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趨化因子

趨化因子(chemokines)是指能夠吸引白細(xì)胞移行到感染部位的一些小分子細(xì)胞因子家族蛋白,在炎癥反應(yīng)中具有重要作用。趨化因子蛋白是一個(gè)大家族,但是基本都會(huì)有一些共同結(jié)構(gòu)特征,包括分子量小(約8-10 千道爾頓),有四個(gè)位置保守的半胱氨酸殘基以保證其三級(jí)結(jié)構(gòu)。此外,他們大約有20-50%的序列完全相同,這些小蛋白因其有定向細(xì)胞趨化作用而得名。

有的趨化因子被認(rèn)為促進(jìn)炎癥反應(yīng),而有些趨化因子被認(rèn)為在正常的修復(fù)過程或發(fā)育中控制細(xì)胞的遷徙。趨化因子存在于所有脊椎動(dòng)物、部分病毒和細(xì)菌中,但不存在于其他無脊椎動(dòng)物。這些蛋白質(zhì)通常是通過與細(xì)胞表面的趨化因子受體結(jié)合而起作用,趨化因子受體是G蛋白偶聯(lián)受體,選擇性地表達(dá)在靶細(xì)胞表面。趨化因子可以根據(jù)給定趨化因子的濃度梯度誘導(dǎo)靶細(xì)胞與內(nèi)皮的牢固粘附,并指導(dǎo)靶細(xì)胞運(yùn)動(dòng)到目的地。

產(chǎn)品名稱 貨號(hào) 規(guī)格
Recombinant Human C-C motif chemokine 24 protein (CCL24), partial (Active) CSB-AP000971HU 500ug/100ug/5ug
Recombinant Human C-C motif chemokine 25 protein (CCL25) CSB-AP000981HU 500ug/100ug/5ug
Recombinant Human C-C motif chemokine 26 protein (CCL26) CSB-AP000991HU 500ug/100ug/5ug
Recombinant Human C-C motif chemokine 27 protein (CCL27) CSB-AP001001HU 500ug/100ug/5ug
Recombinant Human C-C motif chemokine 28 protein (CCL28) CSB-AP001011HU 500ug/100ug/5ug
Recombinant Human Protein FAM19A2 protein (FAM19A2) CSB-AP001021HU 500ug/100ug/5ug
Recombinant Macaca mulatta C-X-C motif chemokine 10 protein (CXCL10) CSB-AP001031MOW 500ug/100ug/5ug
Recombinant Rhesus Macaque Eotaxin protein (CCL11) CSB-AP001041MOW 500ug/100ug/5ug
Recombinant Mouse Growth-regulated alpha protein (Cxcl1) CSB-AP001061MO 500ug/100ug/5ug
Recombinant Mouse C-X-C motif chemokine 2 protein (Cxcl2) CSB-AP001071MO 500ug/100ug/5ug
Recombinant Mouse C-C motif chemokine 28 protein (Ccl28), partial (Active) CSB-AP001081MO 500ug/100ug/5ug
Recombinant Mouse C-X-C motif chemokine 3 protein (Cxcl3), partial (Active) CSB-AP001091MO 500ug/100ug/10ug
Recombinant Mouse Platelet factor 4 (Pf4) CSB-AP001101MO 500ug/100ug/5ug
Recombinant Mouse C-X-C motif chemokine 5 protein (Cxcl5), partial (Active) CSB-AP001111MO 500ug/100ug/5ug
Recombinant Mouse C-X-C motif chemokine 5 protein (Cxcl5) (Active) CSB-AP001121MO 500ug/100ug/5ug
Recombinant Mouse C-X-C motif chemokine 9 protein (Cxcl9), partial (Active) CSB-AP001131MO 500ug/100ug/5ug
Recombinant Mouse C-X-C motif chemokine 10 protein (Cxcl10) CSB-AP001141MO 500ug/100ug/5ug
Recombinant Mouse C-X-C motif chemokine 11 protein (Cxcl11) CSB-AP001151MO 500ug/100ug/5ug
Recombinant Mouse Stromal cell-derived factor 1 protein (Cxcl12), partial (Active) CSB-AP001161MO 500ug/100ug/10ug
Recombinant Mouse Stromal cell-derived factor 1 protein (Cxcl12) CSB-AP001171MO 500ug/100ug/10ug

趨化因子的主要作用是趨化細(xì)胞的遷移。細(xì)胞沿著趨化因子濃度增加的信號(hào)向趨化因子源處的遷徙。關(guān)于趨化因子的作用機(jī)制目前已經(jīng)明了。

趨化因子通過與在細(xì)胞表面選擇性表達(dá)的趨化因子受體相互作用后傳遞細(xì)胞信號(hào),趨化因子受體是與G蛋白偶聯(lián)的7-跨膜蛋白。趨化因子受體激活G蛋白后,活化磷脂酶C(PLC)的酶,PLC將磷脂酰肌醇(4,5)-二磷酸(PIP2)分裂成肌醇三磷酸(IP3)和二?;视停―AG),然后這IP3和DAG作為第二信使分子可觸發(fā)細(xì)胞內(nèi)一系列信號(hào)傳導(dǎo)。DAG激活另一種叫做蛋白激酶C(PKC)的酶,IP3觸發(fā)細(xì)胞內(nèi)鈣的釋放。這些反應(yīng)會(huì)進(jìn)一步促進(jìn)許多信號(hào)級(jí)聯(lián)反應(yīng)(例如MAP激酶途徑),同時(shí)對(duì)胞內(nèi)的一系列反應(yīng),細(xì)胞會(huì)表現(xiàn)出對(duì)應(yīng)的趨化性、脫粒、超氧陰離子的釋放和細(xì)胞粘附分子的親合力改變等變化。