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TNF

TNF,即腫瘤壞死因子。TNF是一種主要由活化的巨噬細胞產生的重要細胞因子,屬于多肽類激素。它在人體免疫系統(tǒng)中發(fā)揮著關鍵作用,尤其是在炎癥反應和細胞凋亡的調控中。TNF的作用機制涉及與細胞表面的TNF受體(TNFR)結合,主要包括TNFR1和TNFR2兩種類型。這種結合激活了多種下游信號通路,包括NF-κB、MAPK和JNK等,這些信號通路進一步調控細胞的存活、增殖、分化和死亡。TNF的生物學意義主要體現在其對炎癥反應的調控和在免疫應答中的作用。作為炎癥過程中的關鍵介質,TNF能夠促進炎癥細胞的聚集和活化,調節(jié)細胞因子的產生,以及影響血管的通透性。此外,TNF還參與調節(jié)細胞的凋亡過程,對腫瘤細胞具有抑制作用,這也是其名稱中“腫瘤壞死因子”的由來。然而,TNF的過度表達或異常調節(jié)與多種疾病有關,包括自身免疫性疾病、慢性炎癥和某些類型的癌癥,因此,針對TNF的拮抗劑已成為治療這些疾病的有效手段。

熱銷產品

Recombinant Human Tumor necrosis factor (TNF), partial (Active) (CSB-YP023955HU)

驗證數據

CSB-YP023955HU

Activity
Measured in a cytotoxicity assay using L?929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The EC50 for this effect is 33.32-47.38 pg/mL.

CSB-YP023955HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TNF Antibodies

TNF for Sheep

TNF for Bovine

TNF for Homo sapiens (Human)

TNF for H,R,M

TNF Proteins

TNF Proteins for Bos taurus (Bovine)

TNF Proteins for Capra hircus (Goat)

TNF Proteins for Felis catus (Cat) (Felis silvestris catus)

TNF Proteins for Sus scrofa (Pig)

TNF Proteins for Equus caballus (Horse)

TNF Proteins for Cavia porcellus (Guinea pig)

TNF Proteins for Macaca mulatta (Rhesus macaque)

TNF Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

TNF Proteins for Mus musculus (Mouse)

TNF Proteins for Oryctolagus cuniculus (Rabbit)

TNF Proteins for Trichosurus vulpecula (Brush-tailed possum)

TNF Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

TNF Proteins for Rattus norvegicus (Rat)

TNF Proteins for Papio sp. (Baboon)

TNF Proteins for Peromyscus leucopus (White-footed mouse)

TNF Proteins for Cervus elaphus (Red deer)

TNF Proteins for Bos indicus (Zebu)

TNF Proteins for Bubalus bubalis (Domestic water buffalo)

TNF Proteins for Lama glama (Llama)

TNF Proteins for Papio anubis (Olive baboon)

TNF Proteins for Marmota monax (Woodchuck)

TNF Proteins for Papio hamadryas ursinus (Chacma baboon)

TNF Proteins for Macropus eugenii (Tammar wallaby)

TNF Proteins for Callithrix jacchus (White-tufted-ear marmoset)

TNF Proteins for Boselaphus tragocamelus (Nilgai)

TNF Proteins for Dasypus novemcinctus (Nine-banded armadillo)

TNF Proteins for Bubalus carabanensis (Swamp type water buffalo) (Bubalus bubalis carabanensis)

TNF Proteins for Tupaia tana (Large tree shrew)

TNF Proteins for Camelus bactrianus (Bactrian camel)

TNF Proteins for Pan troglodytes (Chimpanzee)

TNF Proteins for Sparus aurata (Gilthead sea bream)

TNF Proteins for Saimiri sciureus (Common squirrel monkey)

TNF Proteins for Delphinapterus leucas (Beluga whale)

TNF Proteins for Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)

TNF Proteins for Ovis aries (Sheep)

TNF Proteins for Homo sapiens (Human)

TNF ELISA Kit

TNF ELISA Kit for Bos taurus (Bovine)

TNF ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

TNF ELISA Kit for Capra hircus (Goat)

TNF ELISA Kit for Guinea Sus scrofa (Pig)

TNF ELISA Kit for Equus caballus (Horse)

TNF ELISA Kit for Homo sapiens (Human)

TNF ELISA Kit for Monkey

TNF ELISA Kit for Mus musculus (Mouse)

TNF ELISA Kit for Oryctolagus cuniculus (Rabbit)

TNF ELISA Kit for Rattus norvegicus (Rat)

TNF ELISA Kit for Ovis aries (Sheep)

TNF ELISA Kit for Sus scrofa (Pig)