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ZG16B

ZG16B是含有一個(gè)p-棱鏡結(jié)構(gòu)的哺乳動(dòng)物凝集素,這種結(jié)構(gòu)具有調(diào)控細(xì)胞黏附、轉(zhuǎn)移、凋亡、血管生成以及細(xì)胞與細(xì)胞間相互作用來識(shí)別病原體的能力。ZG16B位于人類染色體16p13.3基因位點(diǎn),為全長(zhǎng)721 bp cDNA的序列,并含有196個(gè)氨基酸的開放讀碼框區(qū),它的核酸結(jié)構(gòu)與人類唾液蛋白類似。ZG16B最早發(fā)現(xiàn)在胰腺癌中高表達(dá)并起重要致癌作用,進(jìn)而被鑒定為胰腺癌上調(diào)因子(PAUF,pancreaticadenocarcinoma upregulated factor)。在胰腺癌中,ZG16B通過激活CXCR4、β-catenin、TPL2/MEK/ERK、FAK/Scr等信號(hào)通路,促進(jìn)胰腺癌血管生成,調(diào)控胰腺癌細(xì)胞的遷移

更多ZG16B相關(guān)閱讀:ZG16B:一種新發(fā)現(xiàn)的癌基因,向胰腺癌發(fā)起挑戰(zhàn)!

熱銷產(chǎn)品

Recombinant Human Zymogen granule protein 16 homolog B(ZG16B) (Active)(CSB-MP836195HU)

驗(yàn)證數(shù)據(jù)

SDS-PAGE驗(yàn)證分子量大小及蛋白純度

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

功能性ELISA驗(yàn)證DDR1結(jié)合活性

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ZG16B at 2 μg/ml can bind Anti-ZG16B recombinant antibody (CSB-RA836195MA1HU), the EC50 is 24.13-46.04 ng/mL.

ZG16B Antibodies

ZG16B for Homo sapiens (Human)

ZG16B Proteins

ZG16B Proteins for Homo sapiens (Human)