Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse ATP-binding cassette sub-family A member 1 (Abca1), partial

Recombinant Mouse ATP-binding cassette sub-family A member 1 (Abca1), partial

  • 中文名稱：
    Recombinant Mouse ATP-binding cassette sub-family A member 1(Abca1) ,partial,Yeast
  • 貨號：
    CSB-YP001033MO1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse ATP-binding cassette sub-family A member 1(Abca1) ,partial,Yeast
  • 貨號：
    CSB-EP001033MO1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse ATP-binding cassette sub-family A member 1(Abca1) ,partial,Yeast
  • 貨號：
    CSB-EP001033MO1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse ATP-binding cassette sub-family A member 1(Abca1) ,partial,Yeast
  • 貨號：
    CSB-BP001033MO1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse ATP-binding cassette sub-family A member 1(Abca1) ,partial,Yeast
  • 貨號：
    CSB-MP001033MO1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Abca1
  • Uniprot No.：
  • 別名：
    Abca1; Abc1Phospholipid-transporting ATPase ABCA1; EC 7.6.2.1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 表達區(qū)域：
    1372 – 1656aa
  • 氨基酸序列
    GKYPSLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPDTPCLA GEEDWTISPVPQSIVDLFQNGNWTMKNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQ KTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNSQALPPSHEV NDAIKQMKKLLKLTKDSSADRFLSSLGRFMAGLDTKNNVKVWFNNKGWHAISSFLNVINN AILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apoliproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs.
  • 基因功能參考文獻：
    1. HSP70 promotes the progression of atherosclerosis in apoE-/- mice by suppressing the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway. PMID: 29678642
    2. It was concluded that quercetin inhibits oxLDLinduced lipid droplets in RAW264.7 cells by upregulation of ABCAl, ABCG1, LXRalpha and downregulation of PCSK9, p53, p21 and p16. PMID: 29845234
    3. these results suggest that apigenin may attenuate atherogenesis through up-regulating ABCA1-mediated cholesterol efflux and inhibiting inflammation. PMID: 29975943
    4. TMP upregulated the protein stability of ABCA1 without affecting ABCG1. Accordingly, TMP regulated the expression of SR-A, CD36, ABCA1 and ABCG1 in aortas of ApoE-/- mice, which resembled the findings observed in macrophages. PMID: 28791414
    5. HDL3, by interacting with ABCA1, modulates the miR143/145-myocardin axis and prevents the cholesterol-induced gene expression modification in smooth muscle cells regardless of its cholesterol unloading capacity. PMID: 28946038
    6. (1) ABCA1 maintains optimal hepatocyte PM FC, through intracellular FC trafficking, for efficient insulin signaling; and (2) hepatocyte ABCA1 deletion produces a form of selective insulin resistance so that lipogenesis is suppressed but glucose metabolism remains normal PMID: 28591582
    7. demonstrates behavior deficits caused by Abca1 deletion in APP/PS1DeltaE9 mouse model at an early stage of amyloid pathology. The basal deficits of Abca1ko, manifested by diminished cognitive performance, prevent them from coping with additional stressors, which is in part due to the impairment of neurite morphology in the hippocampus. PMID: 28106559
    8. Rutaecarpine was identified to be a candidate that protected ApoE(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 and SR-BI within RCT. PMID: 24908654
    9. Abca1 has a protective role in atherosclerosis, it exerts detrimental effects on cardiac function after myocardial infarction PMID: 27323229
    10. Caveolin-1 enhances internalization and degradation of ABCA1 by its association with ABCA1 PMID: 27579791
    11. ABCA1-derived nascent high-density lipoprotein-apolipoprotein AI and lipids metabolically segregate. PMID: 29074589
    12. an important role for hepatic ABCA1 in regulating secretory trafficking and modulating VLDL expansion during the TG accretion phase of hepatic lipoprotein particle assembly PMID: 28694219
    13. These studies showed that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway. PMID: 28642575
    14. PCSK9 plays a direct role on Abca1-mediated cholesterol efflux through a downregulation of Abca1 gene and Abca1 protein expression. This extrahepatic effect may influence relevant steps in the pathogenesis of atherosclerosis, such as foam cell formation. PMID: 27940374
    15. apoA-I/ABCA1-mediated cholesterol efflux without STAT3 activation can reduce proinflammatory cytokine expression in macrophages. PMID: 26989082
    16. Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR-ABCA1/ABCG1 cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL-C levels observed in patients receiving both medications PMID: 27251372
    17. The findings obtained from apoE-/- mice provide epigenetic insights into how EZH2 increases the risk of atherosclerotic heart disease. One of the pathways by which EZH2 leads to lipid accumulation and foam cell formation is via epigenetic downregulation of ABCA1 expression. PMID: 27295295
    18. Overexpressed NHE1 suppresses the expression of ABCA1 protein via increasing the calpain activity in RAW264.7 cells. PMID: 28031107
    19. Endothelial cholesterol efflux pathways mediated by ABCA1 and ABCG1 are nonredundant and atheroprotective, reflecting preservation of endothelial NO synthase activity and suppression of endothelial inflammation, especially in regions of disturbed arterial blood flow. PMID: 27199450
    20. ABCA1 mediates ApoA-I and ApoA-I mimetic peptide mobilization of extracellular cholesterol microdomains deposited by macrophages. PMID: 27758769
    21. ARF6-dependent pathway is the predominant route responsible for the ABCA1 internalization and degradation, whereas ARF6-independent endocytic pathways may contribute to ABCA1 recycling and efflux of intracellular cholesterol. PMID: 27758770
    22. EEPD1 is a novel LXR-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1. PMID: 28082258
    23. Pim-1L protects hepatic ABCA1 from lysosomal degradation by facilitating the physical interaction between ABCA1 and liver X receptor beta and subsequent stabilization of the ABCA1-Pim-1L complex and thereby regulates the circulating level of high-density lipoprotein. PMID: 27765770
    24. Nucleolin protects macrophages from oxLDL-induced foam cell formation in hyperlipidemia through up-regulating ABCA1 expression. PMID: 28315324
    25. This study suggests that enhancement of macrophage cholesterol metabolism by PPARgammais not contributed by activating ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI, which is not involved by CD36 expression either. PMID: 27890613
    26. exendin-4 increases ABCA1 expression in glomerular endothelial cells, which plays an important role in alleviating renal lipid accumulation, inflammation, and proteinuria in mice with type 2 diabetes. PMID: 27784780
    27. miR-33 augments macrophage lipid rafts and enhances proinflammatory cytokine induction and NF-kappaB activation by LPS. This occurs through an ABCA1- and ABCG1-dependent mechanism and is reversible by interventions upon raft cholesterol and by ABC transporter-inducing liver X receptor agonists. PMID: 27471270
    28. Thyrotropin upregulated hepatic ABCA1 to promote the efflux of intercellular cumulative cholesterol, resulting in increased plasma cholesterol. PMID: 27179782
    29. The ABCA1 may serve as an important feedback mechanism to modulate the magnitude of subsequent phagocytotic process of SCs in response to testicular injury. PMID: 26494466
    30. Absence of ABCA1 and low HDL level induce reduction of platelet reactivity by decreasing positive feedback loops, particularly TXA2 production through a hematopoietic ABCA1-independent mechanism. PMID: 26749169
    31. Both depletion of PARP-1 and inhibition of PARP-1 activity augmented LXR ligand-induced ABCA1 expression in the RAW 264.7 macrophage line and primary bone marrow-derived macrophages but did not affect LXR-dependent expression of other target genes, ABCG1 and SREBP-1c. PMID: 27026705
    32. Visfatin upregulated CD36 and SRA expression and downregulated ABCA1 and ABCG1 expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK-dependent pathways. PMID: 26536203
    33. These studies point to an important role for hematopoietic ABCA1 in modulating a feed-forward mechanism in obesity such that inflamed tissue macrophages stimulate the production of more monocytes, leading to an exacerbation of inflammation and associated disease processes. PMID: 26531812
    34. These findings may be clinically relevant because HDL's APOE content associates with CVD risk and ABCA1 deficiency promotes unregulated cholesterol accumulation in human macrophages. PMID: 26673204
    35. Short-term modulation of miR-27b expression in wild-type mice regulates hepatic LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels. PMID: 26520906
    36. LXR activation reduces the growth of xenograft tumour of human oral squamous cell carcinoma cells in mice accompanied by the upregulation of ABCA1 expression and the decline of cholesterol levels in the tumour. PMID: 26452260
    37. PGG enhances expression of SR-BI and ABCA1 in J774 and THP-1 macrophages PMID: 26322417
    38. ABCA1(-/-) macrophages deposited much less extracellular cholesterol than wild-type macrophages. These findings demonstrate a novel function of ABCA1 in contributing to macrophage export of cholesterol into the extracellular matrix. PMID: 26203076
    39. Our data suggest that GLP-1-based therapy modulate ABCA1/ABCG1 expression in adipocytes potentially through an LXR-alpha mediated process. PMID: 26603933
    40. The authors identify the putative lipid transporter Abca1 as a critical mediator of LXR's anti-inflammatory effects. PMID: 26173179
    41. SLP-2 is an ABCA1-dependent regulator of raft composition and of the innate immune response. PMID: 25910759
    42. identifies ABCA1 as a key macromolecule facilitating bidirectional sterol movement at the PM and shows that ABCA1 controls retrograde sterol transport by modulating a certain clathrin-independent endocytic process PMID: 26198636
    43. Diosgenin enhances ABCA1-dependent cholesterol efflux and inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression. PMID: 25765596
    44. Akt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1. PMID: 25415591
    45. HDL enhances transendothelial cholesterol transport by activation of a mechanism involving ABCA1, ABCG1 and SR-B1 but not involving PI3K and Akt. PMID: 26255968
    46. identified a plasma membrane-initiated signaling pathway that drives a rapid upregulation of ABCA1 mRNA and protein in the apoptotic cell clearance process linked to macrophage ABCA1 expression PMID: 26075824
    47. Suggest alpha/beta2-syntrophins do not regulate ABCA1 activity and insulin release but may have a role in regulating glucose uptake, ERK and SR-BI levels, and sphingomyelin metabolism in obesity. PMID: 25625330
    48. paeonol retarded the progress of atherosclerosis in ApoE(/) mice and modulated the expression of CD36 and ABCA1 in aortas similarly to that observed in macrophages PMID: 25405950
    49. the importance of ABCA1 in the prevention of cardiovascular and metabolic diseases PMID: 24992457
    50. NCOA5 is recruited to the Abca1 promoter, where it functions as an LXR corepressor.NCOA5 inhibits Abca1 gene expression by disrupting RNA Polymerase II recruitment and function. PMID: 25755249

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Endosome.
  • 蛋白家族：
    ABC transporter superfamily, ABCA family
  • 組織特異性：
    Widely expressed in adult tissues. Highest levels are found in pregnant uterus and uterus.
  • 數(shù)據(jù)庫鏈接：