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CLDN6

CLDN6:癌癥治療新寵

CLDN6位于染色體16p3.3,分子量大約20-40kDa。Claudins成員之間具有相似的結(jié)構(gòu),每個Claudin分子有4個跨膜結(jié)構(gòu)域,2個細胞外環(huán)和2條胞內(nèi)尾區(qū)。CLDN6擁有一個C端的PDZ結(jié)合位點,使得緊密連接蛋白能與細胞內(nèi)某些蛋白發(fā)生相互作用關(guān)系,在細胞連接及上皮組織通透性等方面均可發(fā)揮重要作用

越來越多的研究表明,CLDN6異常表達可參與乳腺癌,卵巢癌,宮頸癌,胃癌,肺癌等多種惡性腫瘤發(fā)生及發(fā)展過程。CLDN6作為細胞骨架的形成和細胞信號通路調(diào)節(jié)的重要分子,可影響細胞的生長進程,這為腫瘤的診斷和干預(yù)提供了新的方向。目前,多款針對CLDN6的藥物已處于臨床和臨床前階段,用于多種腫瘤的治療。

CUSABIO-哺乳包膜VIPs平臺成功開發(fā)CLDN6全長跨膜蛋白(4次跨膜),展示了完整生物活性。

熱銷產(chǎn)品

Recombinant Human Claudin-6(CLDN6)-VLPs (Active) (CSB-MP005508HU(A4))

驗證數(shù)據(jù)

WB
CSB-MP005508HU(A4) WB

CSB-MP005508HU(A4) is detected by Mouse anti-6*His monoclonal antibody.

ELISA
CSB-MP005508HU(A4) ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 at 10 μg/ml can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU), the EC50 is 1.501-2.035 ng/mL

TEM
CSB-MP005508HU(A4) TEM

The presence of VLP-like structures was confirmed by TEM

CLDN6/9 Recombinant Monoclonal Antibody CSB-RA005508MA1HU

驗證數(shù)據(jù)

ELISA
CSB-RA005508MA1HU ELISA

The Binding Activity of Huamn CLDN6 with Anti-CLDN6/9 recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 (CSB-MP005508HU(A4)) at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody, the EC50 is 1.501-2.035 ng/mL.

ELISA
CSB-RA005508MA1HU ELISA

The Binding Activity of Human CLDN9 with Anti-CLDN6/9 Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 (CSB-MP005511HU) at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody, the EC50 is 24.93-35.47 ng/mL.

TEM
RA005508MA1HU FC

Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 recombinant antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CLDN6 Antibodies

CLDN6 for Homo sapiens (Human)

CLDN6 Proteins

CLDN6 Proteins for Homo sapiens (Human)

CLDN6 Proteins for Homo sapiens(Human)