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Gpi Antibody, FITC conjugated

  • 中文名稱：
    Gpi兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA009717LC01MO
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Mus musculus (Mouse) Gpi Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    Gpi
  • 別名：
    Gpi antibody; Gpi1Glucose-6-phosphate isomerase antibody; GPI antibody; EC 5.3.1.9 antibody; Autocrine motility factor antibody; AMF antibody; Neuroleukin antibody; NLK antibody; Phosphoglucose isomerase antibody; PGI antibody; Phosphohexose isomerase antibody; PHI antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Mouse
  • 免疫原：
    Recombinant Mouse Glucose-6-phosphate isomerase protein (2-558AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion.
  • 基因功能參考文獻(xiàn)：
    1. PGI is a moonlighting protein that functions as a cytosolic enzyme involved in glycolysis and gluconeogenesis, and as cytokine through binding to its cell surface receptor. PMID: 8674049
    2. The mGPI-transgenic mice presented GPI more efficiently and showed a dramatic increase in negative selection and an inhibition of arthritis. PMID: 23840022
    3. Data show that silencing of AMF/PGI induced MET and suppressed the tumor growth and pulmonary metastasis of LM8 cells in nude mice. PMID: 20978190
    4. induces hyperpermeability of endothelial and mesothelial cells leading to accumulation of ascites fluid (tumor autocrine motility factor) PMID: 12054583
    5. acid-induced conformational changes in phosphoglucose isomerase result in its increased cell surface association and deposition on fibronectin fibrils PMID: 12888574
    6. Gpi1 immunoreactivity was found in ganglion, amacrine, horizontal and bipolar cells, but not in rods, cones, pigment epithelium and Muller cells. PMID: 15182299
    7. High-resolution crystal structures of the enzyme from mouse have been determined in native form and in complex with the inhibitor erythrose 4-phosphate, and with the substrate glucose 6-phosphate. PMID: 15342241
    8. crystal structure of Autocrine Motility Factor PMID: 15502335
    9. AMF expression significantly contributes to the aggressive phenotype of pancreatic cancer PMID: 15570012
    10. Results report the first high-resolution crystal structure of the inhibitor-free form and the eight types of inhibitor complexes of mouse autocrine motility factor. PMID: 16375918
    11. the receptor molecule for AMF/NLK/MF in leukemic differentiation is not gp78 PMID: 17071500

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  • 亞細(xì)胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    GPI family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: mmu:14751

    STRING: 10090.ENSMUSP00000049355

    UniGene: Mm.589