BACE1

BACE1，即β-分泌酶1，別名BACE、KIAA1149、ASP2，它主要來源于11號(hào)染色體上的基因。BACE1是一種天冬氨酸蛋白酶，其作用機(jī)制是通過剪切淀粉樣前體蛋白（APP），產(chǎn)生β-淀粉樣蛋白（Aβ），這一過程在阿爾茨海默?。ˋD）的發(fā)病中起到關(guān)鍵作用。此外，BACE1還涉及心血管代謝疾病的發(fā)生發(fā)展，如糖尿病和動(dòng)脈粥樣硬化。作為重要的生物學(xué)靶點(diǎn)，BACE1的抑制劑已被研發(fā)用于AD治療，并展現(xiàn)出對(duì)代謝性疾病的潛在治療效果。盡管其確切的生物學(xué)意義和全部功能仍在深入研究中，但BACE1已成為神經(jīng)科學(xué)和藥物研發(fā)領(lǐng)域的熱點(diǎn)之一。

熱銷產(chǎn)品

BACE1 Recombinant Monoclonal Antibody (CSB-RA177574A0HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Rat brain tissue, Mouse brain tissue
All lanes: BACE1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56, 53, 52, 49, 46, 43 kDa
Observed band size: 72 kDa

Human β-site APP-Cleaving Enzyme 1,BACE1 ELISA kit (CSB-E09824h)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-E09824h

規(guī)格：96T/48T

靈敏度：0.78 pg/mL

檢測(cè)范圍：3.12 pg/mL-200 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

BACE1 Antibody

BACE1 Protein

BACE1 ELISA Kit

BACE1 Antibodies

BACE1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA002524GA01HU	BACE1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA008418	BACE1 Antibody	Human,Mouse,Rat	IHC, IF, ELISA
CSB-PA173556	BACE1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA150463	BACE1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA002524LA01HU	BACE1 Antibody	Human	ELISA, IHC, IF
CSB-PA002524LB01HU	BACE1 Antibody, HRP conjugated	Human	ELISA
CSB-PA002524LC01HU	BACE1 Antibody, FITC conjugated	Human
CSB-PA002524LD01HU	BACE1 Antibody, Biotin conjugated	Human	ELISA
CSB-RA177574A0HU	BACE1 Recombinant Monoclonal Antibody	Human, Mouse, Rat	ELISA, WB

BACE1 Proteins

BACE1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP002524HU1 CSB-EP002524HU1 CSB-BP002524HU1 CSB-MP002524HU1 CSB-EP002524HU1-B	Recombinant Human Beta-secretase 1 (BACE1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF002524HU	Recombinant Human Beta-secretase 1 (BACE1)	in vitro E.coli expression system