HMGB1
HMGB1（High Mobility Group Box 1）是一種高遷移性群蛋白，屬于染色質(zhì)結(jié)構(gòu)蛋白家族。它在細(xì)胞核內(nèi)以特定的方式與DNA結(jié)合，幫助調(diào)節(jié)基因表達(dá)。HMGB1分子通常由兩個(gè)DNA結(jié)合域（A盒和B盒）以及一個(gè)非特異性連結(jié)區(qū)域（C盒）組成。HMGB1在細(xì)胞生物學(xué)中具有多種功能。在細(xì)胞核中，HMGB1可以結(jié)合DNA，調(diào)節(jié)基因轉(zhuǎn)錄和染色質(zhì)結(jié)構(gòu)，參與基因表達(dá)調(diào)控。在細(xì)胞質(zhì)中，HMGB1在細(xì)胞應(yīng)激、炎癥和免疫反應(yīng)中發(fā)揮重要作用。當(dāng)細(xì)胞受到損傷或遭受感染時(shí)，HMGB1可以被釋放到胞外，與免疫細(xì)胞上的特定受體（如RAGE、TLR4等）結(jié)合，觸發(fā)免疫細(xì)胞的活化和炎癥反應(yīng)。HMGB1被認(rèn)為是一種重要的促炎因子，它可以引導(dǎo)免疫細(xì)胞的遷移和激活，增強(qiáng)炎癥反應(yīng)，從而參與免疫應(yīng)答和組織修復(fù)。HMGB1也與自噬過程有關(guān)，可能在自噬的調(diào)節(jié)和執(zhí)行中發(fā)揮作用。HMGB1的研究已經(jīng)在多個(gè)領(lǐng)域得到廣泛的關(guān)注，包括基因調(diào)控、炎癥生物學(xué)、免疫學(xué)和腫瘤學(xué)等。它的作用在疾病的發(fā)展和治療中具有重要意義。
熱銷產(chǎn)品
● HMGB1 Recombinant Monoclonal Antibody CSB-RA010553MA1HU
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA010553MA1HU diluted at 1:100 and staining in paraffin-embedded human salivary gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
Overlay Peak curve showing Hela cells stained with CSB-RA010553MA1HU (red line) at 1:50. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
HMGB1 Antibodies
HMGB1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA01604A0Rb | HMGB1 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA01604B0Rb | HMGB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA01604C0Rb | HMGB1 Antibody, FITC conjugated | Human | |
| CSB-PA01604D0Rb | HMGB1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA010553GA01HU | HMGB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA049959 | HMGB1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000149 | Acetyl-HMGB1 (K12) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA002937 | HMGB1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA005927 | HMGB1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA995991 | HMGB1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA225274 | HMGB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010553YA01HU | HMGB1 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA010553YB01HU | HMGB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA010553YC01HU | HMGB1 Antibody, FITC conjugated | Human | |
| CSB-PA010553YD01HU | HMGB1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA439052A0HU | HMGB1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-RA010553MA1HU | HMGB1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF, FC |
HMGB1 for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010553NA01RA | Hmgb1 Antibody | Rat | ELISA, WB |
| CSB-PA010553NB01RA | Hmgb1 Antibody, HRP conjugated | Rat | ELISA |
| CSB-PA010553NC01RA | Hmgb1 Antibody, FITC conjugated | Rat | |
| CSB-PA010553ND01RA | Hmgb1 Antibody, Biotin conjugated | Rat | ELISA |
| CSB-PA010553NA01MO | Hmgb1 Antibody | Rat | ELISA, WB |
HMGB1 Proteins
HMGB1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP010553BO CSB-EP010553BO CSB-BP010553BO CSB-MP010553BO CSB-EP010553BO-B |
Recombinant Bovine High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP010553PI CSB-BP010553PI CSB-MP010553PI CSB-EP010553PI-B |
Recombinant Pig High mobility group protein B1 (HMGB1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-BP010553MO CSB-MP010553MO CSB-EP010553MO-B |
Recombinant Mouse High mobility group protein B1 (Hmgb1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP010553MO | Recombinant Mouse High mobility group protein B1 (Hmgb1) | E.coli |
| CSB-YP010553MO | Recombinant Mouse High mobility group protein B1 (Hmgb1) | Yeast |
HMGB1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP010553RA | Recombinant Rat High mobility group protein B1 (Hmgb1) | Yeast |
| CSB-EP010553RA | Recombinant Rat High mobility group protein B1 (Hmgb1) | E.coli |
| CSB-BP010553RA CSB-MP010553RA CSB-EP010553RA-B |
Recombinant Rat High mobility group protein B1 (Hmgb1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP010553RAa1 | Recombinant Rat High mobility group protein B1 (Hmgb1) | Yeast |
HMGB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP010553HU | Recombinant Human High mobility group protein B1 (HMGB1), partial | Yeast |
| CSB-RP016044h | Recombinant Human High mobility group protein B1 (HMGB1), partial | E.coli |
| CSB-EP010553HU CSB-BP010553HU CSB-EP010553HU-B |
Recombinant Human High mobility group protein B1 (Hmgb1), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP010553MO1 | Recombinant Mouse High mobility group protein B1 (HMGB1), partial | E.coli |
| CSB-MP010553HU | Recombinant Human High mobility group protein B1 (HMGB1) | Mammalian cell |
HMGB1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP362058DXU CSB-EP362058DXU CSB-BP362058DXU CSB-MP362058DXU CSB-EP362058DXU-B |
Recombinant Cricetulus griseus High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Papio anubis (Olive baboon)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP434996ERI CSB-EP434996ERI CSB-BP434996ERI CSB-MP434996ERI CSB-EP434996ERI-B |
Recombinant Papio anubis High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP523735DOA CSB-EP523735DOA CSB-BP523735DOA CSB-MP523735DOA CSB-EP523735DOA-B |
Recombinant Arabidopsis thaliana High mobility group B protein 1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Callithrix jacchus (White-tufted-ear marmoset)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP533334CYL CSB-EP533334CYL CSB-BP533334CYL CSB-MP533334CYL CSB-EP533334CYL-B |
Recombinant Callithrix jacchus High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Callicebus moloch (Dusky titi monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP541463CYE CSB-EP541463CYE CSB-BP541463CYE CSB-MP541463CYE CSB-EP541463CYE-B |
Recombinant Callicebus moloch High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP600961HO CSB-EP600961HO CSB-BP600961HO CSB-MP600961HO CSB-EP600961HO-B |
Recombinant Horse High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP703137MOV CSB-EP703137MOV CSB-BP703137MOV CSB-MP703137MOV CSB-EP703137MOV-B |
Recombinant Macaca fascicularis High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP751094DO CSB-EP751094DO CSB-BP751094DO CSB-MP751094DO CSB-EP751094DO-B |
Recombinant Dog High mobility group protein B1 (HMGB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HMGB1 ELISA Kit
HMGB1 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL010553DO | Dog High mobility group protein B1(HMGB1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
HMGB1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08223h | Human High mobility group protein B1,HMGB-1 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 19.5 pg/mL |
HMGB1 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08225m | Mouse High mobility group protein B1,HMGB-1 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
HMGB1 ELISA Kit for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL010553PI | Pig High mobility group protein B1(HMGB1) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
HMGB1 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08224r | Rat High mobility group protein B1,HMGB-1 ELISA Kit | serum, plasma, tissue homogenates |
