USP16 Antibody
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中文名稱:USP16兔多克隆抗體
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貨號(hào):CSB-PA025706GA01HU
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規(guī)格:¥3,900
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:
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別名:Deubiquitinating enzyme 16 antibody; Human ubiquitin processing protease antibody; MSTP039 antibody; Ubiquitin carboxyl-terminal hydrolase 16 antibody; Ubiquitin Specific peptidase 16 antibody; Ubiquitin Specific Protease 16 antibody; Ubiquitin thiolesterase 16 antibody; Ubiquitin-processing protease UBP-M antibody; Ubiquitin-specific-processing protease 16 antibody; UBP M antibody; UBP16_HUMAN antibody; UBPM antibody; usp16 antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Human USP16
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免疫原種屬:Homo sapiens (Human)
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抗體亞型:IgG
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純化方式:Antigen Affinity purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,WB,IHC
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Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
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基因功能參考文獻(xiàn):
- USP16 was frequently downregulated. PMID: 27633997
- USP16 and TTC3 were dysregulated in all affected human cells and two mouse models of Down syndrome. PMID: 27586445
- The data unveil a unique mechanism by which Usp16 promotes the localization and maintenance of Plk1 on the kinetochores for proper chromosome alignment. PMID: 26323689
- Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal. PMID: 25305019
- S552P disrupts the interaction between Ubp-M and nuclear export protein CRM1, increasing Ubp-M nuclear retention as cells progress into M phase, revealing a critical function for Ubp-M S552P. PMID: 24013421
- in human tissues overexpression of USP16 reduces the expansion of normal fibroblasts and postnatal neural progenitors, whereas downregulation of USP16 partially rescues the proliferation defects of Down's syndrome fibroblasts PMID: 24025767
- Study reports the solution structure of the BUZ domain of Ubp-M, a ubiquitin-specific protease, and its interaction with ubiquitin; the Ubp-M BUZ domain features three zinc-binding sites consisting of 12 residues. PMID: 17512543
- knockdown of Ubp-M in HeLa cells results in slow cell growth rates owing to defects in the mitotic phase of the cell cycle PMID: 17914355
- a new cryptic USP16-RUNX1 fusion in chronic myelomonocytic leukemia PMID: 18925961
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相關(guān)疾病:A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1.
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亞細(xì)胞定位:Nucleus.
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蛋白家族:Peptidase C19 family, USP16 subfamily
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組織特異性:Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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數(shù)據(jù)庫(kù)鏈接:
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