IL12B
IL12B，即白細(xì)胞介素12β鏈，是一種重要的細(xì)胞因子，由活化的巨噬細(xì)胞等炎性細(xì)胞產(chǎn)生。IL12B與IL12A基因編碼的35 kDα鏈通過二硫鍵連接形成異源二聚體，即具有生物活性的IL-12。其作用機(jī)制主要是通過與其受體IL-12R結(jié)合，激活JAK-STAT信號(hào)轉(zhuǎn)導(dǎo)通路，特別是通過JAK2/STAT4途徑，促進(jìn)Th1細(xì)胞的分化和活化，增強(qiáng)T細(xì)胞和NK細(xì)胞產(chǎn)生干擾素-γ(IFN-γ)的能力。IL12B在Th1型免疫應(yīng)答中發(fā)揮關(guān)鍵作用，促進(jìn)細(xì)胞介導(dǎo)的免疫反應(yīng)，對(duì)抗細(xì)胞內(nèi)病原體和腫瘤細(xì)胞。此外，IL12B的表達(dá)和活性還與多發(fā)性硬化等自身免疫疾病的發(fā)病機(jī)制有關(guān)。
熱銷產(chǎn)品
Recombinant Human Interleukin-12 subunit beta (IL12B) (CSB-YP011587HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL12B Recombinant Monoclonal Antibody (CSB-RA895985A0HU)
驗(yàn)證數(shù)據(jù)
Overlay Peak curve showing A549 cells stained with CSB-RA895985A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
IL12B Antibodies
IL12B for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011587GA01HU | IL12B Antibody | Human | ELISA,WB |
| CSB-PA06615A0Rb | IL12B Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA06615B0Rb | IL12B Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009590 | IL12B Antibody | Human | WB, ELISA |
| CSB-RA895985A0HU | IL12B Recombinant Monoclonal Antibody | Human | ELISA, FC |
IL12B for Sheep
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011587LA01SH | IL12B Antibody | Sheep | ELISA |
| CSB-PA011587YA01SH | IL12B Antibody | Sheep | ELISA, WB, IHC |
| CSB-PA011587LD01SH | IL12B Antibody, Biotin conjugated | Sheep | ELISA |
| CSB-PA011587YD01SH | IL12B Antibody, Biotin conjugated | Sheep | ELISA |
IL12B Proteins
IL12B Proteins for Capra hircus (Goat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011587GO CSB-EP011587GO CSB-BP011587GO CSB-MP011587GO CSB-EP011587GO-B |
Recombinant Goat Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011587SH | Recombinant Sheep Interleukin-12 subunit beta (IL12B) | Yeast |
| CSB-EP011587SH | Recombinant Sheep Interleukin-12 subunit beta (IL12B) | E.coli |
| CSB-BP011587SH CSB-MP011587SH CSB-EP011587SH-B |
Recombinant Sheep Interleukin-12 subunit beta (IL12B) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011587MO CSB-EP011587MO CSB-BP011587MO CSB-MP011587MO CSB-EP011587MO-B |
Recombinant Mouse Interleukin-12 subunit beta (Il12b) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP011587HU CSB-MP011587HU CSB-EP011587HU-B |
Recombinant Human Interleukin-12 subunit beta (IL12B) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011587HU | Recombinant Human Interleukin-12 subunit beta (IL12B) | E.coli |
| CSB-YP011587HU | Recombinant Human Interleukin-12 subunit beta (IL12B) | Yeast |
| CSB-EP011587HUc7 | Recombinant Human Interleukin-12 subunit beta (IL12B) | E.coli |
IL12B Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011587BO CSB-EP011587BO CSB-BP011587BO CSB-MP011587BO CSB-EP011587BO-B |
Recombinant Bovine Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011587MOW CSB-EP011587MOW CSB-BP011587MOW CSB-MP011587MOW CSB-EP011587MOW-B |
Recombinant Macaca mulatta Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011587CA CSB-EP011587CA CSB-BP011587CA CSB-MP011587CA CSB-EP011587CA-B |
Recombinant Cat Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011587DRI CSB-EP011587DRI CSB-BP011587DRI CSB-MP011587DRI CSB-EP011587DRI-B |
Recombinant Cercocebus atys Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Cervus elaphus (Red deer)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP631703DRN CSB-EP631703DRN CSB-BP631703DRN CSB-MP631703DRN CSB-EP631703DRN-B |
Recombinant Cervus elaphus Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP632962DO CSB-EP632962DO CSB-BP632962DO CSB-MP632962DO CSB-EP632962DO-B |
Recombinant Dog Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP637926PI CSB-EP637926PI CSB-BP637926PI CSB-MP637926PI CSB-EP637926PI-B |
Recombinant Pig Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Bubalus carabanensis (Swamp type water buffalo) (Bubalus bubalis carabanensis)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP652387BAAW CSB-EP652387BAAW CSB-BP652387BAAW CSB-MP652387BAAW CSB-EP652387BAAW-B |
Recombinant Bubalus carabanensis Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Marmota monax (Woodchuck)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP726757MQG CSB-EP726757MQG CSB-BP726757MQG CSB-MP726757MQG CSB-EP726757MQG-B |
Recombinant Marmota monax Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Bubalus bubalis (Domestic water buffalo)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP769698BWX CSB-EP769698BWX CSB-BP769698BWX CSB-MP769698BWX CSB-EP769698BWX-B |
Recombinant Bubalus bubalis Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Lama glama (Llama)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP771277LBS CSB-EP771277LBS CSB-BP771277LBS CSB-MP771277LBS CSB-EP771277LBS-B |
Recombinant Lama glama Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Papio anubis (Olive baboon)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP803041ERI CSB-EP803041ERI CSB-BP803041ERI CSB-MP803041ERI CSB-EP803041ERI-B |
Recombinant Papio anubis Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP817228MRG CSB-BP817228MRG CSB-MP817228MRG CSB-EP817228MRG-B |
Recombinant Mesocricetus auratus Interleukin-12 subunit beta (IL12B) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP846073GU CSB-EP846073GU CSB-BP846073GU CSB-MP846073GU CSB-EP846073GU-B |
Recombinant Cavia porcellus Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Sigmodon hispidus (Hispid cotton rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP856338SZK CSB-EP856338SZK CSB-BP856338SZK CSB-MP856338SZK CSB-EP856338SZK-B |
Recombinant Sigmodon hispidus Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP893607HO CSB-EP893607HO CSB-BP893607HO CSB-MP893607HO CSB-EP893607HO-B |
Recombinant Horse Interleukin-12 subunit beta (IL12B) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL12B ELISA Kit
IL12B ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04598h | Human Interleukin 12,IL-12/P40 ELISA KIT | serum, plasma, tissue homogenates | 0.039 ng/mL |
IL12B ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07360m | Mouse interleukin 12,IL-12/P40 ELISA KIT | serum, plasma, tissue homogenates | 3.9 pg/mL |
IL12B ELISA Kit for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11341p | Pig Interleukin 12,IL-12/P40 ELISA KIT | serum, plasma, cell culture supernates | 3.9 pg/mL |
IL12B ELISA Kit for Capra hircus (Goat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12103G | Goat interleukin 12,IL-12/P40 ELISA KIT | serum, plasma, tissue homogenates, cell lysates | 2.34 pg/mL |
