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HAVCR2

HAVCR2,即甲型肝炎病毒細(xì)胞受體2,別名TIM-3(T細(xì)胞免疫球蛋白域和粘蛋白域-3)。它是一種主要在T細(xì)胞上表達(dá)的跨膜蛋白,屬于TIM家族成員之一。HAVCR2的作用機(jī)制涉及到與多種配體的結(jié)合,包括磷酸酶CD244和磷脂酰絲氨酸(PS),在免疫應(yīng)答中發(fā)揮調(diào)節(jié)作用,特別是作為抑制性受體參與調(diào)節(jié)T細(xì)胞的活性。HAVCR2在自身免疫性疾病、感染性疾病、腫瘤免疫監(jiān)視和免疫逃逸等免疫反應(yīng)的調(diào)節(jié)中發(fā)揮著不同的作用,是適應(yīng)性免疫中的一種抑制分子,且在某些腫瘤中表達(dá)水平的變化與疾病進(jìn)展相關(guān),因此它也是免疫治療研究中的潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (CSB-EP010145HU)

驗(yàn)證數(shù)據(jù)

CSB-EP010145HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

HAVCR2 Recombinant Monoclonal Antibody (CSB-RA010145MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA010145MA1HU

Immunofluorescence staining of Hela cell with CSB-RA010145MA1HU at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Human IgG(H+L).

Human Hepatitis A virus cellular receptor 2(HAVCR2) ELISA kit (CSB-EL010145HU)

驗(yàn)證數(shù)據(jù)

CSB-EL010145HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL010145HU

規(guī)格:96T/48T

靈敏度:11.75 pg/mL

檢測(cè)范圍:47 pg/mL-3000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

HAVCR2 Antibodies

HAVCR2 for Homo sapiens (Human)

HAVCR2 Proteins

HAVCR2 Proteins for Rattus norvegicus (Rat)

HAVCR2 Proteins for Homo sapiens (Human)

HAVCR2 Proteins for Mus musculus (Mouse)

HAVCR2 ELISA Kit

HAVCR2 ELISA Kit for Homo sapiens (Human)