DLG4
DLG4，即盤狀大型蛋白4，別名Postsynaptic density protein 95;PSD-95、Synapse-associated protein 90、SAP-90、SAP90。它是一種在大腦中高度表達的蛋白，由人體細胞自身的基因編碼。DLG4的作用機制主要是作為突觸后密度(PSD)的組成部分，通過其PDZ結構域、SH3結構域和鳥苷酸激酶樣結構域(GKLD)，與多種蛋白質相互作用，如NMDA受體亞基和鉀通道，參與調控突觸的成熟、形態(tài)和功能。DLG4在突觸形成和突觸可塑性中發(fā)揮關鍵作用，影響學習和記憶過程。DLG4的異常表達或功能失調與多種神經系統(tǒng)疾病有關，包括智力障礙、自閉癥、注意力缺陷多動障礙(ADHD)和癲癇等。DLG4的突變或異常剪接可能導致神經發(fā)育障礙，如DLG4相關的突觸病變，表現(xiàn)為早期發(fā)病的全面發(fā)育遲緩、智力障礙、自閉癥譜系障礙和ADHD等。
熱銷產品
Recombinant Human Disks large homolog 4 (DLG4) (CSB-EP006938HU)
驗證數(shù)據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DLG4 Recombinant Monoclonal Antibody (CSB-RA255792A0HU)
驗證數(shù)據
Western Blot
Positive WB detected in: Rat Brain whole cell lysate, Mouse Brain whole cell lysate
All lanes: PSD95 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 81, 86, 81 kDa
Observed band size: 95 kDa
DLG4 Antibodies
DLG4 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA007805 | DLG4 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA284504 | DLG4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA575557 | DLG4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA006938LA01HU | DLG4 Antibody | Human | ELISA, IHC |
| CSB-PA006938LB01HU | DLG4 Antibody,HRP conjugated | Human | ELISA |
| CSB-PA006938LC01HU | DLG4 Antibody，F(xiàn)ITC conjugated | Human | |
| CSB-RA255792A0HU | DLG4 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB |
DLG4 Proteins
DLG4 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006938HU CSB-BP006938HU CSB-EP006938HU-B |
Recombinant Human Disks large homolog 4 (DLG4) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP006938HU | Recombinant Human Disks large homolog 4 (DLG4) | E.coli |
| CSB-MP006938HU | Recombinant Human Disks large homolog 4 (DLG4) | Mammalian cell |
DLG4 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006938RA CSB-BP006938RA CSB-MP006938RA CSB-EP006938RA-B |
Recombinant Rat Disks large homolog 4 (Dlg4) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DLG4 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP730775MO CSB-EP730775MO CSB-BP730775MO CSB-MP730775MO CSB-EP730775MO-B |
Recombinant Mouse Disks large homolog 4 (Dlg4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DLG4 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP744171DIL CSB-EP744171DIL CSB-BP744171DIL CSB-MP744171DIL CSB-EP744171DIL-B |
Recombinant Danio rerio Disks large homolog 4 (dlg4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
