GRM2

GRM2，即代謝型谷氨酸受體2，別名GPRC1B、mGlu2、MGLUR2等。它是一種G蛋白偶聯(lián)受體(GPCR)，主要在神經(jīng)元和肌肉細(xì)胞上表達(dá)。GRM2的作用機(jī)制是通過與特定的配體結(jié)合，激活細(xì)胞內(nèi)的信號轉(zhuǎn)導(dǎo)通路，影響細(xì)胞內(nèi)的生理過程。配體結(jié)合導(dǎo)致GRM2發(fā)生構(gòu)象變化，進(jìn)而觸發(fā)通過鳥苷酸結(jié)合蛋白（G蛋白）的信號傳導(dǎo)，并調(diào)節(jié)下游效應(yīng)因子，如腺苷酸環(huán)化酶的活性。GRM2的信號傳導(dǎo)抑制了腺苷酸環(huán)化酶活性，可能參與調(diào)節(jié)神經(jīng)傳導(dǎo)的抑制或與突觸形成及突觸穩(wěn)定有關(guān)。GRM2在生物學(xué)上的意義非常重要，它不僅在神經(jīng)系統(tǒng)中發(fā)揮關(guān)鍵作用，調(diào)節(jié)突觸傳遞和海馬功能，還涉及到多種神經(jīng)病理狀態(tài)，包括神經(jīng)退行性疾病和精神疾病。GRM2的表達(dá)在成年海馬齒狀顆粒細(xì)胞中特別高，對成年海馬中新生齒狀顆粒細(xì)胞的發(fā)育和功能整合至關(guān)重要。此外，GRM2還通過調(diào)節(jié)MEK/ERK1/2信號通路的磷酸化和激活狀態(tài)，影響神經(jīng)元的發(fā)育。GRM2的功能異常與多種腦部疾病的發(fā)生發(fā)展有關(guān)，因此，它也是藥物開發(fā)和神經(jīng)科學(xué)研究的重要靶點(diǎn)。

熱銷產(chǎn)品

GRM2 Antibody (CSB-PA621775LA01HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: Rat heart tissue
All lanes: GRM2 antibody at 5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 96 kDa
Observed band size: 96 kDa

Immunofluorescence staining of HepG2 cells with CSB-PA621775LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).