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DLL3

DLL3(Delta-like protein 3),也被稱為Delta樣蛋白3,是一種在細胞信號傳導中起作用的跨膜蛋白,它是Notch信號通路的成員之一,對于細胞分化和發(fā)育至關重要。LL3參與細胞間通訊,是Notch受體的配體之一。它與相鄰細胞上的Notch受體相互作用,觸發(fā)一個信號級聯(lián),可以影響細胞命運決策,包括細胞分化和增殖。DLL3在胚胎發(fā)育中尤其重要,特別是在神經系統(tǒng)的發(fā)育過程中。在小細胞肺癌(SCLC)中,DLL3通常被過度表達,這種過度表達被認為是一個潛在的治療靶點。已經開發(fā)了幾種實驗性治療方法,如抗體藥物結合物(ADCs),以靶向SCLC細胞中的DLL3。了解DLL3在癌癥細胞中的功能,有望推動對某些類型癌癥更有針對性和有效的治療方法的開發(fā),為患者提供改善預后的希望。

更多相關閱讀:DLL3:肺癌“網(wǎng)紅”靶點,或成精準治療新希望

熱銷產品

Recombinant Human Delta-like protein 3(DLL3),partial (Active) CSB-MP882142HU

驗證數(shù)據(jù)

SDS
CSB-MP882142HU SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
High Purity Validated of CSB-MP882142HU

Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 at 2 μg/ml can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL.

Recombinant Macaca fascicularis Delta-like protein 3(DLL3),partial (Active) CSB-MP3536MOV

驗證數(shù)據(jù)

SDS
CSB-MP3536MOV SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
High Purity Validated of CSB-MP3536MOV

Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 at 2 μg/ml can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.625-2.702 ng/mL.

DLL3 Recombinant Monoclonal Antibody CSB-RA882142A1HU

驗證數(shù)據(jù)

FC
CSB-RA882142A1HU FC

Untransfected HEK293 cells (green line) and transfected Human DLL3 HEK293 stable cells (red line) were stained with anti-DLL3 antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.

ELISA
High Purity Validated of CSB-RA882142A1HU

The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP3536MOV) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody (CSB-RA882142A1HU), the EC50 is 1.625-2.702 ng/mL.

ELISA
High Purity Validated of CSB-RA882142A1HU

The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP882142HU) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody (CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL.

DLL3 Antibodies

DLL3 for Homo sapiens (Human)

DLL3 Proteins

DLL3 Proteins for Mus musculus (Mouse)

DLL3 Proteins for Rattus norvegicus (Rat)

DLL3 Proteins for Xenopus laevis (African clawed frog)

DLL3 Proteins for Homo sapiens (Human)

DLL3 ELISA Kit

DLL3 ELISA Kit for Homo sapiens (Human)