FZD10 Antibody
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中文名稱:FZD10兔多克隆抗體
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貨號:CSB-PA006791
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規(guī)格:¥880
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:
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別名:FZD10; Frizzled-10; Fz-10; hFz10; FzE7; CD antigen CD350
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宿主:Rabbit
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反應種屬:Human,Mouse,Monkey
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免疫原:Synthesized peptide derived from the Internal region of Human Frizzled-10.
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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抗體亞型:IgG
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純化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式:Liquid
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應用范圍:WB, IHC, IF, ELISA
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相關(guān)產(chǎn)品
靶點詳情
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功能:Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
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基因功能參考文獻:
- there was a strong inverse correlation between nuclear immunostaining scores for beta-catenin expression and expression patterns of FZD10 PMID: 19134005
- FZD10 transactivation causes the activation of the Dvl-Rac1-JNK pathway and is associated with the development/progression of synovial sarcomas PMID: 19137009
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亞細胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:G-protein coupled receptor Fz/Smo family
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組織特異性:Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe an
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