FCGR3A
FCGR3A,即Fc片段的IgG受體IIIa,別名CD16a。它是一種低親和力的IgG Fc區(qū)受體,屬于免疫球蛋白超家族成員,主要表達(dá)在自然殺傷(NK)細(xì)胞、巨噬細(xì)胞、肥大細(xì)胞和中性粒細(xì)胞等免疫效應(yīng)細(xì)胞表面。FCGR3A通過(guò)與IgG1和IgG3的Fc段結(jié)合,誘導(dǎo)免疫效應(yīng)細(xì)胞的細(xì)胞毒作用,即抗體依賴(lài)的細(xì)胞介導(dǎo)的細(xì)胞毒作用(ADCC),殺傷靶細(xì)胞,也可促進(jìn)IFN-γ、TNF和基質(zhì)金屬蛋白酶等細(xì)胞因子的分泌,影響細(xì)胞免疫功能發(fā)揮。FCGR3A在生物學(xué)上的意義主要體現(xiàn)在其參與的多種免疫反應(yīng)中。它不僅在NK細(xì)胞介導(dǎo)的ADCC中發(fā)揮作用,還是單克隆抗體介導(dǎo)的分子靶向治療的重要結(jié)合位點(diǎn),尤其在惡性腫瘤治療中應(yīng)用廣泛。此外,F(xiàn)CGR3A的基因多態(tài)性與某些癌癥的治療反應(yīng)相關(guān),其表達(dá)水平可能與腫瘤的預(yù)后相關(guān),有助于作為預(yù)后生物標(biāo)志物。FCGR3A的表達(dá)還與免疫檢查點(diǎn)分子以及腫瘤相關(guān)巨噬細(xì)胞(TAM)基因標(biāo)志物呈正相關(guān),表明其在腫瘤免疫微環(huán)境中可能發(fā)揮重要作用。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FCGR3A Recombinant Monoclonal Antibody (CSB-RA008543MA1HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescence staining of Hela cell with CSB-RA008543MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
FCGR3A Antibodies
FCGR3A for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
---|---|---|---|
CSB-PA287660 | FCGR3A Antibody | Human | ELISA,IHC |
CSB-PA183080 | FCGR3A Antibody | Human | ELISA,IHC |
CSB-PA008543LA01HU | FCGR3A Antibody | Human | ELISA, IHC, IF |
CSB-PA008543LB01HU | FCGR3A Antibody, HRP conjugated | Human | ELISA |
CSB-PA008543LC01HU | FCGR3A Antibody, FITC conjugated | Human | |
CSB-PA008543LD01HU | FCGR3A Antibody, Biotin conjugated | Human | ELISA |
CSB-RA008543MA1HU | FCGR3A Recombinant Monoclonal Antibody | Human | ELISA, IF |
FCGR3A Proteins
FCGR3A Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP008543HU1 CSB-EP008543HU1 CSB-BP008543HU1 CSB-MP008543HU1 CSB-EP008543HU1-B |
Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF008543HU | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A) | in vitro E.coli expression system |
CSB-AP005111HU | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), partial (Active) | Mammalian cell |
CSB-EP008543HU2 | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), partial | E.coli |
CSB-MP008543HU1(M) | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A)(F176V), partial (Active) | Mammalian cell |
CSB-MP008543HU1(M)k7 | Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A) (F176V), partial | Mammalian cell |
FCGR3A Proteins for Bos taurus (Bovine)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP303590BO CSB-EP303590BO CSB-BP303590BO CSB-MP303590BO CSB-EP303590BO-B |
Recombinant Bovine Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Macaca mulatta (Rhesus macaque)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP388701MOW CSB-EP388701MOW CSB-BP388701MOW CSB-MP388701MOW CSB-EP388701MOW-B |
Recombinant Macaca mulatta Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Sus scrofa (Pig)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP636747PI CSB-EP636747PI CSB-BP636747PI CSB-MP636747PI CSB-EP636747PI-B |
Recombinant Pig Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP854680MOV CSB-EP854680MOV CSB-BP854680MOV CSB-MP854680MOV CSB-EP854680MOV-B |
Recombinant Macaca fascicularis Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A ELISA Kit
FCGR3A ELISA Kit for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
---|---|---|---|
CSB-EL008543HU | Human Low affinity immunoglobulin gamma Fc region receptor III-A(FCGR3A) ELISA kit | serum, plasma, tissue homogenates | 11.75 pg/mL |