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SLC34A2

SLC34A2,即溶質(zhì)載體家族34成員A2,別名鈉-磷共運(yùn)輸?shù)鞍?”(NaPi2)/腎磷酸鹽重吸收蛋白等。SLC34A2是一種在細(xì)胞膜上表達(dá)的跨膜蛋白,屬于SLC34家族成員,主要在腎臟、小腸和某些腫瘤細(xì)胞中發(fā)揮作用。其作用機(jī)制涉及鈉依賴性磷酸鹽轉(zhuǎn)運(yùn),通過(guò)與鈉離子的協(xié)同運(yùn)輸,促進(jìn)磷酸鹽從尿液或腸腔重吸收到血液中。SLC34A2的活性受多種因素調(diào)節(jié),包括pH值、細(xì)胞外磷酸鹽和鈉離子濃度等,這種調(diào)節(jié)作用對(duì)維持體內(nèi)磷酸鹽平衡至關(guān)重要。SLC34A2在生物學(xué)上的意義主要體現(xiàn)在其對(duì)磷酸鹽穩(wěn)態(tài)的調(diào)控上。它參與了體內(nèi)磷酸鹽的吸收和重吸收過(guò)程,對(duì)骨骼健康、細(xì)胞信號(hào)傳導(dǎo)、能量代謝等具有重要影響。SLC34A2的功能異常與低磷血癥、佝僂病、骨軟化癥等磷酸鹽代謝紊亂疾病有關(guān)。此外,SLC34A2在腫瘤微環(huán)境中的表達(dá)可能與腫瘤的侵襲性和轉(zhuǎn)移能力有關(guān),因此,它也是癌癥研究和治療中的潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Sodium-dependent phosphate transport protein 2B (SLC34A2), partial (CSB-EP021581HU)

驗(yàn)證數(shù)據(jù)

CSB-EP021581HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SLC34A2 Antibody (CSB-PA140842)

驗(yàn)證數(shù)據(jù)

CSB-PA140842

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA140842(SLC34A2 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA140842

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA140842(SLC34A2 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)

SLC34A2 Antibodies

SLC34A2 for Homo sapiens (Human)

SLC34A2 Proteins

SLC34A2 Proteins for Homo sapiens (Human)

SLC34A2 Proteins for Bos taurus (Bovine)

SLC34A2 Proteins for Pongo abelii (Sumatran orangutan)

SLC34A2 Proteins for Rattus norvegicus (Rat)

SLC34A2 Proteins for Mus musculus (Mouse)