CXCL12
CXCL12，即趨化因子配體12，別名Thymic lymphoma cell-stimulating factor、Tlsf、TLSF-a、TLSF-b、Tlsfa、Tlsfb、TPAR1。它是一種在多種生理和病理過程中發(fā)揮重要作用的小分子細(xì)胞因子，由多種細(xì)胞類型分泌，尤其在胚胎發(fā)育、造血、血管生成和炎癥等過程中。CXCL12的作用機(jī)制主要是通過與其高親和力受體CXCR4結(jié)合，激活下游信號傳導(dǎo)途徑，如通過Gαi蛋白激活PI3K/AKT和ERK/MAPK等信號通路，從而影響細(xì)胞的增殖、遷移和存活。CXCL12不僅參與了細(xì)胞的趨化作用，還與腫瘤的發(fā)生、發(fā)展和預(yù)后密切相關(guān)。在腫瘤中，CXCL12/CXCR4信號通路通過促進(jìn)腫瘤細(xì)胞的增殖、運動、黏附、侵襲、轉(zhuǎn)移和分泌等，影響腫瘤的發(fā)展。此外，CXCL12/CXCR4信號通路還在缺血性腦卒中中發(fā)揮作用，通過動員內(nèi)皮祖細(xì)胞參與修復(fù)血管內(nèi)皮和神經(jīng)損傷，促進(jìn)腦功能恢復(fù)以及改善生存質(zhì)量。因此，CXCL12是細(xì)胞生物學(xué)和疾病研究中的一個重要分子靶點。
熱銷產(chǎn)品
CXCL12 Antibody (CSB-PA004056)
驗證數(shù)據(jù)
Western Blot analysis of HepG2 cells using SDF-1 Polyclonal Antibody
Western Blot analysis of KB HELA MCF-7 cells using SDF-1 Polyclonal Antibody
Human stromal cell-derived factor 1 alpha (SDF1A) ELISA kit (CSB-EQ027490HU)
驗證數(shù)據(jù)
貨號：CSB-EQ027490HU
規(guī)格：96T/48T
靈敏度：7.81 pg/mL
檢測范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CXCL12 Antibodies
CXCL12 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004056 | CXCL12 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA968386 | CXCL12 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA185715 | CXCL12 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA711650 | CXCL12 Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA343703LA01HU | CXCL12 Antibody | Human | ELISA, IHC |
| CSB-PA343703LB01HU | CXCL12 Antibody,HRP conjugated | Human | ELISA |
| CSB-PA343703LC01HU | CXCL12 Antibody，F(xiàn)ITC conjugated | Human | |
| CSB-PA343703LD01HU | CXCL12 Antibody，Biotin conjugated | Human | ELISA |
CXCL12 Proteins
CXCL12 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006242MO CSB-EP006242MO CSB-BP006242MO CSB-MP006242MO CSB-EP006242MO-B |
Recombinant Mouse Stromal cell-derived factor 1 (Cxcl12) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006242MO1 | Recombinant Mouse Stromal cell-derived factor 1 (Cxcl12), partial | E.coli |
| CSB-AP001161MO | Recombinant Mouse Stromal cell-derived factor 1 protein (Cxcl12), partial (Active) | E.Coli |
| CSB-AP001171MO | Recombinant Mouse Stromal cell-derived factor 1 protein (Cxcl12) | E.Coli |
CXCL12 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP343703HU CSB-EP343703HU CSB-BP343703HU CSB-MP343703HU CSB-EP343703HU-B |
Recombinant Human Stromal cell-derived factor 1 (CXCL12) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP000741HU | Recombinant Human Stromal cell-derived factor 1 protein (CXCL12) (Active) | E.Coli |
| CSB-AP000751HU | Recombinant Human Stromal cell-derived factor 1 protein (CXCL12) | E.Coli |
| CSB-AP000761HU | Recombinant Human Stromal cell-derived factor 1 (CXCL12), partial (Active) | E.Coli |
CXCL12 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP527681CA CSB-EP527681CA CSB-BP527681CA CSB-MP527681CA CSB-EP527681CA-B |
Recombinant Cat Stromal cell-derived factor 1 (CXCL12) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCL12 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP685743XBF CSB-EP685743XBF CSB-BP685743XBF CSB-MP685743XBF CSB-EP685743XBF-B |
Recombinant Xenopus tropicalis Stromal cell-derived factor 1 (cxcl12) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCL12 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP844964XBE CSB-EP844964XBE CSB-BP844964XBE CSB-MP844964XBE CSB-EP844964XBE-B |
Recombinant Xenopus laevis Stromal cell-derived factor 1 (cxcl12) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCL12 ELISA Kit
CXCL12 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04722h | Human stromal cell derived factor 1β(SDF-1β/SDF1B) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 31.25 pg/mL |
| CSB-EQ027490HU | Human stromal cell-derived factor 1 alpha (SDF1A) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 7.81 pg/mL |
CXCL12 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04723m | Mouse Stromal cell derived factor 1β,SDF-1β ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 7.81 pg/mL |
| CSB-EQ027494MO | Mouse stromal cell derived factor 1α(SDF-1α/SDF1A)ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.039 ng/mL |
