CD38
CD38是一種Ⅱ型跨膜糖蛋白,分子量為46kDa。1980年,CD38作為T細胞激活的特異性標記物,被E.L.Reinherz和S.F.Schlossman等科學家發(fā)現。CD38整體結構為N末端短的細胞質尾,單次跨膜域和C端較長的胞外區(qū)。CD38具有環(huán)化酶和水解酶的活性,是一種雙功能胞外酶,參與核苷酸代謝。CD38使用NAD+作為底物來形成環(huán)狀ADP核糖(cADPR)等核苷酸代謝產物。核苷酸代謝產物是有效的第二信使,可調節(jié)細胞質中Ca2+的動員,激活控制各種生物學過程的信號通路,例如淋巴細胞增殖、胰腺B細胞分泌胰島素、T細胞活化等。CD38的這種活性對于維持體內NAD、煙酰胺等物質的動態(tài)平衡非常重要。也有研究發(fā)現,CD38同CD39、CD73、CD203a等一起,可降解ATP、NAD+、cADPR、AMP,從而產生ADO,誘導抑制性的免疫微環(huán)境。
CD38在人多種組織中都有表達,包括淋巴細胞、自然殺傷細胞、T細胞、B細胞單核細胞/巨噬細胞胰腺、腦、脾臟和肝細胞等。CD38的表達與多種疾病有關,包括艾滋病、自身免疫性疾?。ɡ缦到y(tǒng)性紅斑狼瘡)、Ⅱ型糖尿病、骨質疏松癥和癌癥。近年來,以CD38為靶點的多種新型免疫治療方法已在臨床前模型和臨床試驗中得到驗證。2015年,強生公司聯合開發(fā)的全人源抗CD38抗體達雷妥尤單抗(Daratumumab, Darzalex)獲準用于治療復發(fā)型、耐藥型多發(fā)性骨髓瘤患者,是首個上市的CD38抗體藥物。2020年3月2日,賽諾菲研發(fā)的抗腫瘤藥物Isatuximab獲得FDA批準,是繼強生Darzalex之后第二款CD38抗體藥物,同樣是用于治療復發(fā)性難治性多發(fā)性骨髓瘤。目前,無論Daratumumab還Isatuximab在多發(fā)性骨髓瘤治療中均體現了顯著的療效。
熱銷產品
CD38 Antibody (WB, ELISA, IHC) (CSB-RA796695A0HU)
驗證數據
Positive WB detected in: THP-1 whole cell lysate
IHC image of CSB-RA796695A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system.
CD38 Antibodies
CD38 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA004929ESR1HU | CD38 Antibody | Human | ELISA, IHC |
CSB-PA005628 | CD38 Antibody | Human | WB, ELISA |
CSB-PA134528 | CD38 Antibody | Human | ELISA,WB |
CSB-PA926996 | CD38 Antibody | Human | ELISA,WB,IHC |
CSB-MA785760 | CD38 Monoclonal Antibody | Human | ELISA, IHC |
CSB-RA796695A0HU | CD38 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
CD38 Proteins
CD38 Proteins for Mus musculus (Mouse)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP004929MO1 CSB-EP004929MO1 CSB-BP004929MO1 CSB-MP004929MO1 CSB-EP004929MO1-B |
Recombinant Mouse ADP-ribosyl cyclase 1 (Cd38), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF004929MO | Recombinant Mouse ADP-ribosyl cyclase 1 (Cd38) | in vitro E.coli expression system |
CD38 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP722775MOV CSB-EP722775MOV CSB-BP722775MOV CSB-MP722775MOV CSB-EP722775MOV-B |
Recombinant Macaca fascicularis ADP-ribosyl cyclase 1 (CD38), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD38 Proteins for Rattus norvegicus (Rat)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP731039RA CSB-EP731039RA CSB-BP731039RA CSB-MP731039RA CSB-EP731039RA-B |
Recombinant Rat ADP-ribosyl cyclase 1 (Cd38), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD38 Proteins for Oryctolagus cuniculus (Rabbit)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP889007RB CSB-EP889007RB CSB-BP889007RB CSB-MP889007RB CSB-EP889007RB-B |
Recombinant Rabbit ADP-ribosyl cyclase 1 (CD38), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD38 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-CF004929HU | Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) | in vitro E.coli expression system |
CSB-EP004929HU1 CSB-BP004929HU1 CSB-EP004929HU1-B |
Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP004929HU1 | Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial | Mammalian cell |
CSB-YP004929HU1 | Recombinant Human ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38), partial | Yeast |
CD38 ELISA Kit
CD38 ELISA Kit for Homo sapiens (Human)
產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-E09884h | Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.225 ng/mL |
CD38 ELISA Kit for Mus musculus (Mouse)
產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-EL004929MO | Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit | serum, plasma, tissue homogenates | 0.156 ng/mL |