HSPA5

HSPA5，即熱休克蛋白家族A成員5”，別名BiP、GRP78。它是一種分子伴侶蛋白，主要在內(nèi)質(zhì)網(wǎng)中發(fā)揮作用，由人體細(xì)胞自身的基因編碼。HSPA5的作用機制涉及幫助蛋白質(zhì)的正確折疊、組裝和運輸。當(dāng)細(xì)胞受到各種應(yīng)激條件，如熱休克、氧化應(yīng)激或營養(yǎng)物質(zhì)缺乏時，HSPA5的表達(dá)會顯著增加，以應(yīng)對蛋白質(zhì)折疊錯誤和聚集的問題。HSPA5通過形成復(fù)合體與未折疊或錯誤折疊的蛋白質(zhì)結(jié)合，防止它們聚集，并促進(jìn)其正確折疊或重折疊。HSPA5在生物學(xué)上的意義主要體現(xiàn)在其對細(xì)胞應(yīng)激反應(yīng)的調(diào)控和蛋白質(zhì)穩(wěn)態(tài)的維持上。作為內(nèi)質(zhì)網(wǎng)應(yīng)激反應(yīng)的關(guān)鍵分子伴侶，HSPA5參與了未折疊蛋白反應(yīng)（UPR），在細(xì)胞適應(yīng)和生存中發(fā)揮重要作用。HSPA5還與多種細(xì)胞過程相關(guān)，包括細(xì)胞信號傳導(dǎo)、細(xì)胞周期控制、細(xì)胞凋亡以及免疫應(yīng)答。在腫瘤細(xì)胞中，HSPA5的高表達(dá)與腫瘤細(xì)胞的增殖、侵襲和化療抗性有關(guān)，使其成為癌癥治療中的潛在靶點。此外，HSPA5在神經(jīng)退行性疾病中也有重要作用，其功能異?？赡芘c疾病的發(fā)生發(fā)展相關(guān)。

熱銷產(chǎn)品

Recombinant Human Endoplasmic reticulum chaperone BiP (HSPA5), partial (CSB-EP010827HU1)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

HSPA5 Recombinant Monoclonal Antibody (CSB-RA847116A0HU)

驗證數(shù)據(jù)

IHC image of CSB-RA847116A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.