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淋巴癌

淋巴癌,也稱(chēng)為淋巴瘤,是一組起源于淋巴結(jié)和其他淋巴組織的惡性腫瘤。根據(jù)病理特性,淋巴瘤可以分為霍奇金病(HD)和非霍奇金淋巴瘤(NHL)兩大類(lèi)?;羝娼鸩∈且环N較為罕見(jiàn)的類(lèi)型,而非霍奇金淋巴瘤則包括多種亞型,如濾泡型、彌漫大B細(xì)胞淋巴瘤等。

淋巴瘤的發(fā)病原因與風(fēng)險(xiǎn)因素多樣,包括遺傳因素、環(huán)境因素、生活方式、飲食習(xí)慣以及某些特定的病毒感染等。如Epstein Barr病毒、人類(lèi)嗜T淋巴細(xì)胞病毒-1等,可以直接感染淋巴細(xì)胞,破壞其正常功能,從而增加淋巴瘤的風(fēng)險(xiǎn)。此外,HIV感染也顯著增加了淋巴瘤的風(fēng)險(xiǎn)。

治療淋巴瘤的方法多樣,包括化療、放療、免疫治療、靶向治療以及造血干細(xì)胞移植等。近年來(lái),隨著醫(yī)學(xué)研究的進(jìn)展,淋巴瘤的治療效果有了顯著提高。自rituximab作為首個(gè)成功的B細(xì)胞非霍奇金淋巴瘤免疫療法以來(lái),免疫治療領(lǐng)域經(jīng)歷了革命性的變化。目前最令人興奮的免疫治療方法包括嵌合抗原受體T細(xì)胞(CAR-T)、雙特異性抗體、免疫檢查點(diǎn)抑制劑和疫苗。特別是針對(duì)PD-1/PD-L1的單抗藥物在初治或復(fù)發(fā)難治性淋巴瘤患者中顯示出顯著的治療效果。自體造血干細(xì)胞移植也是治療淋巴瘤的有效方案之一。其移植前的治療從最初以單純大劑量放化療作為預(yù)處理方案發(fā)展到聯(lián)合利妥昔單抗(靶向CD20)甚至聯(lián)合同位素標(biāo)記的單抗作為預(yù)處理方案;利妥昔單抗也從僅作為預(yù)處理前的凈化用藥發(fā)展到利妥昔單抗在移植前后長(zhǎng)期序貫用藥。

淋巴瘤的治療正在向著更加個(gè)性化、精準(zhǔn)化的方向發(fā)展。華美生物提供淋巴瘤藥物開(kāi)發(fā)靶點(diǎn)蛋白、穩(wěn)定細(xì)胞株、重組抗體、ELISA試劑盒等產(chǎn)品,助力基礎(chǔ)科研及藥物研發(fā)。

淋巴癌藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

MS4A1(CD20)
CSB-MP015007HU
CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL

CSB-MP004900HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP004940HU Activity Verified

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CSB-MP023983HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L (CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml

CSB-MP023997HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9 (CSB-MP023984HU1), the EC50 is 2.671-3.702 ng/mL

CSB-MP011649HU3 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.

產(chǎn)品名稱(chēng) 貨號(hào) 靶點(diǎn) 來(lái)源 蛋白標(biāo)簽
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active) CSB-AP005061HU CD19 Mammalian cell C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active) CSB-MP004900HU CD22 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active) CSB-MP004925HU CD33 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human T-cell antigen CD7 (CD7), partial (Active) CSB-MP004953HU CD7 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active) CSB-MP004954HU1 CD70 Mammalian cell N-terminal 10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active) CSB-AP003581HU CSF2 E.coli Tag-Free
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active) CSB-AP003601HU CSF2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active) CSB-AP003651MO Csf2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active) CSB-AP003661MO Csf2 E.coli Tag-Free
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged

● 穩(wěn)定細(xì)胞株

CSB-SC020067HU FACS

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

FTL Recombinant Monoclonal Antibody
CSB-RA956089A0HU
CSB-RA956089A0HU FC

Overlay Peak curve showing MCF-7 cells stained with CSB-RA956089A0HU (red line) at 1:50.

ICAM1 Recombinant Monoclonal Antibody
CSB-RA162789A0HU
CSB-RA162789A0HU FC

Overlay histogram showing Raji cells surface stained with CSB-RA162789A0HU (red line) at 1:50.

產(chǎn)品名稱(chēng) 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
CD19 Recombinant Monoclonal Antibody CSB-RA004888A0HU CD19 Human ELISA
CD19 Recombinant Monoclonal Antibody CSB-RA780821A0HU CD19 Human ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody CSB-RA004888MA1HU CD19 Human, Mouse ELISA, WB
CD22 Recombinant Monoclonal Antibody CSB-RA962691A0HU CD22 Human ELISA, IHC
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody CSB-RA796695A0HU CD38 Human ELISA, WB, IHC
CD4 Recombinant Monoclonal Antibody CSB-RA004935A0HU CD4 Human ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CD70 Recombinant Monoclonal Antibody CSB-RA004954MA1HU CD70 Human ELISA
CD80 Recombinant Monoclonal Antibody CSB-RA246383A0HU CD80 Human ELISA, WB, IHC, IP
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC

● ELISA試劑盒

產(chǎn)品名稱(chēng) 貨號(hào) 靶點(diǎn) 檢測(cè)范圍 靈敏度
Human Natural killer cell receptor 2B4(CD244) ELISA kit CSB-EL004903HU CD244 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human soluble cluster of differentiation 28,sCD28 ELISA Kit CSB-E09296h CD28 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human Myeloid cell surface antigen CD33(CD33) ELISA kit CSB-EL004925HU CD33 125 pg/mL-8000 pg/mL 31.25 pg/mL
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit CSB-E09884h CD38 0.9 ng/mL-60 ng/mL 0.225 ng/mL
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit CSB-EL004929MO CD38 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human cluster of differentiation 4,CD4 ELISA Kit CSB-E08956h CD4 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Rat cluster of differentiation 4,CD4 ELISA Kit CSB-E12928r CD4 0.78 U/mL-50 U/mL 0.195 U/mL
Chicken Cluster of Differentiation 4(CD4) ELISA Kit CSB-E13114C CD4 3.125 ng/mL-800 ng/mL 3.125 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human CAMPATH-1 antigen(CD52) ELISA kit CSB-EL004943HU CD52 78 ng/mL-5000 ng/mL 19.5 ng/mL
Mouse cluster of differentiation 6(CD6) ELISA Kit CSB-EL004949MO CD6 Request Information Request Information
Human CD70 antigen(CD70) ELISA kit CSB-EL004954HU CD70 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Mouse CD70 antigen(CD70) ELISA kit CSB-EL004954MO CD70 Request Information Request Information
Mouse T-lymphocyte activation antigen CD80(CD80) ELISA kit CSB-EL004959MO CD80 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human Soluble Cluster of Differentiation 80 (sCD80) ELISA Kit CSB-E15768h CD80 125 pg/mL-8000 pg/mL 31.25 pg/mL