IGF2BP3

IGF2BP3，即胰島素樣生長(zhǎng)因子2的mRNA結(jié)合蛋白3，是一種RNA結(jié)合蛋白，其結(jié)構(gòu)包含RNA結(jié)合結(jié)構(gòu)域、RRM結(jié)構(gòu)域和蛋白質(zhì)互作結(jié)構(gòu)域。它通過(guò)與mRNA結(jié)合，促進(jìn)其穩(wěn)定性和翻譯過(guò)程，從而調(diào)控細(xì)胞的增殖、分化和存活。在生物學(xué)過(guò)程中，IGF2BP3扮演著重要角色，尤其在發(fā)育、腫瘤發(fā)生和干細(xì)胞形成等方面。作為N6-腺苷酸甲基化閱讀蛋白，它還能識(shí)別m6A GC序列，影響下游靶基因mRNA的穩(wěn)定性和翻譯。關(guān)于其信號(hào)通路，IGF2BP3可能通過(guò)與特定分子或蛋白質(zhì)相互作用，形成復(fù)雜的信號(hào)網(wǎng)絡(luò)，如在結(jié)直腸癌中，它與METTL14合作，通過(guò)m6A依賴的方式促進(jìn)EGFR mRNA的穩(wěn)定性和翻譯，進(jìn)而激活EGFR通路。因此，深入研究IGF2BP3的信號(hào)通路和調(diào)控機(jī)制對(duì)于理解其生物學(xué)功能以及開(kāi)發(fā)新的治療策略具有重要意義。

熱銷產(chǎn)品

● Recombinant Human Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

驗(yàn)證數(shù)據(jù)

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

● IGF2BP3 Antibody

驗(yàn)證數(shù)據(jù)

SDS

Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, HEK293 whole cell lysate, Mouse brain tissue
All lanes: IGF2BP3 antibody at 2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 64, 22 kDa
Observed band size: 64, 50 kDa

IHC

Immunofluorescent analysis of MCF-7 cells using CSB-PA011092LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

IHC

Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA011092LA01HU at dilution of 1:100

IHC

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA011092LA01HU at dilution of 1:100

IGF2BP3 Antibody

IGF2BP3 Protein

IGF2BP3 ELISA Kit

IGF2BP3 Antibodies

IGF2BP3 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA011092GA01HU	IGF2BP3 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA745585	IGF2BP3 Antibody	Human,Mouse	ELISA,WB
CSB-PA011092LA01HU	IGF2BP3 Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA011092LB01HU	IGF2BP3 Antibody, HRP conjugated	Human	ELISA
CSB-PA011092LC01HU	IGF2BP3 Antibody, FITC conjugated	Human
CSB-PA011092LD01HU	IGF2BP3 Antibody, Biotin conjugated	Human	ELISA

IGF2BP3 Proteins

IGF2BP3 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP011092HU CSB-BP011092HU CSB-MP011092HU CSB-EP011092HU-B	Recombinant Human Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP011092HU	Recombinant Human Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)	E.coli