ERBB2
人表皮生長(zhǎng)因子受體2（HER2，也稱ERBB2）是表皮生長(zhǎng)因子受體家族中的一員。HER2具有酪氨酸激酶活性，在組織發(fā)育中起至關(guān)重要的作用，是胚胎發(fā)育所必需的。然而，HER2的過(guò)表達(dá)往往會(huì)引起正常生物學(xué)功能的紊亂。ERBB2尚沒(méi)有已知的配體，必須與家族其他成員組成同源或異源二聚體，激活胞內(nèi)的酪氨酸激酶活性，從而啟動(dòng)下游信號(hào)傳導(dǎo)通路RAS-RAF-MEK-ERK以及PI3K-AKT-mTOR通路。越來(lái)越多的研究發(fā)現(xiàn)HER2與多種癌癥相關(guān)，包括乳腺癌、胃癌、結(jié)腸癌、膀胱癌、卵巢癌、子宮內(nèi)膜癌、肺癌等。其中，HER-2在乳腺癌和胃癌中的研究最為成熟。目前，HER2靶向藥物治療乳腺癌已取得顯著的臨床療效，數(shù)據(jù)表明曲妥珠單抗，T-DM1，帕妥珠單抗在治療過(guò)表達(dá)HER2的乳腺癌中，對(duì)患者預(yù)后有顯著的改善作用。此外，針對(duì)胃癌、結(jié)直腸癌的研究也在進(jìn)行中。
熱銷產(chǎn)品
● Recombinant Human Receptor tyrosine-protein kinase erbB-2(ERBB2),partial (Active)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.
● ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU
驗(yàn)證數(shù)據(jù)
The Binding Activity of Human ERBB2 with Anti-ERBB2 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ERBB2 (CSB-MP007763HU) at 2 μg/mL can bind Anti-ERBB2 recombinant antibody, the EC50 is 2.455-3.565 ng/mL.
● ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA2HU
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA007763MA2HU diluted at 1:600 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
ERBB2 Antibodies
ERBB2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007763GA01HU | ERBB2 Antibody | Human | ELISA,WB,IHC |
| CSB-PA09759C0Rb | ERBB2 Antibody, FITC conjugated | Human | |
| CSB-PA09759D0Rb | ERBB2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA007763KA01HU | ERBB2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA09759B0Rb | ERBB2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA09759A0Rb | ERBB2 Antibody | Human | ELISA, IHC |
| CSB-PA846722 | Phospho-ERBB2 (Tyr877) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA281422 | Phospho-ERBB2 (Tyr1221/Tyr1222) Antibody | Human | ELISA,WB,IF |
| CSB-PA997735 | Phospho-ERBB2 (Tyr1248) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA200841 | ERBB2 (Ab-877) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA899547 | ERBB2 (Ab-1221/1222) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA115264 | ERBB2 (Ab-1248) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA761682 | Phospho-ERBB2 (Tyr1112) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000577 | Phospho-ERBB2 (Y1221/Y1222) Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
| CSB-PA000578 | Phospho-ERBB2 (Y877) Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
| CSB-PA000733 | Phospho-ERBB2 (Y1221/Y1222) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
| CSB-PA003405 | ERBB2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA003407 | ERBB2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008077 | Phospho-ERBB2 (Y1248) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA008078 | Phospho-ERBB2 (Y1112) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008079 | Phospho-ERBB2 (T686) Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA008081 | ERBB2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008088 | ERBB2 Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA008089 | ERBB2 Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA008092 | ERBB2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA972166 | ERBB2 Antibody | Human | ELISA,WB |
| CSB-RA260392A0HU | ERBB2 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
ERBB2 for H, M, R
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-MA000200 | ERBB2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
ERBB2 for H
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-MA000237 | ERBB2 Monoclonal Antibody | Human | ELISA,WB |
ERBB2 Proteins
ERBB2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP007763MO CSB-EP007763MO CSB-BP007763MO CSB-MP007763MO CSB-EP007763MO-B |
Recombinant Mouse Receptor tyrosine-protein kinase erbB-2 (Erbb2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERBB2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP007763RA CSB-EP007763RA CSB-BP007763RA CSB-MP007763RA CSB-EP007763RA-B |
Recombinant Rat Receptor tyrosine-protein kinase erbB-2 (Erbb2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERBB2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP007763HU CSB-BP007763HU CSB-EP007763HU-B |
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP007763HU1 | Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | E.coli |
| CSB-EP007763HU | Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | E.coli |
| CSB-EP007763HU3 | Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | E.coli |
| CSB-MP007763HU | Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) | Mammalian cell |
ERBB2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP007763DO CSB-EP007763DO CSB-BP007763DO CSB-MP007763DO CSB-EP007763DO-B |
Recombinant Dog Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERBB2 Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP736718MRG CSB-EP736718MRG CSB-BP736718MRG CSB-MP736718MRG CSB-EP736718MRG-B |
Recombinant Mesocricetus auratus Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERBB2 ELISA Kit
ERBB2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11161h | Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.04 ng/mL |
