VSIG4

VSIG4（V-set and immunoglobulin domain-containing 4，又稱為Complement receptor of the immunoglobulin superfamily，CRIg）是一種細(xì)胞表面蛋白，屬于免疫球蛋白超家族。它最初被發(fā)現(xiàn)是一種與補(bǔ)體系統(tǒng)相關(guān)的膜受體，在許多不同的細(xì)胞類型中都有表達(dá)，包括巨噬細(xì)胞、樹(shù)突狀細(xì)胞、中性粒細(xì)胞和肝細(xì)胞等，參與了多種生物學(xué)過(guò)程，包括免疫反應(yīng)、炎癥調(diào)節(jié)和腫瘤免疫治療等。作為一種膜受體，它可以與多種補(bǔ)體成分結(jié)合，包括C3b、iC3b和C1q等，從而調(diào)節(jié)免疫反應(yīng)的進(jìn)程。此外，VSIG4還可以作為一種調(diào)節(jié)炎癥反應(yīng)的受體，通過(guò)調(diào)節(jié)巨噬細(xì)胞的活化狀態(tài)來(lái)影響炎癥反應(yīng)的嚴(yán)重程度。

更多VSIG4相關(guān)閱讀：VSIG4：B7家族共刺激分子，補(bǔ)體系統(tǒng)或腫瘤藥開(kāi)發(fā)創(chuàng)新靶點(diǎn)！

熱銷產(chǎn)品

Recombinant Human V-set and immunoglobulin domain-containing protein 4(VSIG4),partial (Active)（CSB-MP896869HU）

驗(yàn)證數(shù)據(jù)

High Purity Validated by SDS-PAGE

The purity was greater than 95% as determined by SDS-PAGE. (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Immobilized Human VSIG4 at 2 μg/ml can bind Anti-VSIG4 recombinant antibody (CSB-RA896869MA1HU), the EC₅₀?is 51.14-68.73 ng/mL.