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前列腺癌

前列腺癌是男性生殖系統(tǒng)中最常見的惡性腫瘤之一,尤其在65歲及以上的男性群體里更為常見。前列腺癌的生長(zhǎng)速度通常較慢,許多患者在一生中可能不會(huì)因前列腺癌而受到影響。然而,對(duì)于晚期或轉(zhuǎn)移性前列腺癌,治療選擇有限,預(yù)后較差。

治療前列腺癌的方法包括手術(shù)、放療、化療、激素治療等。近年來,前列腺癌的治療領(lǐng)域取得了顯著進(jìn)展,特別是在靶向治療和免疫治療方面。例如,雄激素受體抑制劑如恩扎盧胺(enzalutamide)等藥物的研發(fā)和應(yīng)用,為晚期前列腺癌患者提供了新的治療選擇。此外,針對(duì)程序性死亡受體(PD-1)或程序性死亡配體(PD-L1)信號(hào)通路的免疫檢查點(diǎn)阻斷療法,也在治療前列腺癌方面顯示出潛力。

最新的研究還發(fā)現(xiàn),分泌蛋白Gremlin1作為FGFR1的新型配體,通過FGFR1/MAPK信號(hào)通路調(diào)控腫瘤細(xì)胞可塑性,促進(jìn)去勢(shì)抵抗性前列腺癌(CRPC)的發(fā)生發(fā)展。這為靶向治療CRPC提供了新的候選藥物和治療策略。

前列腺癌藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP006163HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP733578HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC50 of human CD276 protein is 1.961-2.243 ng/ml.

CSB-MP004939HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD46 at 2 μg/ml can bind Anti-CD46 rabbit monoclonal antibody, the EC50 of human CD46 protein is 0.8333-1.054 ng/ml.

CSB-MP723415HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized DLL3 at 2 μg/ml can bind Anti-DLL3 Recombinant Antibody (CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL.

CSB-MP882142HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized DLL3 at 2 μg/ml can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 來源 蛋白標(biāo)簽
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active) CSB-MP733578HU CD276 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Membrane cofactor protein (CD46), partial (Active) CSB-MP004939HU CD46 Mammalian cell C-terminal hFc-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human Delta-like protein 3 (DLL3), partial (Active) CSB-MP882142HU DLL3 Mammalian cell C-terminal 6xHis-tagged
Recombinant Macaca fascicularis Delta-like protein 3 (DLL3), partial (Active) CSB-MP3536MOV DLL3 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) CSB-MP007765HU ERBB3 Mammalian cell C-terminal hFc-tagged
Recombinant Human 5'-nucleotidase (NT5E), partial (Active) CSB-AP005071HU NT5E Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse 5'-nucleotidase (Nt5e), partial (Active) CSB-AP005101MO Nt5e Mammalian cell C-terminal 6xHis-tagged
Recombinant Human 5'-nucleotidase (NT5E) (Active) CSB-MP723415HU NT5E Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Programmed cell death protein 1 (PDCD1), partial (Active) CSB-MP619964HU1 PDCD1 Mammalian cell C-terminal 6xHis-tagged

● 穩(wěn)定細(xì)胞株

CSB-SC882142HU FACS

HEK293F/Human DLL3 Stable Cell Line

CSB-SC882142HU

Untransfected HEK293 cells (green line) and transfected Human DLL3 HEK293 stable cells (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.

● 重組抗體

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU
CSB-RA004936MA1HU FC

Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CDH6 Recombinant Monoclonal Antibody CSB-RA005055MA1HU CDH6 Human ELISA
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody CSB-RA260392A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU ERBB2 Human ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody CSB-RA588766A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA2HU ERBB2 Human ELISA, IHC
FGFR3 Recombinant Monoclonal Antibody CSB-RA555849A0HU FGFR3 Human ELISA, IF
FGFR3 Recombinant Monoclonal Antibody CSB-RA966627A0HU FGFR3 Human ELISA, WB
IFNAR1 Recombinant Monoclonal Antibody CSB-RA011046A0HU IFNAR1 Human ELISA

● ELISA試劑盒

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 檢測(cè)范圍 靈敏度
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human Soluble CD276,sCD276/sB7-H3 ELISA kit CSB-E14285h CD276 3.12 ng/mL-200 ng/mL 0.78 ng/mL
Human soluble cluster of differentiation 28,sCD28 ELISA kit CSB-E09296h CD28 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human Soluble Cluster of differentiation 38,sCD38 ELISA kit CSB-E09884h CD38 0.9 ng/mL-60 ng/mL 0.225 ng/mL
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit CSB-EL004929MO CD38 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human membrane cofactor protein,MCP ELISA kit CSB-E09216h CD46 3.12 ng/mL-200 ng/mL 0.78 ng/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA kit CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA kit CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Human Delta-like protein 3(DLL3) ELISA kit CSB-EL006948HU DLL3 18.75 pg/mL-1200 pg/mL 4.68 pg/mL
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA kit CSB-E11161h ERBB2 0.156 ng/mL-10 ng/mL 0.04 ng/mL
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit CSB-EL007765HU ERBB3 125 pg/mL-8000 pg/mL 31.25 pg/mL
Human Glutamate carboxypeptidase 2(FOLH1) ELISA kit CSB-EL008782HU FOLH1 4.7 ng/mL-300 ng/mL 1.2 ng/mL
Human insulin-like growth factors 1 receptor,IGF-1R ELISA kit CSB-E13766h IGF1R 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Rat Insulin-like Growth Factors 1 Receptor,IGF-1R ELISA kit CSB-E13873r IGF1R 3.12 pg/mL-200 pg/mL 0.8 pg/mL
Bovine Interleukin 12,IL-12 ELISA kit CSB-E14010B IL12A 6.25 pg/mL-400 pg/mL 1.56 pg/mL
Human Kallikrein 2(hK 2) ELISA kit CSB-E13094h KLK2 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Mouse Programmed Death 1(PD-1)ELISA kit CSB-E13586m PDCD1 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Human Programmed Death 1(PD-1)ELISA kit CSB-E13643h PDCD1 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Vascular Endothelial cell Growth Factor,VEGF ELISA kit CSB-E04756m VEGFA 3.906 pg/mL-250 pg/mL 0.857 pg/mL
Human Vascular Endothelial cell Growth Factor(VEGF) ELISA kit CSB-E11718h VEGFA 31.25 pg/mL-2000 pg/mL 25.297 pg/mL
Rat Vascular Endothelial cell Growth Factor,VEGF ELISA kit CSB-E04757r VEGFA 3.9 pg/mL-250 pg/mL 0.97 pg/mL
Dog Vascular Endothelial cell Growth Factor,VEGF ELISA kit CSB-E11744c VEGFA 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Pig Vascular Endothelial cell Growth Factor,VEGF ELISA kit CSB-E12053p VEGFA 4.69 pg/mL-300 pg/mL 1.17 pg/mL
Bovine Vascular endothelial growth factor A(VEGFA) ELISA kit CSB-EL025833BO VEGFA 47 pg/mL-3000 pg/mL 11.75 pg/mL