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TP53

TP53,即腫瘤蛋白p53,別名CC7、Cellular tumor antigen p53、LFS1、Mutant tumor protein 53、p53。它是一種由TP53基因編碼的轉(zhuǎn)錄因子,位于人類第17號染色體上,是細胞周期的關(guān)鍵調(diào)控因子。TP53的作用機制主要是通過響應(yīng)細胞應(yīng)激反應(yīng),如DNA損傷、缺氧、代謝應(yīng)激等,調(diào)節(jié)多種下游基因的表達,從而誘導(dǎo)細胞周期停滯、凋亡、衰老、DNA修復(fù)或代謝變化。TP53參與了細胞周期的調(diào)控、DNA損傷修復(fù)、細胞凋亡和衰老等過程,被廣泛認為是“基因組的衛(wèi)士”。TP53的突變與多種人類癌癥的發(fā)生發(fā)展有關(guān),包括遺傳性癌癥如Li-Fraumeni綜合征。此外,TP53還調(diào)節(jié)細胞代謝、鐵死亡、腫瘤微環(huán)境、自噬等,這些都有助于腫瘤抑制。TP53的突變不僅損害其抑癌功能,而且還可能賦予p53突變體致癌特性,使其成為開發(fā)新抗癌藥物的一個非常有吸引力的靶點 。

熱銷產(chǎn)品

Recombinant Human Cellular tumor antigen p53 (TP53) (CSB-BP024077HU)

驗證數(shù)據(jù)

CSB-BP024077HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TP53 Recombinant Monoclonal Antibody (CSB-RA236796A0HU)

驗證數(shù)據(jù)

CSB-RA236796A0HU

Western Blot
Positive WB detected in: COLO320 whole cell lysate, 293 whole cell lysate
All lanes: TP53 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 44, 38, 39, 40, 34, 35, 30, 24, 25 kDa
Observed band size: 53 kDa

CSB-RA236796A0HU

IHC image of CSB-RA236796A0HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA236796A0HU

Immunofluorescence staining of HepG2 Cells with CSB-RA236796A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

Human p53/tumor protein,p53/TP53 ELISA Kit (CSB-E08334h)

驗證數(shù)據(jù)

CSB-E08334h 標(biāo)準(zhǔn)曲線

貨號:CSB-E08334h

規(guī)格:96T/48T

靈敏度:2.34 pg/mL

檢測范圍:9.38 pg/mL-600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

TP53 Antibodies

TP53 for Rattus norvegicus (Rat)

TP53 for Homo sapiens (Human)

TP53 for Mus musculus (Mouse)

TP53 for H

TP53 for H,R,M

TP53 Proteins

TP53 Proteins for Equus caballus (Horse)

TP53 Proteins for Bos taurus (Bovine)

TP53 Proteins for Gallus gallus (Chicken)

TP53 Proteins for Felis catus (Cat) (Felis silvestris catus)

TP53 Proteins for Ovis aries (Sheep)

TP53 Proteins for Macaca mulatta (Rhesus macaque)

TP53 Proteins for Homo sapiens (Human)

TP53 Proteins for Mus musculus (Mouse)

TP53 Proteins for Bos indicus (Zebu)

TP53 Proteins for Oryzias latipes (Medaka fish) (Japanese ricefish)

TP53 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

TP53 Proteins for Rattus norvegicus (Rat)

TP53 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

TP53 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

TP53 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

TP53 Proteins for Macaca fuscata fuscata (Japanese macaque)

TP53 Proteins for Xenopus laevis (African clawed frog)

TP53 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

TP53 Proteins for Platichthys flesus (European flounder) (Pleuronectes flesus)

TP53 Proteins for Marmota monax (Woodchuck)

TP53 Proteins for Xiphophorus helleri (Green swordtail)

TP53 Proteins for Ictalurus punctatus (Channel catfish)

TP53 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

TP53 Proteins for Equus asinus (Donkey)

TP53 Proteins for Spermophilus beecheyi (Beechey ground squirrel) (Otospermophilus beecheyi)

TP53 Proteins for Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)

TP53 Proteins for Delphinapterus leucas (Beluga whale)

TP53 Proteins for Oryctolagus cuniculus (Rabbit)

TP53 Proteins for Tupaia belangeri (Common tree shrew) (Tupaia glis belangeri)

TP53 Proteins for Sus scrofa (Pig)

TP53 Proteins for Cavia porcellus (Guinea pig)

TP53 Proteins for Barbus barbus (Barbel)

TP53 Proteins for Tetraodon miurus (Congo puffer)

TP53 ELISA Kit

TP53 ELISA Kit for Homo sapiens (Human)