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中文名稱:
FZD10兔多克隆抗體
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貨號(hào):
CSB-PA005299
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規(guī)格:
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圖片:
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:
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別名:
FZD10; Frizzled-10; Fz-10; hFz10; FzE7; CD antigen CD350
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宿主:
Rabbit
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反應(yīng)種屬:
Human,Mouse
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免疫原:
Synthesized peptide derived from the N-terminal region of Human Frizzled-10.
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免疫原種屬:
Homo sapiens (Human)
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標(biāo)記方式:
Non-conjugated
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抗體亞型:
IgG
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純化方式:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度:
It differs from different batches. Please contact us to confirm it.
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保存緩沖液:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式:
Liquid
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應(yīng)用范圍:
WB, ELISA
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推薦稀釋比:
Application |
Recommended Dilution |
WB |
1:500-1:2000 |
ELISA |
1:20000 |
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Protocols:
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儲(chǔ)存條件:
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
靶點(diǎn)詳情
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功能:
Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
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基因功能參考文獻(xiàn):
- there was a strong inverse correlation between nuclear immunostaining scores for beta-catenin expression and expression patterns of FZD10 PMID: 19134005
- FZD10 transactivation causes the activation of the Dvl-Rac1-JNK pathway and is associated with the development/progression of synovial sarcomas PMID: 19137009
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亞細(xì)胞定位:
Cell membrane; Multi-pass membrane protein.
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蛋白家族:
G-protein coupled receptor Fz/Smo family
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組織特異性:
Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe an
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數(shù)據(jù)庫(kù)鏈接:
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