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食管癌

食管癌是一種起源于食管上皮細(xì)胞的惡性腫瘤,其發(fā)病率和死亡率在全球范圍內(nèi)較高。食管癌的兩種主要類型是鱗狀細(xì)胞癌和腺癌,其中鱗狀細(xì)胞癌在亞洲較為常見,而腺癌在西方國(guó)家較為普遍。食管癌的病因可能包括吸煙、飲酒、長(zhǎng)期胃食管反流病、巴雷特食管以及某些遺傳因素等。

食管癌的治療取決于癌癥的分期、位置和患者的整體健康狀況。早期食管癌可能通過(guò)內(nèi)鏡下治療(如內(nèi)鏡黏膜切除術(shù)或內(nèi)鏡下黏膜剝離術(shù))來(lái)治療。對(duì)于更晚期的食管癌,常用的治療方法包括手術(shù)切除、化療、放療或這些方法的組合。

近年來(lái),食管癌的藥物研發(fā)取得了顯著進(jìn)展。免疫治療已經(jīng)成為晚期食管癌治療的新標(biāo)準(zhǔn),特別是對(duì)于一線化療失敗的患者。免疫檢查點(diǎn)抑制劑,如帕博利珠單抗(Pembrolizumab)、納武利尤單抗(Nivolumab)和卡瑞利珠單抗(Camrelizumab),已經(jīng)在臨床試驗(yàn)中顯示出對(duì)食管癌患者的潛在療效。此外,針對(duì)HER2陽(yáng)性的食管胃交界部腺癌,曲妥珠單抗(Trastuzumab)的使用也顯示出一定的療效。

在靶向治療方面,針對(duì)腫瘤生長(zhǎng)和血管生成的特定分子靶點(diǎn)的藥物也在不斷研發(fā)中。例如,針對(duì)VEGFR、EGFR和HER2的小分子酪氨酸激酶抑制劑,如阿法替尼(Afatinib)和雷格拉替尼(Regorafenib),已經(jīng)在食管癌治療中顯示出一定的療效。

食管癌藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP005498HU(A5) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml.

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP006163HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP675446HU Activity Verified

FACS assay shows that Human TIGIT can bind to 293F cell overexpressing human CD155

CSB-MP007765HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized NRG1 (CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC50 is 12.32-15.74 ng/ml.

CSB-MP013714HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized MET at 2 μg/ml can bind Anti-MET recombinant antibody, the EC50 is 2.379-3.094 ng/ml.

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 來(lái)源 蛋白標(biāo)簽
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Macaca fascicularis Claudin (CLDN18)-VLPs (Active) CSB-MP4304MOV CLDN18 Mammalian cell N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Mouse Claudin-18 (Cldn18)-VLPs (Active) CSB-MP005498MO(F3) Cldn18 Mammalian cell N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) CSB-MP007765HU ERBB3 Mammalian cell C-terminal hFc-tagged
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) CSB-MP010053HU GUCY2C Mammalian cell N-terminal 10xHis-tagged
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) CSB-MP010053HUd9 GUCY2C Mammalian cell C-terminal hFc-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active) CSB-AP005281HU HAVCR2 Mammalian cell C-terminal FC-Avi-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active) CSB-AP005291HU HAVCR2 Mammalian cell C-terminal 6xHis-Fc-tagged
Recombinant Mouse Hepatitis A virus cellular receptor 2 homolog (Havcr2), partial (Active) CSB-AP005341MO Havcr2 Mammalian cell C-terminal Fc-tagged

● 重組抗體

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU
CSB-RA004936MA1HU FC

Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

Claudin-18.2 Recombinant Monoclonal Antibody
CSB-RA005498A1HU
CSB-RA005498A1HU FC

Untransfected KATO3 cells surface (green line), transfected Human CLDN18.2 KATO3 stable cells surface (red line) and transfected.

GUCY2C Recombinant Monoclonal Antibody
CSB-RA010053A3HU
CSB-RA010053A3HU FC

T84 cells were stained with Human IgG (green line) and anti-GUCY2C antibody (red line) (2μg/1*106 cells),

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CLDN18 Recombinant Monoclonal Antibody CSB-RA005498A2HU CLDN18 Human ELISA, FC
Claudin-18.2 Recombinant Monoclonal Antibody CSB-RA005498A1HU CLDN18 Human ELISA, FC
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody CSB-RA260392A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU ERBB2 Human ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody CSB-RA588766A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA2HU ERBB2 Human ELISA, IHC
ERBB3 Recombinant Monoclonal Antibody CSB-RA937008A0HU ERBB3 Human ELISA, IF
GUCY2C Recombinant Monoclonal Antibody CSB-RA010053A3HU GUCY2C Human ELISA, FC
GUCY2C Recombinant Monoclonal Antibody CSB-RA010053A2HU GUCY2C Human ELISA, FC
IL2RA Recombinant Monoclonal Antibody CSB-RA011649MA1HU IL2RA Human ELISA, IF
MET Recombinant Monoclonal Antibody CSB-RA983271A0HU MET Human ELISA, WB, IHC, IF, FC
MET Recombinant Monoclonal Antibody CSB-RA634199A0HU MET Human ELISA, IHC
MET Recombinant Monoclonal Antibody CSB-RA013714MA1HU MET Human ELISA, IF, FC
MUC17 Recombinant Monoclonal Antibody CSB-RA727848MA1HU MUC17 Human ELISA
NECTIN4 Recombinant Monoclonal Antibody CSB-RA822274A0HU NECTIN4 Human ELISA
PDCD1 Recombinant Monoclonal Antibody CSB-RA240597A0HU PDCD1 Human ELISA, WB, IHC
TOP1 Recombinant Monoclonal Antibody CSB-RA792129A0HU TOP1 Human ELISA, WB, IHC, FC, IP

● ELISA試劑盒

產(chǎn)品名稱 貨號(hào) 靶點(diǎn) 檢測(cè)范圍 靈敏度
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit CSB-E11161h ERBB2 0.156 ng/mL-10 ng/mL 0.04 ng/mL
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit CSB-EL007765HU ERBB3 125 pg/mL-8000 pg/mL 31.25 pg/mL
Human Hepatitis A virus cellular receptor 2(HAVCR2) ELISA kit CSB-EL010145HU HAVCR2 47 pg/mL-3000 pg/mL 11.75 pg/mL
Bovine Interleukin 12,IL-12 ELISA Kit CSB-E14010B IL12A 6.25 pg/mL-400 pg/mL 1.56 pg/mL
Human Interleukin 15,IL-15 ELISA KIT CSB-E04603h IL15 3.12 pg/ml - 200 pg/ml 0.78 pg/ml
Mouse Interleukin 15,IL-15 ELISA Kit CSB-E04604m IL15 0.3125 - 20ng/ml 0.078 ng/ml
Rat Interleukin 15,IL-15 ELISA KIT CSB-E07453r IL15 1.56 pg/mL-100 pg/mL 0.39 pg/mL
Pig Interleukin 15(IL-15) ELISA Kit CSB-E14320p IL15 0.78 pg/mL-50 pg/mL 0.195 pg/mL
Monkey Interleukin 15,IL-15 ELISA Kit CSB-E14392Mk IL15 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human soluble interleukin-2 receptor,IL-2sRα ELISA kit CSB-E04629h IL2RA 78 pg/mL-5000 pg/mL 19.5 pg/mL
Mouse soluble interleukin-2 receptor,sIL-2Rα ELISA kit CSB-E07440m IL2RA 15.6 pg/ml - 1000 pg/ml 3.9 pg/ml