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ZAP70

ZAP70,即ζ鏈相關(guān)激酶70,別名SRK、STD、TZK等。它來源于人類基因表達(dá),編碼一種屬于酪氨酸激酶家族的蛋白質(zhì)。ZAP70在T細(xì)胞和NK細(xì)胞中表達(dá),主要參與T細(xì)胞受體(TCR)的信號轉(zhuǎn)導(dǎo)途徑,通過其酪氨酸激酶活性激活T細(xì)胞和NK細(xì)胞的免疫活性。在生物學(xué)意義上,ZAP70的正常功能對于T細(xì)胞的正常發(fā)育和免疫應(yīng)答至關(guān)重要。此外,ZAP70的異常表達(dá)與某些疾病如慢性淋巴細(xì)胞白血病(CLL)的預(yù)后不良密切相關(guān),因此具有重要的臨床診斷和治療指導(dǎo)價值。

熱銷產(chǎn)品

Recombinant Human Tyrosine-protein kinase ZAP-70 (ZAP70) (CSB-EP026303HU)

驗證數(shù)據(jù)

CSB-EP026303HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ZAP70 Antibody (CSB-PA060103)

驗證數(shù)據(jù)

CSB-PA060103

Western Blot analysis of 293 cells using ZAP-70 Polyclonal Antibody

ZAP70 Antibodies

ZAP70 for Homo sapiens (Human)

ZAP70 for Mus musculus (Mouse)

ZAP70 Proteins

ZAP70 Proteins for Homo sapiens (Human)

ZAP70 Proteins for Mus musculus (Mouse)