CCR8
CCR8:Tregs細胞的特異性靶點,催生下一代重磅腫瘤免疫藥物!
CCR8在腫瘤浸潤的調節(jié)性T細胞(Treg)上特異性表達,在輔助型T細胞2(Th2)和腫瘤細胞也均有表達;然而在外周血Treg或正常組織上基本不表達。CCR8的主要作用是參與Tregs和Th2細胞向炎癥和腫瘤部位的募集。Tregs增強了腫瘤細胞的浸潤能力,通過抑制攻擊腫瘤的免疫細胞的免疫反應,從而使腫瘤細胞發(fā)生免疫逃逸。研究發(fā)現(xiàn),與正常組織中的Tregs相比,CCR8在人類乳腺癌的腫瘤浸潤性Tregs中顯著上調,表明CCR8是TME中Tregs上的一個有希望的治療靶點,而不會引起系統(tǒng)性自身免疫。因此,以CCR8為靶點的抗體,清除腫瘤微環(huán)境中的Treg細胞,將改善TME的免疫功能。
CUSABIO-哺乳包膜VLPs平臺成功開發(fā)CCR8全長膜蛋白(7次跨膜),展示了完整生物活性。
Recombinant Human CCR8-VLPs 活性蛋白實驗驗證數(shù)據(jù)
● 經WB驗證蛋白特異性
CSB-MP004847HU is detected by Mouse anti-6*His monoclonal antibody.
CSB-MP004847HU is detected by Anti-CCR8 recombinant Antibody
● 功能性ELISA驗證高活性
Immobilized human CCR8 at 5 μg/ml can bind Anti-CCR8 recombinant Antibody. The EC50 is 11.13-17.29 ng/mL.
● 經TEM驗證蛋白正確組裝
The VLP-like structures of CCR8 has been confirmed by TEM.
CCR8 Antibodies
CCR8 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA091770 | CCR8 Antibody | Human | ELISA,WB,IHC |
CSB-PA172806 | CCR8 Antibody | Human | ELISA,WB,IHC |
CSB-RA004847A1HU | CCR8 Recombinant Monoclonal Antibody | Human | FC |
CSB-RA004847MA2HU | CCR8 Recombinant Monoclonal Antibody | Human | FC |
CSB-RA004847MA3HU | CCR8 Recombinant Monoclonal Antibody | Human | ELISA, FC |
CCR8 Proteins
CCR8 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-EP004847HU1 CSB-BP004847HU1 CSB-MP004847HU1 CSB-EP004847HU1-B |
Recombinant Human C-C chemokine receptor type 8 (CCR8), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF004847HU | Recombinant Human C-C chemokine receptor type 8 (CCR8) | in vitro E.coli expression system |
CSB-CF004847HU2 | Recombinant Human C-C chemokine receptor type 8 (CCR8), partial | in vitro E.coli expression system |
CSB-CF004847HU2-N | Recombinant Human C-C chemokine receptor type 8 (CCR8), partial,Nanodiscs | in vitro E.coli expression system |
CSB-YP004847HU1 | Recombinant Human C-C chemokine receptor type 8 (CCR8), partial | Yeast |
CSB-MP004847HU | Recombinant Human C-C chemokine receptor type 8 (CCR8)-VLPs (Active) | Mammalian cell |
CCR8 Proteins for Mus musculus (Mouse)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP004847MO1 CSB-EP004847MO1 CSB-BP004847MO1 CSB-MP004847MO1 CSB-EP004847MO1-B |
Recombinant Mouse C-C chemokine receptor type 8 (Ccr8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF004847MO | Recombinant Mouse C-C chemokine receptor type 8 (Ccr8) | in vitro E.coli expression system |
CSB-MP004847MO | Recombinant Mouse C-C chemokine receptor type 8 (Ccr8)-VLPs | Mammalian cell |
CCR8 Proteins for Macaca mulatta (Rhesus macaque)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP004847MOW1 CSB-EP004847MOW1 CSB-BP004847MOW1 CSB-MP004847MOW1 CSB-EP004847MOW1-B |
Recombinant Macaca mulatta C-C chemokine receptor type 8 (CCR8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF004847MOW | Recombinant Macaca mulatta C-C chemokine receptor type 8 (CCR8) | in vitro E.coli expression system |