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內(nèi)分泌系統(tǒng)疾病

內(nèi)分泌系統(tǒng)疾病是一組影響內(nèi)分泌腺體正常功能的病狀,這些腺體包括但不限于甲狀腺、腎上腺、垂體和性腺等。這些疾病通常與激素分泌異常有關(guān),可能是激素水平過高或過低,導(dǎo)致身體多種生理功能失衡。

常見的內(nèi)分泌系統(tǒng)疾病包括糖尿病、甲狀腺功能異常(包括甲亢和甲減)、腎上腺疾?。ㄈ绨仙『蛶煨谰C合征)、垂體功能障礙、性腺疾病(如多囊卵巢綜合征)、骨質(zhì)疏松癥和肥胖癥等。

內(nèi)分泌系統(tǒng)疾病的藥物研針對不同疾病和病理機制,有多個靶點和治療策略。以下是一些主要疾病的藥物研發(fā)進展及其對應(yīng)的靶點:

  • 糖尿?。?/b> 糖尿病藥物研發(fā)主要靶點包括胰島素分泌、胰島素抵抗、GLP-1受體、SGLT2等,現(xiàn)已開發(fā)了GLP-1受體激動劑(如利拉魯肽),SGLT2抑制劑(如達格列凈),以及新型胰島素類似物,這些藥物通過不同機制降低血糖水平。
  • 甲狀腺疾?。?/b>甲狀腺疾病藥物研發(fā)主要靶點包括甲狀腺激素合成、甲狀腺激素受體、TSH受體等。目前甲亢的治療中,已采用β-阻滯劑(如普萘洛爾)和抗甲狀腺藥物(如甲巰咪唑)。甲減的治療則依賴于甲狀腺激素替代療法。
  • 庫欣綜合征:庫欣綜合征藥物研發(fā)主要靶向皮質(zhì)醇合成和皮質(zhì)醇受體。治療可能包括使用皮質(zhì)醇合成抑制劑(如酮康唑)和皮質(zhì)醇受體拮抗劑(如米非司酮)。
  • 生長激素異常:生長激素異常藥物研發(fā)主要靶向生長激素分泌和生長激素受體。生長激素缺乏癥的治療使用重組人生長激素,而肢端肥大癥可能使用生長激素受體拮抗劑(如培維索孟)。
  • 肥胖癥:生長激素異常藥物研發(fā)主要針對食欲控制、能量消耗、脂肪吸收。新型藥物(如塞美拉肽)通過模擬GLP-1的作用減少饑餓感和食物攝入。

內(nèi)分泌系統(tǒng)疾病靶點相關(guān)產(chǎn)品推薦

● 靶點蛋白

CSB-MP009514HUb1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.

CSB-MP009411HU Activity Verified

Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP005498HU(A5) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml.

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP009316HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human GCGR at 2 μg/ml can bind Anti-GCGR recombinant antibody (CSB-RA009316A1HU), the EC50 is 3.747-6.666 ng/mL.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

產(chǎn)品名稱 貨號 靶點 來源 蛋白標(biāo)簽
Recombinant Human ATP-binding cassette sub-family D member 1 (ABCD1) (Active) CSB-CF001068HU ABCD1 in vitro E.coli expression system C-terminal 10xHis-tagged
Recombinant Human Angiopoietin-2 (ANGPT2) (Active) CSB-MP001707HU(A4) ANGPT2 Mammalian cell C-terminal 10xHis-tagged
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active) CSB-MP001707DO ANGPT2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active) CSB-MP733578HU CD276 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-AP005191HU CD40LG E.coli Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-MP004937HU3 CD40LG Mammalian cell N-terminal hFc-Flag-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human Cadherin-17 (CDH17), partial (Active) CSB-MP613267HU CDH17 Mammalian cell C-terminal?10xHis-tagged
Recombinant Macaca fascicularis Cadherin 17 (CDH17), partial (Active) CSB-MP4664MOV CDH17 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) CSB-MP005165HU CEACAM5 Mammalian cell C-terminal?10xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) (Active) CSB-MP005166HU CEACAM6 Mammalian cell C-terminal 10xHis-tagged
Recombinant Macaca fascicularis Claudin (CLDN18)-VLPs (Active) CSB-MP4304MOV CLDN18 Mammalian cell N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Mouse Claudin-18 (Cldn18)-VLPs (Active) CSB-MP005498MO(F3) Cldn18 Mammalian cell N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Claudin-6 (CLDN6)-VLPs (Active) CSB-MP005508HU(A4) CLDN6 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Claudin-6 (CLDN6)-VLPs, Fluorescent (Active) CSB-MP005508HU(A4)f4 CLDN6 Mammalian cell C-terminal GFP-tagged (This tag can be tested only under denaturing conditions)

● 穩(wěn)定細胞株

CSB-SC005508HU FACS

HEK293T/Human CLDN6 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 antibody (CSB-RA005508MA1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-SC613267HU2 FACS

HEK293T/Human CDH17 Stable Cell Line

CSB-SC613267HU2

Untransfected HEK293T cells (green line) and transfected Human CDH17 HEK293T stable cells (red line) were stained with anti-CDH17 antibody (CSB-RA613267MA1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

CLDN18 Recombinant Monoclonal Antibody
CSB-RA005498A2HU
CSB-RA005498A2HU FC

Untransfected KATO3 cells surface (green line), transfected Human CLDN18.2 KATO3 stable cells surface (red line) and transfected Human CLDN18.1 NIH-3T3 stable cells surface (blue line) were stained with anti-CLDN18.2 antibody (2μg/1*106 cells).

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU
CSB-RA244537A0HU FC

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

IGF1R Recombinant Monoclonal Antibody
CSB-RA011087MA1HU
CSB-RA011087MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.

產(chǎn)品名稱 貨號 靶點 反應(yīng)種屬 應(yīng)用范圍
ANGPT2 Recombinant Monoclonal Antibody CSB-RA191985A0HU ANGPT2 Human ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody CSB-RA001707MA01HU ANGPT2 Human ELISA
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CDH17 Recombinant Monoclonal Antibody CSB-RA613267MA1HU CDH17 Human ELISA,F(xiàn)C
CDH6 Recombinant Monoclonal Antibody CSB-RA005055MA1HU CDH6 Human ELISA
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA3HU CEACAM5 Human ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA1HU CEACAM5 Human ELISA
CLDN18 Recombinant Monoclonal Antibody CSB-RA005498A2HU CLDN18 Human ELISA, FC
Claudin-18.2 Recombinant Monoclonal Antibody CSB-RA005498A1HU CLDN18 Human ELISA, FC
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC

● ELISA試劑盒

產(chǎn)品名稱 貨號 靶點 檢測范圍 靈敏度
Human Angiopoietin 2,ANG-2 ELISA Kit CSB-E04500h ANGPT2 39 pg/mL-2500 pg/mL 9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit CSB-E07304r ANGPT2 Request Information Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit CSB-E07305m ANGPT2 0.156 pg/mL-10 pg/mL 0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit CSB-E08460p ANGPT2 0.94 ng/mL-60 ng/mL 0.235 ng/mL
Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit CSB-EL002476HU AXL 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit CSB-EL002476MO AXL 31.25 pg/ml-2000 pg/ml 7.81 pg/ml
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit CSB-E14285h CD276 3.12 ng/mL-200 ng/mL 0.78 ng/mL
Human soluble cluster of differentiation 28,sCD28 ELISA Kit CSB-E09296h CD28 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit CSB-E04716h CD40LG 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit CSB-E04717m CD40LG 0.274 ng/ml-200 ng/ml. 0.274 ng/ml.
Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit CSB-E07395r CD40LG 1.87 ng/mL-120 ng/mL 0.47 ng/mL
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human carcinoembryonic antigen,CEA ELISA Kit CSB-E04767h CEACAM5 5 ng/mL-120 ng/mL 2 ng/mL
Mouse carcinoembryonic antign,CEA ELISA Kit CSB-E13925m CEACAM5 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Human Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6) ELISA kit CSB-EL005166HU CEACAM6 0.83 ng/mL-20 ng/mL 0.33 ng/mL
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