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  4. Rat Angiopoietin 2,ANG-2 ELISA Kit

Rat Angiopoietin 2,ANG-2 ELISA Kit

  • 中文名稱：
    大鼠血管生成素2(ANG-2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E07304r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3900/￥2500
  • 其他：

產(chǎn)品詳情

  • 別名：
    Angpt2 ELISA Kit; Agpt2Angiopoietin-2 ELISA Kit; ANG-2 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates.
  • 檢測(cè)范圍：
    0.02 ng/ml-50 ng/ml.
  • 靈敏度：
    0.02 ng/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
  • 基因功能參考文獻(xiàn)：
    1. Based on these findings, we propose that Cx43 was the Cx isoform involved in MEGJ-mediated VEC-dependent regulation of Ang-2, which induces iNOS protein expression and vascular hyporeactivity after hypoxia. PMID: 28637680
    2. H2S may play a protective role in infrarenal aortic clamping induced acute lung injury in rats by inhibiting inflammation and Ang2 release. PMID: 26781077
    3. Inhibition of angiopoietin-2 is an effective and safe treatment for liver fibrosis in CCl4 -treated rats, acting mainly through the induction of vessel normalization and the attenuation of hepatic inflammatory infiltrate. PMID: 24612347
    4. responsible for the vascular hyporeactivity at late hemorrhagic shock through the Tie2-Erk-iNOS pathway PMID: 22869617
    5. it is unlikely that induction of Ang-2 contributes to vascular dysfunction underlying functional impairment after spinal cord injury, but rather that it contributes to the beneficial pro-angiogenic and/or gliogenic processes PMID: 22020092
    6. Decreased angiopoietin1/Tie2 and increased angiopoietin2 expression may contribute to diabetes-induced vascular damage after stroke. PMID: 21515377
    7. Hyperoxia induced neovascularization and inhibited the expression of ang-2 in the retina. PMID: 19573435
    8. The expression of Ang-2 protein in serum was significantly positively correlated with the extent lung injury. PMID: 19900368
    9. Expression of angiopoietin-2 increased after stroke in all rat strains and was significantly enhanced in SHR stroke-prone compared with control strains PMID: 11822892
    10. These data suggest that Ang2 might modulate both angiogenesis and vascular regression in the rat brain and that capillary regression occurring during deadaptation involves activation of apoptosis. PMID: 12183511
    11. Expressed in rat brain during hypoxia and de-adaptation. PMID: 12580449
    12. we demonstrate that testicular vascular endothelial growth factor-A (VEGF-A), ang 1, ang 2, and the ang-receptor tie 2 are expressed in the testis PMID: 12773423
    13. Angiopoietin2 and Tie2, but not angiopoietin1 mRNA were increased with retinopathy of prematurity. PMID: 12937129
    14. Angiopoietin-1 but not angiopoietin-2 has a role in experimental glioma angiogenesis PMID: 15509526
    15. Following injury, Ang2 may play a role in BBB breakdown of perilesional vessels, and it may also be a factor in endothelial cell apoptosis that occurs at days 1 and 2 following the injury. PMID: 16056241
    16. Data demonstrate that vascular smooth muscle cells adjust angiopoietin-2 expression through multiple mechanisms, including changes in transcription as well as posttranscriptional mRNA destabilization. PMID: 16176970
    17. Up-regulation of Ang-2, a proangiogenic factor, and the down-regulation of PEDF, an antiangiogenic factor, is indicative of an imbalance between pro- and antiangiogenic factors in the hypoxic retina that may favor neovascularization. PMID: 17943991
    18. glomerular expression of ANG-1 and ANG-2 is differentially regulated and may contribute to healing and endothelial cell stabilization in experimental glomerulonephritis PMID: 18272601
    19. Abnormal expression and reciprocal egulation of Angpt2 may play important roles in the development of chronic allograft nephropathy in rat renal allografts. PMID: 18929864
    20. Ang2-derived tumor vessels lead to an inadequate oxygenation of the tumor tissue, leading to impairment in tumor growth PMID: 19168695

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  • 亞細(xì)胞定位：
    Secreted.
  • 數(shù)據(jù)庫(kù)鏈接：