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神經(jīng)科學(xué)研究

重組蛋白
抗體
ELISA試劑盒
神經(jīng)細(xì)胞培養(yǎng)用細(xì)胞因子
神經(jīng)科學(xué)研究

神經(jīng)科學(xué)研究對于理解人類大腦功能、治療神經(jīng)系統(tǒng)疾病以及推動(dòng)相關(guān)藥物開發(fā)具有重要意義。神經(jīng)系統(tǒng)疾病是指影響大腦、脊髓、周圍神經(jīng)以及其他神經(jīng)系統(tǒng)組成部分的疾病。這些疾病包括但不限于腦血管疾病、帕金森病、阿爾茨海默病、多發(fā)性硬化癥、癲癇等。

華美生物提供神經(jīng)科學(xué)研究相關(guān)的蛋白、抗體、ELISA試劑盒產(chǎn)品，以及神經(jīng)細(xì)胞培養(yǎng)常用細(xì)胞因子，助力相關(guān)機(jī)制功能研究及藥物研發(fā)。

神經(jīng)系統(tǒng)疾病及熱門研究靶點(diǎn)

阿爾茨海默病/Alzheimer's Disease (AD)

阿爾茨海默病是一種慢性、進(jìn)展性的神經(jīng)退行性疾病，主要表現(xiàn)為記憶力減退、認(rèn)知功能障礙以及行為和心理癥狀。它是癡呆癥最常見的類型，被認(rèn)為是由于大腦中淀粉樣蛋白斑塊的異常堆積，造成神經(jīng)元大量死亡，以及Tau蛋白異常磷酸化等原因引起。目前，AD的藥物研究靶點(diǎn)主要集中在Aβ、Tau蛋白、BACE1等，同時(shí)也在探索其他潛在靶點(diǎn)，如α-突觸核蛋白、RAGE抑制劑等。

帕金森病/Parkinson's Disease (PD)

帕金森病是一種主要影響運(yùn)動(dòng)功能的神經(jīng)退行性疾病，其特征性癥狀包括靜止性震顫、肌肉僵硬、運(yùn)動(dòng)遲緩以及平衡障礙。帕金森病的發(fā)病機(jī)制復(fù)雜，涉及多種因素，包括多巴胺神經(jīng)元的喪失、蛋白質(zhì)錯(cuò)誤折疊和聚集、線粒體功能障礙、神經(jīng)炎癥、氧化應(yīng)激等。目前，帕金森病的藥物研究靶點(diǎn)主要集中在α-突觸核蛋白聚集、LRRK2基因突變、PAAN/MIF核酸酶活性、線粒體功能失常、自噬機(jī)制以及基于單細(xì)胞測序技術(shù)發(fā)現(xiàn)的特定多巴胺能神經(jīng)元亞群等方面。

肌萎縮側(cè)索硬化癥/Amyotrophic Lateral Sclerosis (ALS)

肌萎縮側(cè)索硬化癥，又稱為漸凍癥，是一種致命的神經(jīng)退行性疾病，主要表現(xiàn)為大腦和脊髓中的運(yùn)動(dòng)神經(jīng)元逐漸喪失，導(dǎo)致肌肉逐漸無力并萎縮，最終影響運(yùn)動(dòng)、交流、吞咽和呼吸功能，最終致死。目前，其研究靶點(diǎn)主要集中在SOD1、C9ORF72、TDP-43、FUS、OPTN、TBK1和RIPK1等基因和蛋白，以及探索利用反義寡核苷酸（ASOs）、干細(xì)胞與基因工程相結(jié)合的新療法。

多發(fā)性硬化癥/Multiple Sclerosis (MS)

多發(fā)性硬化癥是一種慢性中樞神經(jīng)系統(tǒng)（CNS）炎癥性疾病，導(dǎo)致脫髓鞘和神經(jīng)變性。MS的臨床表現(xiàn)多樣，包括運(yùn)動(dòng)障礙、感覺異常、視覺障礙、精神癥狀及認(rèn)知障礙等。多發(fā)性硬化癥的藥物研究靶點(diǎn)主要集中在B細(xì)胞和T細(xì)胞、鞘氨醇-1-磷酸鹽受體（S1PR）、Nrf2通路、鉀離子通道、α2-腎上腺素能受體、Syk激酶、S1P1受體、CD20陽性B細(xì)胞、免疫抑制藥物、線粒體保護(hù)劑、離子通道以及谷氨酸介導(dǎo)的興奮性毒性等，這些靶點(diǎn)涉及免疫調(diào)節(jié)、神經(jīng)保護(hù)和細(xì)胞損傷等多個(gè)方面。

亨廷頓病/Huntington's Disease (HD)

亨廷頓?。℉untington's Disease, HD）是一種罕見的常染色體顯性遺傳性神經(jīng)系統(tǒng)變性疾病，典型表現(xiàn)包括逐漸進(jìn)展的舞蹈樣動(dòng)作、認(rèn)知障礙和精神行為異常。亨廷頓病的發(fā)病機(jī)制主要與亨廷頓基因（HTT）上的CAG三核苷酸異常重復(fù)有關(guān)，這種異常重復(fù)導(dǎo)致多聚谷氨酰胺鏈的產(chǎn)生，進(jìn)而編碼出異常的亨廷頓蛋白（mHTT），該蛋白在中樞神經(jīng)系統(tǒng)累積，導(dǎo)致神經(jīng)元損傷和死亡。亨廷頓病的藥物研究主要集中在降低突變亨廷頓蛋白（mHTT）的表達(dá)和水平、激活細(xì)胞自噬途徑促進(jìn)mHTT降解、以及對癥治療改善運(yùn)動(dòng)和精神癥狀等方面。

神經(jīng)科學(xué)研究推薦產(chǎn)品

重組蛋白

Recombinant Human Interleukin-17A (IL17A)
CSB-BP624104HU(M)
CSB-BP624104HU(M) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL17A at 2 μg/ml can bind Anti-IL17A recombinant antibody (CSB-RA624104MA1HU), the EC50 is 1.818-2.170 ng/mL.

Recombinant Human Interleukin-6 (IL6)
CSB-YP011664HU
CSB-YP011664HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU)，the EC50 is 35.80-41.82 ng/mL.

Recombinant Human Microtubule-associated protein tau (MAPT)
CSB-MP013481HU(F8)
CSB-MP013481HU(F8) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human MAPT at 2 μg/ml can bind Anti-MAPT recombinant antibody (CSB-RA013481A1HU), the EC50 is 4.547-6.284 ng/mL.

Recombinant Human Angiopoietin-2 (ANGPT2)
CSB-MP001707HU(A4)
CSB-MP001707HU(A4) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL

產(chǎn)品名稱 貨號 靶點(diǎn) 來源 蛋白標(biāo)簽
Recombinant Macaca mulatta Interleukin-10 (IL10) CSB-EP011580MOW IL10 E.coli N-terminal 6xHis-B2M-tagged
Recombinant Macaca mulatta Interleukin-10 (IL10) CSB-BP011580MOW IL10 Baculovirus N-terminal 10xHis-tagged and C-terminal myc-tagged
Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial CSB-EP011087HUa0 IGF1R E.coli N-terminal 6xHis-tagged
Recombinant Bovine Insulin-like growth factor I (IGF1) CSB-YP011086BO IGF1 Yeast N-terminal hFc-tagged
Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial CSB-EP011087HU IGF1R E.coli N-terminal GST-tagged
Recombinant Human Insulin-like growth factor I (IGF1), partial (Active) CSB-AP003721HU IGF1 E.coli Tag-Free
Recombinant Rat Insulin-like growth factor I (Igf1) CSB-EP362300RA Igf1 E.coli N-terminal GST-tagged
Recombinant Human Insulin-like growth factor I (IGF1) CSB-EP356436HUe0 IGF1 E.coli N-terminal GST-tagged
Recombinant Human Insulin-like growth factor I (IGF1) CSB-EP356436HU IGF1 E.coli N-terminal 6xHis-tagged
Recombinant Dog Interferon gamma (IFNG) CSB-EP011050DO IFNG E.coli C-terminal 6xHis-tagged
Recombinant Mesocricetus auratus Interferon gamma (IFNG) CSB-EP011050MRGm1 IFNG E.coli N-terminal 6xHis-tagged and C-terminal Strep II-tagged
Recombinant Macaca fascicularis Interferon gamma (IFNG) CSB-YP011050MOV IFNG Yeast C-terminal 6xHis-tagged
Recombinant Macaca fascicularis Interferon gamma (IFNG) CSB-EP011050MOV IFNG E.coli C-terminal 6xHis-tagged
Recombinant Human Interferon gamma (IFNG) (Active) CSB-AP004201HU IFNG E.coli Tag-Free
Recombinant Rhesus Macaque Interferon gamma protein (IFNG) (Active) CSB-AP003241MOW IFNG E.Coli Tag-Free
Recombinant Human Interferon gamma protein (IFNG) (Active) CSB-AP002801HU IFNG E.Coli Tag-Free
Recombinant Goat Interferon gamma (IFNG) CSB-EP011050GO IFNG E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Sheep Interferon gamma (IFNG) CSB-YP011050SH IFNG Yeast N-terminal 6xHis-tagged
Recombinant Marmota monax Interferon gamma (IFNG) CSB-YP011050MQG IFNG Yeast N-terminal 6xHis-tagged
Recombinant Guinea Pig Interferon gamma (Ifng), partial CSB-EP1470GP1 Ifng E.coli N-terminal 6xHis-tagged

抗體

Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody
Code：CSB-RA001553A473phHU
CSB-RA001553A473phHU-WB

WB (1:500-1:5000)

CSB-RA001553A473phHU-IHC

IHC (1:50-1:200)

CSB-RA001553A473phHU-IF

IF (1:20-1:200)

CSB-RA001553A473phHU-IP

IP (1:200-1:1000)

GFAP Recombinant Monoclonal Antibody
Code：CSB-RA009369MA1HU
CSB-RA009369MA1HU-WB

WB (1:500-1:5000)

CSB-RA009369MA1HU-IHC

IHC (1:50-1:200)

CSB-RA009369MA1HU-IF

IF (1:20-1:200)

CSB-RA009369MA1HU-FC

IP (1:200-1:1000)

● 重組抗體：

產(chǎn)品名稱 貨號 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
ACVR2B Recombinant Monoclonal Antibody CSB-RA260702A0HU ACVR2B Human ELISA, IHC
Phospho-AKT1 (T450) Recombinant Monoclonal Antibody CSB-RA001553A450phHU AKT1 Human ELISA, WB
Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody CSB-RA001553A473phHU AKT1 Human ELISA, WB, IHC, IF, IP
AKT1 Recombinant Monoclonal Antibody CSB-RA917625A0HU AKT1 Human, Mouse, Rat ELISA, WB, IHC, IF
ALB Recombinant Monoclonal Antibody CSB-RA264109A0HU ALB Human ELISA, FC
ANGPT2 Recombinant Monoclonal Antibody CSB-RA191985A0HU ANGPT2 Human ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody CSB-RA001707MA01HU ANGPT2 Human ELISA
APP Recombinant Monoclonal Antibody CSB-RA994273A0HU APP Human, Mouse, Rat ELISA, WB, IF
BACE1 Recombinant Monoclonal Antibody CSB-RA177574A0HU BACE1 Human, Mouse, Rat ELISA, WB
BCHE Recombinant Monoclonal Antibody CSB-RA252650A0HU BCHE Human ELISA, WB
BDNF Recombinant Monoclonal Antibody CSB-RA989910A0HU BDNF Human, Mouse ELISA, WB
C3 Recombinant Monoclonal Antibody CSB-RA303909A0HU C3 Human ELISA, WB, IHC, FC
C3 Recombinant Monoclonal Antibody CSB-RA699863A0HU C3 Human ELISA, IHC
C5 Recombinant Monoclonal Antibody CSB-RA003995MA1HU C5 Human ELISA, FC
CD19 Recombinant Monoclonal Antibody CSB-RA004888A0HU CD19 Human ELISA
CD19 Recombinant Monoclonal Antibody CSB-RA780821A0HU CD19 Human ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody CSB-RA004888MA1HU CD19 Human, Mouse ELISA, WB
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC

● 單克隆抗體：

產(chǎn)品名稱 貨號 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
AKT1 Monoclonal Antibody CSB-MA011037 AKT1 Human,Mouse,Pig,Rat ELISA, WB
ALB Monoclonal Antibody CSB-MA076752 ALB Human ELISA, WB, IHC
APP Monoclonal Antibody CSB-MA0019501A0m APP Human, Mouse ELISA, WB, IHC, IF
CD19 Monoclonal Antibody CSB-MA004888A0m CD19 Human ELISA, WB, IHC, IF, FC
CD19 Monoclonal Antibody CSB-MA004888A1m CD19 Human ELISA, WB, IHC, FC
CD19 Monoclonal Antibody,Purified CSB-MA798261 CD19 Human ELISA, FC
CD38 Monoclonal Antibody CSB-MA785760 CD38 Human ELISA, IHC
CD3E Monoclonal Antibody,Purified CSB-MA947479 CD3E Human ELISA, IF, FC
CD4 Monoclonal Antibody CSB-MA000228 CD4 Human,Mouse,Rat ELISA, IHC
CD4 Monoclonal Antibody,Purified CSB-MA783233 CD4 Human ELISA, FC
CD8A Monoclonal Antibody,Purified CSB-MA927984 CD8A Human ELISA, FC
CTLA4 Monoclonal Antibody CSB-MA006163A0m CTLA4 Human ELISA, WB, IHC
EGFR Monoclonal Antibody CSB-MA000199 EGFR Human ELISA, WB, IHC, IF
EGFR Monoclonal Antibody CSB-MA000293 EGFR Human ELISA, WB
ERBB2 Monoclonal Antibody CSB-MA000200 ERBB2 Human,Mouse,Rat ELISA, WB, IHC
ERBB2 Monoclonal Antibody CSB-MA000237 ERBB2 Human ELISA, WB
ERBB2 Monoclonal Antibody CSB-MA172796 ERBB2 Human ELISA, WB, IHC
FN1 Monoclonal Antibody CSB-MA000296 FN1 Human,Mouse,Rat ELISA, WB
FN1 Monoclonal Antibody CSB-MA000318 FN1 Mouse,Rat,Human ELISA, WB
FOXP3 Monoclonal Antibody CSB-MA545218 FOXP3 Human ELISA, WB

● 多克隆抗體：

產(chǎn)品名稱 貨號 靶點(diǎn) 反應(yīng)種屬 應(yīng)用范圍
ABCD1 Antibody CSB-PA001068LA01HU ABCD1 Human ELISA, IHC
ABCD1 Antibody CSB-PA008163 ABCD1 Human ELISA, WB
ABCD1 Antibody CSB-PA001068GA01HU ABCD1 Human, Mouse, Rat ELISA, WB, IHC
ABCD1 Antibody CSB-PA214656 ABCD1 Human ELISA, WB
ACHE Antibody CSB-PA5619A0Rb ACHE Human ELISA, IHC, IF
ache Antibody CSB-PA863598LA01DIL ache Zebrafish ELISA, WB
ACHE Antibody CSB-PA010202 ACHE Human, Mouse, Rat ELISA, WB, IHC
ACHE Antibody CSB-PA010203 ACHE Human, Mouse, Rat ELISA, WB
ACHE Antibody CSB-PA001154GA01HU ACHE Human, Mouse, Rat ELISA, WB
ACHE Antibody CSB-PA904467 ACHE Human, Mouse, Rat ELISA, WB
ACHE Antibody CSB-PA114463 ACHE Human, Mouse, Rat ELISA, WB, IHC
ACHE Antibody CSB-PA547258 ACHE Human ELISA, WB
ACVR2B Antibody CSB-PA623829ESR1HU ACVR2B Human ELISA, IHC
ACVR2B Antibody CSB-PA292270 ACVR2B Human, Mouse, Rat ELISA, IHC
ACVR2B Antibody CSB-PA206692 ACVR2B Human, Mouse, Rat ELISA, WB, IHC
ADCYAP1R1 Antibody CSB-PA207627 ADCYAP1R1 Human, Mouse ELISA, WB, IHC
AGER Antibody CSB-PA14209A0Rb AGER Human ELISA, IHC, IF
AGER Antibody CSB-PA007810 AGER Human ELISA, WB, IHC
AGER Antibody CSB-PA066696 AGER Human ELISA, WB, IHC
AGER Antibody CSB-PA874417 AGER Human ELISA, WB, IHC

ELISA試劑盒

產(chǎn)品名稱 貨號 靶點(diǎn) 檢測范圍 靈敏度
Human Acetylcholinesterase,AChE ELISA Kit CSB-E09670h ACHE 0.94 mU/mL-60 mU/mL 0.23 mU/mL
Rat Acetylcholinesterase,AChE ELISA Kit CSB-E11304r ACHE 7.8 pg/mL-500 pg/mL 1.95 pg/mL
Fish Acetylcholinesterase(AChE)ELISA Kit CSB-E17001Fh AChE 2.5 ng/mL-40 ng/mL 2.5 ng/mL
Mouse Acetylcholinesterase(AChE)ELISA Kit CSB-E17521m AChE 0.312 mU/mL-20 mU/mL 0.078 mU/mL
Human Receptor for advanced glycation end products, RAGE/AGER ELISA Kit CSB-E09354h AGER 78 pg/mL-5000 pg/mL 19.5 pg/mL
Rat Advanced glycosylation end product-specific receptor(AGER) ELISA kit CSB-EL001441RA AGER 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Mouse Advanced glycosylation end product-specific receptor(AGER) ELISA kit CSB-EL001441MO AGER 0.312 ng/ml-20 ng/ml 0.078 ng/ml
Human RAC-alpha serine/threonine-protein kinase(AKT1) ELISA kit CSB-EL001553HU AKT1 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Bovine Albumin(Alb) ELISA kit CSB-E08664b ALB 0.313 μg/mL-80 μg/mL 0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit CSB-E13878m ALB 0.781 μg/mL-200 μg/mL 0.110 μg/mL
Dog Albumin(Alb) ELISA Kit CSB-E15757c ALB 0.273 μg/mL-35 μg/mL 0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit CSB-E15839Sh ALB 350 μg/mL-21.88 μg/mL 5.5 μg/mL
Horse Albumin(Alb) ELISA Kit CSB-E16205Hs ALB 1.25 μg/mL-80 μg/mL 1.247 μg/mL
Pig Albumin (Alb) ELISA Kit CSB-E16207p ALB 0.03 μg/mL-7000 μg/mL 0.03 μg/mL
Goat Albumin (Alb)ELISA Kit CSB-E15758G ALB 0.17 μg/mL-350 μg/mL 0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit CSB-E15765Gp ALB 0.156 μg/mL-10 μg/mL 0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit CSB-E16204Rb ALB 0.273 μg/mL-70 μg/mL 0.117 μg/mL
Human Angiopoietin 2,ANG-2 ELISA Kit CSB-E04500h ANGPT2 39 pg/mL-2500 pg/mL 9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit CSB-E07304r ANGPT2 Request Information Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit CSB-E07305m ANGPT2 0.156 pg/mL-10 pg/mL 0.039 pg/mL

神經(jīng)細(xì)胞培養(yǎng)常用細(xì)胞因子

細(xì)胞因子 作用 華美生物推薦產(chǎn)品
貨號 種屬 表達(dá)系統(tǒng) 標(biāo)簽
BDNF 腦源性神經(jīng)營養(yǎng)因子，支持神經(jīng)元存活和促進(jìn)其成熟，對學(xué)習(xí)和記憶過程至關(guān)重要 CSB-AP003781HU Human E.coli Tag-Free
CNTF 睫狀神經(jīng)營養(yǎng)因子，促進(jìn)神經(jīng)細(xì)胞的存活，對神經(jīng)退行性疾病具有潛在的治療作用 CSB-AP002841HU Human E.Coli Tag-Free
EGF 表皮生長因子，促進(jìn)多種細(xì)胞類型的生長和增殖，特別是上皮細(xì)胞 CSB-AP003711HU Human E.coli Tag-Free
CSB-AP004091MO Mouse E.coli C-terminal 6xHis-tagged
aFGF (FGF1) 酸性成纖維細(xì)胞生長因子，促進(jìn)細(xì)胞的增殖和分化，尤其在受損組織修復(fù)中發(fā)揮作用 CSB-AP003761HU Human E.coli Tag-Free
bFGF (FGF2) 促進(jìn)神經(jīng)干細(xì)胞和前體細(xì)胞的增殖，同時(shí)有助于傷口愈合和血管生成 CSB-AP003751HU Human E.coli Tag-Free
CSB-AP003831HU Human E.coli Tag-Free
CSB-AP003841HU Human E.coli Tag-Free
CSB-AP004061MO Mouse E.coli Tag-Free
CSB-AP004171RA Rat E.coli Tag-Free
GDNF 膠質(zhì)細(xì)胞源性神經(jīng)營養(yǎng)因子，對多巴胺能神經(jīng)元的存活和再生具有重要作用 CSB-AP002881HU Human E.Coli Tag-Free
IGF1 胰島素樣生長因子，促進(jìn)細(xì)胞增殖和分化，對神經(jīng)系統(tǒng)的發(fā)育和再生具有積極作用 CSB-AP003701HU Human E.coli Tag-Free
CSB-AP003721HU Human E.coli Tag-Free
CSB-AP003731HU Human E.coli Tag-Free
NGF 神經(jīng)生長因子，促進(jìn)神經(jīng)細(xì)胞生長和存活，特別是在感覺神經(jīng)元和交感神經(jīng)元的發(fā)育中 CSB-AP003771HU Human E.coli Tag-Free
CSB-AP003951HU Human Mammalian cell Tag-Free
CSB-AP004081MO Mouse E.coli Tag-Free