HU BTLA Human ELISA, FC
C3 Recombinant Monoclonal Antibody CSB-RA303909A0HU C3 Human ELISA, WB, IHC, FC
C3 Recombinant Monoclonal Antibody CSB-RA699863A0HU C3 Human ELISA, IHC
C5 Recombinant Monoclonal Antibody CSB-RA003995MA1HU C5 Human ELISA, FC
CA9 Recombinant Monoclonal Antibody CSB-RA614990A0HU CA9 Human ELISA, IHC
CCR2 Recombinant Monoclonal Antibody CSB-RA297464A0HU CCR2 Human ELISA, IHC
CD19 Recombinant Monoclonal Antibody CSB-RA004888A0HU CD19 Human ELISA
CD19 Recombinant Monoclonal Antibody CSB-RA780821A0HU CD19 Human ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody CSB-RA004888MA1HU CD19 Human, Mouse ELISA, WB
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD27 Recombinant Monoclonal Antibody CSB-RA953976A0HU CD27 Human ELISA, WB
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody CSB-RA796695A0HU CD38 Human ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody CSB-RA004931MA1HU CD3E Human ELISA, FC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD46 Recombinant Monoclonal Antibody CSB-RA908548A0HU CD46 Human ELISA, WB, IHC

● ELISA試劑盒

產(chǎn)品名稱 貨號 靶點 檢測范圍 靈敏度
Bovine Albumin(Alb) ELISA kit CSB-E08664b ALB 0.313 μg/mL-80 μg/mL 0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit CSB-E13878m ALB 0.781 μg/mL-200 μg/mL 0.110 μg/mL
Dog Albumin(Alb) ELISA Kit CSB-E15757c ALB 0.273 μg/mL-35 μg/mL 0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit CSB-E15839Sh ALB 350 μg/mL-21.88 μg/mL 5.5 μg/mL
Horse Albumin(Alb) ELISA Kit CSB-E16205Hs ALB 1.25 μg/mL-80 μg/mL 1.247 μg/mL
Pig Albumin (Alb) ELISA Kit CSB-E16207p ALB 0.03 μg/mL-7000 μg/mL 0.03 μg/mL
Goat Albumin (Alb)ELISA Kit CSB-E15758G ALB 0.17 μg/mL-350 μg/mL 0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit CSB-E15765Gp ALB 0.156 μg/mL-10 μg/mL 0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit CSB-E16204Rb ALB 0.273 μg/mL-70 μg/mL 0.117 μg/mL
Human Angiopoietin 2,ANG-2 ELISA Kit CSB-E04500h ANGPT2 39 pg/mL-2500 pg/mL 9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit CSB-E07304r ANGPT2 Request Information Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit CSB-E07305m ANGPT2 0.156 pg/mL-10 pg/mL 0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit CSB-E08460p ANGPT2 0.94 ng/mL-60 ng/mL 0.235 ng/mL
Human B- and T-lymphocyte attenuator(BTLA) ELISA kit CSB-EL002868HU BTLA 0.45 ng/mL-30 ng/mL 0.11 ng/mL
Mouse B- and T-lymphocyte attenuator(BTLA) ELISA kit CSB-EL002868MO BTLA 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human Complement C1s subcomponent(C1S) ELISA kit CSB-EL003657HU C1S 25 ng/mL-1600 ng/mL 6.25 ng/mL
Human Complement 3,C3 ELISA Kit CSB-E08665h C3 4.7 ng/mL-300 ng/mL 4.031 ng/mL
Pig Complement 3,C3 ELISA Kit CSB-E06920p C3 0.625 μg/mL-10 μg/mL 0.625 μg/mL
Rat Complement 3,C3 ELISA Kit CSB-E08666r C3 0.625 μg/mL-40 μg/mL 0.156 μg/mL
Mouse Complement 3,C3 ELISA Kit CSB-E08667m C3 93.75 ng/mL-6000 ng/mL 23.44 ng/mL
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