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ROR2

ROR2,即受體酪氨酸激酶樣孤兒受體2,別名ROR2、MFNG等。它是一種由ROR2基因編碼的跨膜蛋白,屬于ROR家族成員,在多種細(xì)胞類型中表達(dá)。ROR2的作用機(jī)制涉及與Wnt5A等配體結(jié)合,激活非經(jīng)典Wnt/PCP信號(hào)通路,參與調(diào)控細(xì)胞遷移、增殖和極性。ROR2的功能異常與某些疾病有關(guān),如骨骼發(fā)育異常、腫瘤發(fā)展等。ROR2在腫瘤細(xì)胞中的異常表達(dá)可能促進(jìn)腫瘤的侵襲和轉(zhuǎn)移,使其成為癌癥治療的潛在靶點(diǎn)。

熱銷產(chǎn)品

ROR2 Recombinant Monoclonal Antibody (CSB-RA932279MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA932279MA1HU

IHC image of CSB-RA932279MA1HU diluted at 1:100 and staining in paraffin-embedded human ovarian tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

ROR2 Antibodies

ROR2 for Homo sapiens (Human)