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DSG2

DSG2(Desmoglein-2),是一種細(xì)胞粘附蛋白,屬于鈣黏蛋白家族的一員。主要在上皮細(xì)胞中表達(dá),如皮膚、心臟、肺、腸道等組織。DSG2的結(jié)構(gòu)特點包括外部區(qū)域和細(xì)胞膜跨膜區(qū)。外部區(qū)域包含多個結(jié)構(gòu)域,其中包括多個鈣離子結(jié)合位點,這些結(jié)構(gòu)域有助于DSG2與其他細(xì)胞間連接蛋白(如其他DSG蛋白或Plakophilin)相互作用,形成一種稱為"橋粒"(desmosomes)的連接結(jié)構(gòu)。 這種"橋粒"連接可以使上皮細(xì)胞緊密連接在一起,增強組織的結(jié)構(gòu)穩(wěn)定性,并提供細(xì)胞間的強大黏附力。這對于維持組織的完整性和穩(wěn)定性至關(guān)重要,尤其是在受到外部力量時,如心臟的搏動、皮膚的拉伸等情況下,它可以使上皮組織具有強大的耐受力。DSG2的功能異??赡軐?dǎo)致一些疾病。例如,某些遺傳性皮膚疾病和心臟病與DSG2的突變或異常表達(dá)有關(guān)。

更多相關(guān)閱讀:DSG2:橋粒芯蛋白家族DSGs表達(dá)最廣泛的成員,心肌病、腺病毒和腫瘤新興靶點?

熱銷產(chǎn)品

DSG2 Recombinant Monoclonal Antibody CSB-RA622752MA1HU

驗證數(shù)據(jù)

ELISA
CSB-RA004952MA1HU ELISA

The Binding Activity of DSG2 with anti-DSG2 antibody

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DSG2 (CSB-MP622752HU) at 2 μg/mL can bind Anti-DSG2 recombinant antibody,the EC50 is 20.26-38.00 ng/mL

Recombinant Human Desmoglein-2(DSG2),partial (Active) CSB-MP622752HU

驗證數(shù)據(jù)

SDS
CSB-MP622752HU SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
CSB-MP622752HU ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DSG2 at 2μg/mL can bind Anti-DSG2 recombinant antibody (CSB-RA622752MA1HU), the EC50 is 20.26-38.00 ng/mL

DSG2 Antibodies

DSG2 for Homo sapiens (Human)

DSG2 Proteins

DSG2 Proteins for Mus musculus (Mouse)

DSG2 Proteins for Homo sapiens (Human)