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TF

轉(zhuǎn)鐵蛋白(Transferrin,TF)是一種重要的β-球蛋白,主要承擔(dān)在血漿中結(jié)合并轉(zhuǎn)運(yùn)鐵離子的職責(zé)。其結(jié)構(gòu)為單鏈糖蛋白,分子量約為7.7萬(wàn),含糖量約6%,具備可逆地結(jié)合多價(jià)離子的特性,特別是鐵離子,每分子能結(jié)合兩個(gè)三價(jià)鐵原子,從而有效實(shí)現(xiàn)鐵離子在體內(nèi)的轉(zhuǎn)運(yùn)。功能上,轉(zhuǎn)鐵蛋白不僅以TRF-Fe3+的復(fù)合物形式將鐵輸送至骨髓供成熟紅細(xì)胞生成,還可在鐵過(guò)剩時(shí)與鐵離子結(jié)合形成穩(wěn)定復(fù)合物,防止鐵毒性積累和氧化損傷。此外,它參與調(diào)節(jié)體內(nèi)鐵離子的平衡,確保細(xì)胞和組織對(duì)鐵的需求得到滿足,從而維持鐵穩(wěn)態(tài)。值得一提的是,轉(zhuǎn)鐵蛋白通過(guò)與轉(zhuǎn)鐵蛋白受體(TfR)結(jié)合,可能激活涉及細(xì)胞增殖、分化、凋亡及免疫反應(yīng)的信號(hào)通路,為腫瘤細(xì)胞診療提供了新的靶向介質(zhì)。然而,轉(zhuǎn)鐵蛋白信號(hào)通路的詳細(xì)機(jī)制仍需深入研究以全面理解其在生物體中的作用。

熱銷產(chǎn)品

Recombinant Human Tissue factor (F3), partial

驗(yàn)證數(shù)據(jù)

SDS
CSB-MP007125HU SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LCMS
CSB-MP007125HU LCMS-1

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP007928HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) F3.

LCMS
CSB-MP007125HU LCMS-2

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP007928HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) F3.


TF Antibodies

TF for Homo sapiens (Human)

TF for Rattus norvegicus (Rat)

TF for H

TF for Mus musculus (Mouse)

TF Proteins

TF Proteins for Homo sapiens (Human)

TF Proteins for Oryctolagus cuniculus (Rabbit)

TF Proteins for Equus caballus (Horse)

TF Proteins for Sus scrofa (Pig)

TF Proteins for Oryzias latipes (Medaka fish) (Japanese ricefish)

TF Proteins for Oncorhynchus kisutch (Coho salmon)

TF Proteins for Rattus norvegicus (Rat)

TF Proteins for Pan troglodytes (Chimpanzee)

TF Proteins for Paralichthys olivaceus (Japanese flounder) (Hippoglossus olivaceus)

TF Proteins for Bos taurus (Bovine)

TF Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

TF Proteins for Gadus morhua (Atlantic cod)

TF Proteins for Mus musculus (Mouse)

TF ELISA Kit

TF ELISA Kit for Homo sapiens (Human)

TF ELISA Kit for Mus musculus (Mouse)

TF ELISA Kit for Sus scrofa (Pig)

TF ELISA Kit for Rattus norvegicus (Rat)