FADD

FAS相關(guān)死亡區(qū)結(jié)構(gòu)域蛋白是由FADD基因編碼的人類蛋白質(zhì)。它作為一種凋亡適配分子，將半胱氨酸蛋白酶8或半胱氨酸蛋白酶10招募到活化的Fas（CD95）或TNFR-1受體上。形成的復(fù)合物稱為死亡誘導(dǎo)信號復(fù)合物（DISC），并對半胱氨酸蛋白酶8進(jìn)行蛋白酶活化?；钚园腚装彼岬鞍酌?啟動介導(dǎo)細(xì)胞凋亡的下一級半胱氨酸蛋白酶級聯(lián)反應(yīng)。該蛋白質(zhì)參與干擾素介導(dǎo)的抗病毒免疫應(yīng)答，在干擾素信號轉(zhuǎn)導(dǎo)的正向調(diào)控中發(fā)揮作用。
FAS-associated death domain protein is a protein in humans that is encoded by FADD gene. Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.