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USP16

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

USP16 Antibodies

USP16 for Homo sapiens (Human)

USP16 Proteins

USP16 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

USP16 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

USP16 Proteins for Rattus norvegicus (Rat)

USP16 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

USP16 Proteins for Xenopus laevis (African clawed frog)

USP16 Proteins for Mus musculus (Mouse)

USP16 Proteins for Homo sapiens (Human)