Mouse Delta-like protein 4(DLL4) ELISA kit

Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.

1. anti-Dll4 antibody could inhibit the differentiation of Th17 cells in asthmatic mice. PMID: 28812183
2. Data suggest that endothelial specific Delta-like 4 (Dll4) overexpression appears as a promising anti-angiogenic modality that might improve cancer control. PMID: 28288569
3. Dll4 seems to promote Apc (Min/+) tumorigenesis. PMID: 28086833
4. Dll4-Notch1 signalling couples sprouting angiogenesis and artery formation. PMID: 28714968
5. Results suggest that Dll4 activation during differentiation sustained Treg cell phenotype and function to control respiratory syncytial virus infection. PMID: 28077598
6. DLL4 expression is not associated with the Pathogenesis of Non-Alcoholic Steatohepatitis. PMID: 27898698
7. Dll4 modulates liver inflammatory response by down-regulating chemokine expression PMID: 27171900
8. Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling PMID: 26870802
9. miRNA-30e targeted the 3'-UTR of Dll4 and downregulated Dll4 expression PMID: 26786283
10. Dll4/Notch signaling and HIF-1alpha are closely related to lymphangiogenesis in dry eye-induced lacrimal glands. PMID: 26828208
11. Dll4-induced Notch1 activity is required to specify the arterial programme in the aorta-gonad-mesonephros embryonic region. PMID: 26465397
12. Tumor promoting effect of low-dosage inhibition needs to be considered when implementing Delta-like 4 targeting therapies. PMID: 26314892
13. The heart defects in Dll4-/- embryos are consistent with primary defects in vessel patterning. PMID: 26340748
14. DLL4 is an efficient cis-inhibitor of Notch signaling during embryogenesis. PMID: 26114479
15. Macrophage Dll4 promotes lesion development in vein grafts via macrophage activation and crosstalk between macrophages and smooth muscle cells. PMID: 26404485
16. work reveals how lymphatic vessel responses are shaped by tissue specialization and uncover a role for continuous DLL4 signaling in the function of adult lymphatic vasculature. PMID: 26529256
17. Delta-like 4-mediated Notch signaling is required for early T-cell development in a three-dimensional thymic structure. PMID: 25976373
18. a reduction of mechanical force near the boundary promotes Notch1-Dll4 signalling to dynamically regulate the density of leader cells during collective cell migration PMID: 25766473
19. selective expression of Dll4 in progenitors/precursors contributes to its functional specificity in neuronal specification and that the Dll4-Cre line is a valuable tool for gene manipulation to study Notch signaling. PMID: 25179941
20. The Notch ligand DLL4 is abundantly expressed on bone marrow Ocn(+) cells, and selective depletion of DLL4 from these cells recapitulated the thymopoietic abnormality PMID: 25918341
21. CCM1- and CCM3-silenced endothelial cells have a reduced expression of the Notch ligand Delta-like 4 (DLL4) resulting in impaired Notch signaling PMID: 25791711
22. Data indicate that systemic delta-like 1 protein Dll1/delta-like4 protein Dll4 inhibition decreased T cell cytokines and graft infiltration. PMID: 25687759
23. Dll4 plays a key role in regulating decidual angiogenesis and related pregnancy through induction of a tip/stalk phenotype. PMID: 24780197
24. Data show that one mechanism by which sex steroids influence thymopoiesis is through direct inhibition in cortical thymic epithelial cells (cTECs) of Delta-like 4 (Dll4), a Notch ligand crucial for the commitment and differentiation of T cell progenitors. PMID: 25332287
25. study demonstrates activity-dependent reduction of DLL4 expression and proteolytic cleavage of Notch3 in the hypothalamic-neurohypophysial system. PMID: 24943269
26. Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells. PMID: 24386421
27. Demonstrate that the action of IFNgamma on endothelial cellss, but not other cells, is highly effective for tumour angiostasis, which involves down-regulating Dll4. PMID: 24615277
28. Dll4/Notch signaling in tumor cells magnified TGF-beta-induced pSMAD2/3 signaling and was required to sustain TGF-beta-induced tumor cell growth PMID: 24520074
29. The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated in the mouse testis PMID: 24015274
30. We provide evidence that BMP/TGFbeta signaling is activated in V2b precursors and that Dll4-mediated Notch signaling is responsible for this activation. PMID: 24257627
31. DL4-mediated Notch signaling is essential for the development of both alphabeta and gammadelta T-cell lineages in the embryo. PMID: 23881845
32. The Dll4/Notch-1 signaling pathway has a modulatory role in VEGF-dependent luteal angiogenesis and related function through induction of a tip/stalk phenotype. PMID: 24074756
33. Hypoxia upregulates expression of the Notch ligand Dll4 and increases Notch signaling in a process requiring the vasoactive hormone adrenomedullin. PMID: 23379656
34. Overexpression of miR-126 results in the upregulation of VEGF, bFGF and Notch ligand Dll4 in the mesenchymal stem cells. PMID: 23229021
35. Data indicate that expression of Dll4 is specific to theca layer endothelial cells (ECs); Notch1/Notch4 in theca layer ECs and vascular smooth muscle cells (VSMCs), Notch3 is restricted to VSMCs; Notch2 in granulosa cells (GCs) of small follicles. PMID: 23675950
36. Vegf signaling activates MAP kinase (MAPK)-dependent E26 transformation-specific sequence factors in the arterial endothelium to drive expression of Dll4 and Notch4. PMID: 23830865
37. Arterial Dll4 expression requires the direct binding of both the RBPJ/Notch intracellular domain and SOXF transcription factors. PMID: 23818617
38. expression induced by VEGF-A in adult endothelial cells PMID: 23394931
39. The present study focused on the effects of systemic anti-Dll4 targeting in the bone marrow (BM) microenvironment. PMID: 23285048
40. Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. PMID: 23533173
41. endothelium, via Dll4 and PDGF-BB, induces a fate switch in adjacent skeletal myoblasts PMID: 23477786
42. sDLL4/28-525 inhibited CNV in C57Bl6 and its effect was reversed by a gamma-secretase inhibitor that blocks Notch signaling PMID: 22869002
43. Data show that Notch1/Dll4-mediated T-cell instructive signals to long-term HSCs (LT-HSCs) are suppressed by Lrf expression in the bone marrow microenvironment. PMID: 23134786
44. delta-like 4 (Dll4) function relies on a combination of factors, which include strong Mindbomb1 (Mib1) association ubiquitination, and internalization and recycling back to the cell surface, to engage Notch1 effectively. PMID: 23162128
45. Dll4 skewed macrophages toward a proinflammatory phenotype ("M1"). These results suggest that Dll4-Notch signaling plays a central role in the shared mechanism for the pathogenesis of cardiometabolic disorders. PMID: 22699504
46. This study highlights a role for Dll4 in the quantitative regulation of early hemato-vascular precursors, further indicating that it is also involved on the timely emergence of mesoderm in early embryogenesis. PMID: 22514637
47. Anti-Dll4 treatment reverses established type 1 diabetes (T1D)and fully prevents T1D via a T(reg) cell-mediated mechanism and inhibits CD8(+) T cell pancreatic islet infiltration. PMID: 22547652
48. Data show that that inhibition of Dll4/Notch signaling causes improved vascular function and accelerated wound healing. PMID: 22279550
49. The findings provide in vivo evidence for a regulatory loop between BMP/TGFbeta-Smad1/5 and Notch/dll4 signaling that orchestrates tip- versus stalk-cell selection and vessel plasticity in angiogenesis. PMID: 22364862
50. Dll4 is directly activated by Foxn4 via phylogenetically conserved enhancers. Dll4 can partly mediate the Foxn4 function by serving as a major Notch ligand to expand the progenitor pool and limit photoreceptor production. PMID: 22323600

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Cell membrane; Single-pass type I membrane protein.

Expressed in vascular endothelium. Expressed in retina at least during embryogenesis.

KEGG: mmu:54485

STRING: 10090.ENSMUSP00000099575

UniGene: Mm.143719