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趨化因子

趨化因子(chemokines)是指能夠吸引白細(xì)胞移行到感染部位的一些小分子細(xì)胞因子家族蛋白,在炎癥反應(yīng)中具有重要作用。趨化因子蛋白是一個(gè)大家族,但是基本都會(huì)有一些共同結(jié)構(gòu)特征,包括分子量?。s8-10 千道爾頓),有四個(gè)位置保守的半胱氨酸殘基以保證其三級(jí)結(jié)構(gòu)。此外,他們大約有20-50%的序列完全相同,這些小蛋白因其有定向細(xì)胞趨化作用而得名。

有的趨化因子被認(rèn)為促進(jìn)炎癥反應(yīng),而有些趨化因子被認(rèn)為在正常的修復(fù)過(guò)程或發(fā)育中控制細(xì)胞的遷徙。趨化因子存在于所有脊椎動(dòng)物、部分病毒和細(xì)菌中,但不存在于其他無(wú)脊椎動(dòng)物。這些蛋白質(zhì)通常是通過(guò)與細(xì)胞表面的趨化因子受體結(jié)合而起作用,趨化因子受體是G蛋白偶聯(lián)受體,選擇性地表達(dá)在靶細(xì)胞表面。趨化因子可以根據(jù)給定趨化因子的濃度梯度誘導(dǎo)靶細(xì)胞與內(nèi)皮的牢固粘附,并指導(dǎo)靶細(xì)胞運(yùn)動(dòng)到目的地。

產(chǎn)品名稱 貨號(hào) 規(guī)格
Recombinant Mouse C-X-C motif chemokine 14 protein (Cxcl14) CSB-AP001181MO 500ug/100ug/5ug
Recombinant Mouse C-X-C motif chemokine 16 protein (Cxcl16), partial (Active) CSB-AP001191MO 500ug/100ug/5ug
Recombinant Mouse Fractalkine protein (Cx3cl1), partial (Active) CSB-AP001211MO 500ug/100ug/5ug
Recombinant Mouse C-C motif chemokine 3 protein (Ccl3) CSB-AP001221MO 500ug/100ug/10ug
Recombinant Mouse C-C motif chemokine 4 protein (Ccl4) CSB-AP001231MO 500ug/100ug/10ug
Recombinant Mouse C-C motif chemokine 5 protein (Ccl5) CSB-AP001241MO 500ug/100ug/5ug
Recombinant Mouse C-C motif chemokine 6 protein (Ccl6) CSB-AP001251MO 500ug/100ug/10ug
Recombinant Mouse C-C motif chemokine 7 protein (Ccl7) CSB-AP001261MO 500ug/100ug/10ug
Recombinant Mouse C-C motif chemokine 8 protein (Ccl8) CSB-AP001271MO 500ug/100ug/5ug
Recombinant Mouse C-C motif chemokine 9 protein (Ccl9) CSB-AP001281MO 500ug/100ug/5ug
Recombinant Mouse Eotaxin protein (Ccl11) CSB-AP001291MO 500ug/100ug/5ug
Recombinant Mouse C-C motif chemokine 12 protein (Ccl12) CSB-AP001301MO 500ug/100ug/5ug
Recombinant Mouse protein C-C motif chemokine (Ccl17) CSB-AP001311MO 500ug/100ug/5ug
Recombinant Mouse C-C motif chemokine 19 protein (Ccl19) CSB-AP001321MO 500ug/100ug/5ug
Recombinant Mouse C-C motif chemokine 20 protein (Ccl20) CSB-AP001331MO 500ug/100ug/5ug
Recombinant Mouse C-C motif chemokine 21c protein (Ccl21c) CSB-AP001341MO 500ug/100ug/5ug
Recombinant Mouse C-C motif chemokine 22 protein (Ccl22) CSB-AP001351MO 500ug/100ug/5ug
Recombinant Mouse C-C motif chemokine 24 protein (Ccl24) CSB-AP001361MO 500ug/100ug/5ug
Recombinant Mouse C-C motif chemokine 25 protein (Ccl25) CSB-AP001371MO 500ug/100ug/5ug
Recombinant Mouse C-C motif chemokine 27 protein (Ccl27), partial (Active) CSB-AP001381MO 500ug/100ug/5ug

趨化因子的主要作用是趨化細(xì)胞的遷移。細(xì)胞沿著趨化因子濃度增加的信號(hào)向趨化因子源處的遷徙。關(guān)于趨化因子的作用機(jī)制目前已經(jīng)明了。

趨化因子通過(guò)與在細(xì)胞表面選擇性表達(dá)的趨化因子受體相互作用后傳遞細(xì)胞信號(hào),趨化因子受體是與G蛋白偶聯(lián)的7-跨膜蛋白。趨化因子受體激活G蛋白后,活化磷脂酶C(PLC)的酶,PLC將磷脂酰肌醇(4,5)-二磷酸(PIP2)分裂成肌醇三磷酸(IP3)和二酰基甘油(DAG),然后這IP3和DAG作為第二信使分子可觸發(fā)細(xì)胞內(nèi)一系列信號(hào)傳導(dǎo)。DAG激活另一種叫做蛋白激酶C(PKC)的酶,IP3觸發(fā)細(xì)胞內(nèi)鈣的釋放。這些反應(yīng)會(huì)進(jìn)一步促進(jìn)許多信號(hào)級(jí)聯(lián)反應(yīng)(例如MAP激酶途徑),同時(shí)對(duì)胞內(nèi)的一系列反應(yīng),細(xì)胞會(huì)表現(xiàn)出對(duì)應(yīng)的趨化性、脫粒、超氧陰離子的釋放和細(xì)胞粘附分子的親合力改變等變化。