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PDGFRB

PDGFRB,即血小板衍生生長因子受體β,別名IBGC4、IMF1、JTK12、PDGF R beta、PDGFR 1。它是一種由PDGFRB基因編碼的跨膜受體酪氨酸激酶,主要在多種組織中表達,尤其在腎臟、肺和消化系統(tǒng)中。PDGFRB的作用機制主要是通過與其配體血小板衍生生長因子結(jié)合,激活下游的信號傳導(dǎo)途徑,如PI3K/AKT和RAS/RAF/MEK/ERK等,從而調(diào)控細胞的增殖、分化、遷移和存活。PDGFRB在生物學(xué)上的意義非常廣泛,它參與了多種生理過程的調(diào)節(jié),包括血管生成、器官發(fā)育和傷口愈合等。PDGFRB的功能異常與多種疾病有關(guān),如某些類型的癌癥和血管疾病,因此,它是藥物開發(fā)和疾病治療中的一個潛在靶點。

熱銷產(chǎn)品

Recombinant Human Platelet-derived growth factor receptor beta (PDGFRB), partial (CSB-EP017713HU)

驗證數(shù)據(jù)

CSB-EP017713HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PDGFRB Recombinant Monoclonal Antibody (CSB-RA213932A0HU)

驗證數(shù)據(jù)

CSB-RA213932A0HU

IHC image of CSB-RA213932A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

PDGFRB Antibodies

PDGFRB for Homo sapiens (Human)

PDGFRB Proteins

PDGFRB Proteins for Mus musculus (Mouse)

PDGFRB Proteins for Homo sapiens (Human)

PDGFRB Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

PDGFRB Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

PDGFRB ELISA Kit

PDGFRB ELISA Kit for Homo sapiens (Human)

PDGFRB ELISA Kit for Mus musculus (Mouse)