IL18
IL18，即白介素18，它是一種在人體中由IL18基因編碼的細(xì)胞因子，屬于IL-1家族成員。IL18在多種細(xì)胞類型中表達(dá)，包括T細(xì)胞、NK細(xì)胞、樹突狀細(xì)胞等。其作用機(jī)制涉及到與IL18受體結(jié)合，該受體由α鏈和β鏈組成，其中α鏈負(fù)責(zé)配體結(jié)合，β鏈介導(dǎo)信號(hào)傳導(dǎo)。IL18通過與其受體結(jié)合，激活下游的信號(hào)傳導(dǎo)途徑，如通過JAK/STAT通路，進(jìn)而影響細(xì)胞的增殖、分化和效應(yīng)功能。IL18在生物學(xué)上的意義主要體現(xiàn)在其作為免疫調(diào)節(jié)因子參與炎癥和免疫應(yīng)答過程。它能誘導(dǎo)T細(xì)胞產(chǎn)生干擾素-γ（IFN-γ），促進(jìn)NK細(xì)胞和其他免疫細(xì)胞的活化，以及刺激細(xì)胞因子如腫瘤壞死因子-α（TNF-α）、IL-1β等的產(chǎn)生。IL18在促進(jìn)Th1型免疫應(yīng)答中發(fā)揮重要作用，并與多種炎癥性疾病、腫瘤和自身免疫性疾病的發(fā)生發(fā)展密切相關(guān)。例如，IL18的表達(dá)水平在某些自身免疫疾病中升高，可能作為疾病活動(dòng)性的標(biāo)志。此外，IL18的成熟過程涉及非經(jīng)典炎癥小體途徑，其中caspase-4/5的活化可以切割前體IL18，釋放其成熟形式以發(fā)揮生物學(xué)功能。
熱銷產(chǎn)品
Recombinant Human Interleukin-18 (IL18) (CSB-EP614514HUd7)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL18 Antibody (CSB-PA614514YA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA614514YA01HU at dilution of 1:20
Human Interleukin 18,IL-18 ELISA KIT (CSB-E07450h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E07450h
規(guī)格：96T/48T
靈敏度：7.8 pg/mL
檢測(cè)范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
IL18 Antibodies
IL18 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011608GA01HU | IL18 Antibody | Human, Rat | ELISA,WB,IHC,IF |
| CSB-PA614514YA01HU | IL18 Antibody | Human | ELISA, IHC |
| CSB-PA614514YD01HU | IL18 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA614514YC01HU | IL18 Antibody, FITC conjugated | Human | |
| CSB-PA614514YB01HU | IL18 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA08377A0Rb | IL18 Antibody | Human | ELISA |
| CSB-PA08377B0Rb | IL18 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA08377C0Rb | IL18 Antibody, FITC conjugated | Human | |
| CSB-PA08377D0Rb | IL18 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA081015 | IL18 Antibody | Human | ELISA,WB,IHC |
| CSB-PA634259 | IL18 Antibody | Human | ELISA,WB,IHC |
IL18 for Dog
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA895937LA01DO | IL18 Antibody | Dog | ELISA |
IL18 Proteins
IL18 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011608MO | Recombinant Mouse Interleukin-18 (Il18) | Yeast |
| CSB-EP011608MO | Recombinant Mouse Interleukin-18 (Il18) | E.coli |
| CSB-BP011608MO CSB-MP011608MO CSB-EP011608MO-B |
Recombinant Mouse Interleukin-18 (Il18) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP011608MOe1 | Recombinant Mouse Interleukin-18 (Il18) | Yeast |
| CSB-YP011608MOb0 | Recombinant Mouse Interleukin-18 (Il18) | Yeast |
| CSB-EP011608MOe1 | Recombinant Mouse Interleukin-18 (Il18) | E.coli |
IL18 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011608RA CSB-EP011608RA CSB-BP011608RA CSB-MP011608RA CSB-EP011608RA-B |
Recombinant Rat Interleukin-18 (Il18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP176194r | Recombinant Rat Interleukin-18 (Il18) | E.coli |
IL18 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011608PI CSB-EP011608PI CSB-BP011608PI CSB-MP011608PI CSB-EP011608PI-B |
Recombinant Pig Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP614514HU | Recombinant Human Interleukin-18 (IL18) | Yeast |
| CSB-EP614514HU CSB-BP614514HU CSB-MP614514HU CSB-EP614514HU-B |
Recombinant Human Interleukin-18 (IL18) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP614514HU(A4) | Recombinant Human Interleukin-18 (IL18) | Yeast |
| CSB-EP614514HU(A4) | Recombinant Human Interleukin-18 (IL18) | E.coli |
| CSB-EP614514HUd7 | Recombinant Human Interleukin-18 (IL18) | E.coli |
| CSB-EP614514HUc7 | Recombinant Human Interleukin-18 (IL18) | E.coli |
IL18 Proteins for Capra hircus (Goat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP672507GO CSB-EP672507GO CSB-BP672507GO CSB-MP672507GO CSB-EP672507GO-B |
Recombinant Goat Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Boselaphus tragocamelus (Nilgai)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP689269BUN CSB-EP689269BUN CSB-BP689269BUN CSB-MP689269BUN CSB-EP689269BUN-B |
Recombinant Boselaphus tragocamelus Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP819130CH CSB-EP819130CH CSB-BP819130CH CSB-MP819130CH CSB-EP819130CH-B |
Recombinant Chicken Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP850184CA CSB-EP850184CA CSB-BP850184CA CSB-MP850184CA CSB-EP850184CA-B |
Recombinant Cat Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP866143BO CSB-EP866143BO CSB-BP866143BO CSB-MP866143BO CSB-EP866143BO-B |
Recombinant Bovine Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP895012HO CSB-EP895012HO CSB-BP895012HO CSB-MP895012HO CSB-EP895012HO-B |
Recombinant Horse Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP895937DO CSB-BP895937DO CSB-MP895937DO CSB-EP895937DO-B |
Recombinant Dog Interleukin-18 (IL18) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP895937DO | Recombinant Dog Interleukin-18 (IL18) | E.coli |
IL18 ELISA Kit
IL18 ELISA Kit for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011608BO | Bovine Interleukin-18(IL18) ELISA kit | serum, plasma, tissue homogenates | 7.81 pg/mL |
IL18 ELISA Kit for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E10070Ch | Chicken Interleukin 18,IL-18 ELISA KIT | serum, plasma, tissue Homogenates | 1.95 pg/mL |
IL18 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09848c | Dog Interleukin 18,IL-18 ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates | 3.12 pg/mL |
IL18 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07450h | Human Interleukin 18,IL-18 ELISA KIT | serum, plasma, urine, tissue homogenates | 7.8 pg/mL |
IL18 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04609m | Mouse Interleukin 18,IL-18 ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.39 pg/mL |
IL18 ELISA Kit for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E06781p | Pig Interleukin 18,IL-18 ELISA Kit | serum, plasma, tissue homogenates | 7.81 pg/mL |
IL18 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04610r | Rat Interleukin 18,IL-18 Elisa Kit | serum, plasma, cell culture supernates | 0.039 ng/mL |
